Biomarkers of Blood Brain Barrier Injury in Methamphetamine Use and HIV Disease

甲基苯丙胺使用和艾滋病毒疾病中血脑屏障损伤的生物标志物

基本信息

批准号：
9249011
负责人：
Jennifer E Iudicello
金额：
$ 20.52万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-01 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9249011
关键词：
Acquired Immunodeficiency Syndrome Affect Area Basement membrane Biological Biological Markers Blood Blood - brain barrier anatomy Brain Cell Adhesion Molecules Clinical Clinical Research Collaborations Communicable Diseases Data Collection Development Diagnosis Disease Endothelial Cells Fostering Foundations Functional disorder Future Goals Grant HIV Health Immune system Individual Influentials Injury Investigation Knowledge Laboratories Lead Link Measures Mediating Membrane Proteins Mentored Patient-Oriented Research Career Development Award Mentors Methamphetamine Methamphetamine dependence Monitor Nervous System Trauma Neurobiology Neurocognitive Neurocognitive Deficit Neuronal Injury Neuropsychology Neurosciences Outcome Pathogenesis Pathogenicity Persons Prevalence Process Proteins Public Health Reporting Research Research Infrastructure Research Methodology Research Personnel Resources Risk Factors Role Science Serum Albumin Services Stem cells Structure Substance abuse problem Tight Junctions Training Universities Vascular Diseases Vascular System Virus Work addiction analytical method antiretroviral therapy assay development base biomarker panel career central nervous system injury drug development effective therapy experience experimental study functional decline functional disability functional outcomes immune activation improved innovation insight methamphetamine effect methamphetamine use multidisciplinary neuroAIDS neurobehavioral neurovascular neurovascular injury outcome forecast patient oriented patient oriented research programs public health relevance skills specific biomarkers statistics tool translational research program

项目摘要

The purpose of Dr. Jennifer Iudicello’s K23 application is to provide focused training and mentoring in the neurobiological aspects of methamphetamine (METH) addiction and HIV disease that builds on her strong academic foundation in the neurocognitive and functional consequences of addictions and neuroAIDS in service of her long-term goals as an independent, transdisciplinary patient-oriented investigator. The proposed training, knowledge, and research experience will promote her development into an independent investigator capable of bridging laboratory neurobiological discoveries with their clinical expression and real-world impact among persons living with METH addiction and HIV disease. This work is of considerable

Jennifer Iudicello 博士的 K23 应用程序的目的是提供以下领域的集中培训和指导：甲基苯丙胺 (METH) 成瘾和艾滋病毒疾病的神经生物学方面的研究建立在她强大的基础上成瘾和神经艾滋病的神经认知和功能后果的学术基础作为一名独立的、跨学科的、以患者为中心的研究者，她致力于实现她的长期目标。培训、知识和研究经验将促进她发展成为一名独立研究者能够将实验室神经生物学发现与其临床表达和现实世界影响联系起来这项工作意义重大。