Vestibular signal integration in hippocampal place cells

海马位置细胞的前庭信号整合

• 批准号: 9316952
• 负责人: J David Dickman
• 金额: $ 22.16万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9316952
• 关键词: Affect; Alzheimer' s Disease; Animals; Area; Cell physiology; Cells; Characteristics; Cognition; Cognitive; Communities; Computer Simulation; Conflict (Psychology); Coupled; Cues; Dementia; Development; Environment; Episodic memory; Frequencies; Generations; Goals; Head; Hippocampus (Brain); Human; Laboratories; Light; Link; Location; Locomotion; Maintenance; Maps; Medial; Medicine; Motion; Motor; Mus; Neurosciences; Nobel Prize; Organ; Pattern; Physiology; Process; Property; Proprioception; Reporting; Research; Rodent; Role; Rotation; Semicircular canal structure; Sensory; Signal Transduction; Slave; Speed; System; Testing; Theta Rhythm; Visual; Visual Motion; Work; brain cell; cell type; cognitive function; design; entorhinal cortex; experience; experimental study; hexapod; indexing; insight; multimodality; multisensory; neural circuit; optic flow; otoconia; place fields; platform-independent; relating to nervous system; response; virtual; virtual reality; visual optics; visual stimulus; visual-vestibular; way finding

PROJECT SUMMARY/ABSTRACT Previous studies in rodents have identified five major cell types that are involved in navigation functions, including head direction (HD), place, grid, border cells, and speed cells. Hippocampal Place (HP) cells are reported to encode the spatial location of the animal during active exploration. However, recent studies using head or body fixed virtual reality environments have reported a reduction in HP spatial tuning and a loss of theta rhythm. We hypothesize that these effects upon HP cell function derive from a conflict between visual- locomotor cues and a lack of appropriate vestibular cues to signal active motion. The current project is designed to directly test the type of vestibular motion information used by HP cells to form and maintain spatial location information. Both real world and virtual reality environments will be used while examining HP cell function using a unique virtual reality system we have built that is mounted onto a rotatory motor embedded in a 6DOF hexapod. Specific Aim 1 will determine if HP cells spatial tuning requires vestibular motion signals congruent to visual-locomotion cues by delivering rotational and linear motion profiles that are slaved to the animal's locomotion in the virtual environment. Specific Aim 2 will determine how vestibular rotational and linear motion signals separately affect HP cell function. We hypothesize that vestibular rotational signals are necessary for HP cell spatial tuning and vestibular linear motion cues are necessary for theta rhythm amplitude and frequency. The project represents a new area of research for our laboratory, thus it is appropriate for an exploratory/development R21 application. Our long-term goal is to understand the how vestibular mechanisms contribute to spatial navigation.

项目概要/摘要 先前对啮齿动物的研究已经确定了参与导航功能的五种主要细胞类型， 包括头部方向 (HD)、位置、网格、边界单元和速度单元。海马区 (HP) 细胞是 据报道在主动探索过程中对动物的空间位置进行编码。然而，最近的研究使用 头部或身体固定虚拟现实环境报告 HP 空间调整减少，并且损失 西塔节奏。我们假设这些对 HP 细胞功能的影响源于视觉- 运动线索和缺乏适当的前庭线索来发出主动运动信号。目前的项目是 旨在直接测试 HP 细胞用于形成和维持空间的前庭运动信息类型 位置信息。检查 HP 电池时将使用现实世界和虚拟现实环境 使用我们构建的独特虚拟现实系统的功能，该系统安装在嵌入的旋转电机上 6DOF 六足机构。具体目标 1 将确定 HP 细胞空间调谐是否需要前庭运动信号 通过提供从属于视觉运动线索的旋转和线性运动轮廓来一致 动物在虚拟环境中的运动。具体目标 2 将确定前庭旋转和 线性运动信号分别影响 HP 细胞功能。我们假设前庭旋转信号是 HP 细胞空间调谐所必需，前庭线性运动线索对于 theta 节律振幅是必需的 和频率。该项目代表了我们实验室的一个新的研究领域，因此适合 探索/开发 R21 应用程序。我们的长期目标是了解前庭机制如何 为空间导航做出贡献。