RISK FACTORS FOR AIDS AMONG IV DRUG USERS

静脉注射毒品使用者患艾滋病的危险因素

• 批准号: 6604007
• 负责人: DON C DES JARLAIS
• 金额: $ 81.62万
• 依托单位: BETH ISRAEL MEDICAL CTR (NEW YORK)
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-10 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6604007
• 关键词: AIDS; AIDS /HIV test; HIV infections; behavioral /social science research tag; clinical research; communicable disease control; communicable disease transmission; disease /disorder proneness /risk; gender difference; geographic site; health surveys; hepatitis; high risk behavior /lifestyle; human data; human subject; hypodermic needle; interview; intravenous drug abuse; longitudinal human study; questionnaires; racial /ethnic difference; relapse /recurrence; serology /serodiagnosis; socioenvironment; urban area

With over 50,000 cases of AIDS and 100,000 cases of HIV infection, the HIV epidemic among injecting drug users (IDUs) in New York City is by far the largest local HIV epidemic among IDUs in the world. Recently, we have observed important positive developments in this epidemic, including: continuing reductions in risk behavior, declining HIV seroprevalence, and low HIV incidence. Whether these positive trends continue will have very important implications for the study of large, high seroprevalence HIV epidemics, which account for the majority of new HIV infections in the U.S. and in industrialized countries. The specific aims for this competing, continuation proposal are to study: 1. Long-term trends in HIV seroprevalence among IDUs in New York City, possible differences in seroprevalence trends in different demographic subgroups, and to monitor estimated HIV incidence. 2. Long-term trends in HIV risk behavior among IDUs in New York City, and characteristics of persons who continue or relapse to high risk behavior. 3. Social network and "mixing" patterns among IDUs, and how these relate to HIV infection and risk reduction. 4. Transitions between non-injecting and injecting drug use, and characteristics of new injectors, including risk behavior, social networks, and HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) infection. 5. Audio- computer assisted self interviewing as a method for obtaining more complete reporting of HIV risk behaviors. These aims will be accomplished through continuation of cross- sectional surveys of 1000 persons per year entering Beth Israel Medical Center drug treatment programs in New York City. These surveys will include an extensive questionnaire and HIV, HBV, and HCV testing. A random assignment comparison of audio-computer interviewing versus face-to-face interviewing will be embedded in the first 15 months of data collection. The proposed research will provide information of great scientific interest and public health importance regarding the dynamics of high seroprevalence HIV epidemics, the ability of IDUs to sustain risk reduction over long time periods, transitions between non-injecting and injecting drug use, and methods for improving collection of HIV risk behavior data.

在纽约市注射吸毒者（IDU）中，艾滋病毒的流行中有超过50,000例艾滋病和100,000例艾滋病毒感染，是迄今为止IDU中最大的局部艾滋病毒流行。 最近，我们观察到这一流行病的重要积极发展，包括：持续减少风险行为，HIV血清阳性下降和HIV发病率低。 这些积极的趋势是否继续将对大型，高清血清的艾滋病毒流行病的研究具有非常重要的影响，这解释了美国和工业化国家的大多数新艾滋病毒感染。这项竞争，持续建议的具体目的是研究：1。纽约市IDU之间的HIV血清阳性率的长期趋势，不同人群亚组的血清阳性趋势可能差异，并监测估计的HIV艾滋病毒发病率。 2。纽约市IDU的艾滋病毒风险行为的长期趋势，以及继续或复发到高风险行为的人的特征。 3. IDU之间的社交网络和“混合”模式，以及这些模式与HIV感染和降低风险之间的关系。 4。非注射和注射药物使用之间的过渡，以及新注射器的特征，包括风险行为，社交网络和HIV，乙型肝炎病毒（HBV）（HBV）和丙型肝炎病毒（HCV）感染。 5。音频计算机协助自我访谈是一种获得更完整的艾滋病毒风险行为报告的方法。这些目标将通过对纽约市贝丝以色列医疗中心药物治疗计划的每年1000人进行横断面调查来实现。 这些调查将包括广泛的问卷和HIV，HBV和HCV测试。 音频计算机采访与面对面访谈的随机分配比较将嵌入到数据收集的前15个月中。拟议中的研究将提供有关高血清阳性艾滋病毒流行病的动态的极大科学兴趣和公共健康重要性的信息，IDU在长期内维持降低风险的能力，未注射和注射药物使用之间的过渡以及改善HIV风险行为收集的方法。