Enhanced MR for morphological characterization of ligaments, tendons and bone

增强 MR 用于韧带、肌腱和骨骼的形态表征

基本信息

批准号：
10709528
负责人：
Xiaojuan Li
金额：
--
依托单位：
STATE UNIVERSITY OF NEW YORK AT BUFFALO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-05 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10709528
关键词：
Acceleration Address Anatomy Awareness Base Sequence Biomedical Engineering Biomedical Research Body part Cartilage Diseases Clinical Collagen Computer software Connective Tissue Connective Tissue Diseases Dedications Development Diabetes Mellitus Diagnosis Disease Disease Management Evaluation Frequencies Hand Human Image Imaging Device Imaging Techniques Injury Interdisciplinary Study Involuntary Movements Joints Knee Ligaments Limb structure Lower Extremity Magnetic Resonance Imaging Magnetism Methods Minnesota Morphologic artifacts Morphology Motion Musculoskeletal Musculoskeletal Diseases Musculoskeletal System Natural graphite Osteoporosis Outcome Pennsylvania Performance Periosteum Persons Physicians Predisposition Printing Public Health Relaxation Reproducibility Research Resolution Rheumatism Safety Scanning Scientist Shapes Signal Transduction Solid Specimen Speed Structure System Techniques Technology Tendon structure Testing Theoretical model Time Tissues United States Universities Upper Extremity Visualization absorption bone bone imaging calcification clinical diagnosis clinically relevant cortical bone design design and construction design verification diagnostic tool diagnostic value disability flexibility foot high resolution imaging human subject human tissue imaging modality imaging scientist improved in vivo ligament injury millisecond musculoskeletal imaging non-invasive imaging novel safety assessment solid state substantia spongiosa technology validation tissue injury tool transmission process ultra high resolution

项目摘要

PROJECT SUMMARY/ABSTRACT According to Council for Disability Awareness, diseases of the musculoskeletal system and connective tissue, such as the ligaments, tendons and bone are the #1 cause of disability in the United States. MR imaging has been increasingly becoming the diagnostic tool of choice for evaluation and management of these diseases and injuries due to its potential of providing information on not only anatomic structure but also function noninvasively. However, the capability of MRI in studying human ligaments, tendons and bone is limited by inadequate sensitivity and slow acquisitions of conventional MR technology. Semi-solid/solid tissues, including collagen-rich tissues such as calcified ligaments and tendons, as well as periosteum, cortical bone and trabecular bone, provide very little MR signal with traditional MRI due to their very short transverse (T2) relaxation time of a few milliseconds or less. In addition, during the long acquisition times, involuntary movements of human subjects introduce motion artifacts, posing a critical challenge in obtaining high- resolution images with diagnostic value. Several recently developed technologies have the potential to address these limitations. Ultrahigh field 7T MRI, parallel imaging, and compressed sensing have demonstrated unique advantages of high sensitivity and fast acquisitions in vivo. Studies on musculoskeletal imaging using ultra- short echo time (UTE) and zero echo time (ZTE) methods have shown unparalleled capability to image short T2 species normally invisible in MRI. However, the implementation of these technologies at ultrahigh fields is challenging due to design difficulties of the required high frequency multichannel coil arrays, as well as the problems associated with ultrahigh fields, e.g. increased susceptibility, B1 inhomogeneity, and increased SAR. In this study, through a synergistic bioengineering research partnership, we propose a comprehensive project for developing advanced hardware and imaging methods at 7T to enable morphological and functional characterization of human ligaments, tendons and bone. These developments aim to produce highly sensitive, isotropic ~100-150um resolution images of semi-solid connective tissues with clinically relevant contrast in 1 minute scan time. Hardware developments will include multichannel coil arrays for knee and extremities using quadrature and flexible array technology with metamaterial decoupling, as well as application of pyrolytic graphite materials for reducing susceptibility artifacts. Imaging acquisition developments will be based on improved UTE/ZTE sequences, and we propose new integrated techniques for improved semi-solid tissue contrast, motion correction, and acceleration using parallel imaging and compressed sensing. We will also validate the methods developed and assess the performance and safety/SAR. This research would provide sensitive imaging tools for morphological and functional characterization of ligaments, tendons and bone, which are highly demanded and essential for studying semi-solid connective tissues. We expect this research will have a long-term clinical impact in the management of musculoskeletal system diseases and injuries.

项目摘要/摘要根据残疾意识委员会的说法，肌肉骨骼系统和结缔组织的疾病，例如韧带，肌腱和骨骼是美国残疾的第一名。成像先生有越来越成为评估和管理这些疾病的诊断工具由于其潜力不仅提供有关解剖结构的信息，而且还起作用无创的。但是，MRI在研究人韧带，肌腱和骨骼中的能力受到限制传统MR技术的灵敏度不足和慢速获取。半固体/固体组织，包括富含胶原蛋白的组织，例如钙化的韧带和肌腱，以及骨膜，皮质骨和小梁骨，由于其非常短的横向（T2），很少有传统MRI信号提供的MR信号很少（T2）放松的时间几毫秒或更少。此外，在漫长的收购时期，非自愿人类受试者的运动引入了运动伪像，在获得高位的方面构成了关键的挑战具有诊断值的分辨率图像。最近开发的技术有可能解决这些限制。 Ultrahigh Field 7T MRI，平行成像和压缩感知已显示出独特的在体内高灵敏度和快速获取的优势。研究使用超肌肉骨骼成像的研究短回波时间（UTE）和零回波时间（ZTE）方法显示出无与伦比的图像短 T2物种通常在MRI中不可见。但是，这些技术在超高领域的实施是由于所需的高频多通道线圈阵列的设计困难而挑战与超高领域相关的问题，例如易感性增加，B1不均匀性和SAR增加。在这项研究中，通过协同工程研究伙伴关系，我们提出了一个全面的项目用于开发7T的高级硬件和成像方法以实现形态和功能人韧带，肌腱和骨骼的表征。这些发展旨在产生高度敏感的各向同性〜100-150UM分辨率的半固体结缔组织图像，具有临床相关对比度为1 微小的扫描时间。硬件开发将包括使用多通道线圈阵列，用于膝盖和四肢正交和灵活的阵列技术，具有超材料的解耦，以及热解的应用用于降低易感性伪像的石墨材料。成像获取的发展将基于改进的UTE/ZTE序列，我们提出了新的集成技术，以改善半固体组织对比度，运动校正和使用并行成像和压缩感测。我们也会验证开发的方法并评估性能和安全/SAR。这项研究将提供韧带，肌腱和骨骼形态学和功能表征的敏感成像工具，这是高度要求，对于研究半固体结缔组织至关重要。我们期望这项研究将对肌肉骨骼系统疾病和伤害的管理产生长期临床影响。

项目成果

期刊论文数量（33）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A Dielectric Material Coated Half-Wave Dipole antenna for Ultrahigh Field MRI at 7T/300MHz.

DOI：
pii: 4103
发表时间：
2022-05
期刊：
Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition
影响因子：
0
作者：
通讯作者：

A Dedicated 36-Channel Receive Array for Fetal MRI at 3T.

用于 3T 胎儿 MRI 的专用 36 通道接收阵列

DOI：
10.1109/tmi.2018.2839191
发表时间：
2018-10
期刊：
IEEE transactions on medical imaging
影响因子：
10.6
作者：
Chen Q;Xie G;Luo C;Yang X;Zhu J;Lee J;Su S;Liang D;Zhang X;Liu X;Li Y;Zheng H
通讯作者：
Zheng H

Detection and tracking enhancement using 4-channels local standalone resonators for catheterized interventional MRI at 3T.

使用 4 通道局部独立谐振器进行 3T 导管介入 MRI 的检测和跟踪增强。