Johns Hopkins University Site Consortium - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)

约翰·霍普金斯大学站点联盟 - HIV/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心（UM2 临床试验可选）

• 批准号: 10709609
• 负责人: ALLISON L AGWU
• 金额: $ 31.32万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709609
• 关键词: AIDS clinical trial group; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent Medicine; Adolescent Medicine Trials Network; Adolescent and Young Adult; Adult; Advocate; Age; Age Years; Baltimore; Black race; Caring; Childhood; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Collaborations; Communicable Diseases; Communities; Community Networks; Continuity of Patient Care; Data Collection; Development; Disease Progression; Disparity; Drug Kinetics; Ensure; Equity; Failure; Funding; Goals; Government; HIV; HIV Infections; HIV diagnosis; HIV/AIDS; Hispanic; Home; Industry; Infrastructure; Institution; International; International Maternal Pediatric Adolescent AIDS Clinical Trials; Intervention; Intervention Studies; Investigational Drugs; Latinx; Lead; Maryland; Outcome; Outcomes Research; Persons; Policies; Policy Maker; Population; Prevention; Productivity; Public Health; Research; Research Activity; Research Infrastructure; Research Personnel; Risk; Science; Site; Social Behavior; State Government; Testing; Translational Research; Underrepresented Populations; United States; Universities; Vaccines; Viral; Voice; Youth; adolescent health outcomes; antiretroviral therapy; clinical care; cohort; community organizations; design; disease transmission; disorder risk; empowerment; epidemic preparedness; experience; improved; innovation; lens; marginalization; member; multidisciplinary; novel; operation; programs; protocol development; recruit; retention rate; success; synergism; virtual; young adult

ABSTRACT Johns Hopkins University Youth (ages 13-24) living with HIV comprise one fourth of new HIV diagnoses in the United States (U.S.) and have the lowest rates of engagement and retention in care and prevention, initiation of antiretroviral treatment, and virologic suppression, increasing the risk of disease progression and transmission, with important public health implications. These disparities threaten the U.S. government's target of ending new HIV infections by 2030, outlined in the Ending the Epidemic Plan for America (EHE). The Adolescent Trials' Network (ATN), the only youth-targeted HIV network, combines expertise in clinical care and research to develop optimal approaches to addressing the challenges facing youth at-risk for and living with HIV. Located in Baltimore, Maryland, an EHE jurisdiction, the Johns Hopkins Adolescent Young Adult Research Equity for Adolescent Care and HIV Consortium (JHU AYA REACH) has a long-standing overarching commitment to mitigate the impact of HIV and improve health outcomes for AYA at-risk and/or living with HIV via a clinical research program focused on integrated, cross-disciplinary studies of AYA-centered novel interventions (e.g., biomedical, management, strategy) that span from bedside to community. Synergies between clinical care research, public health, and community, centered on AYA, substantially enhances relevance, improves feasibility, optimizes success, and amplifies impact. The JHU AYA REACH infrastructure aims to optimize these synergies ultimately uniting the scientific rigor (clinical trial design and implementation, outcomes, interventions) with clinical expertise and real-world understanding, ensuring that research questions/answers are relevant, implementable, and scalable. Led by Drs. Agwu and Sanders (Co-Project Leads), the JHU AYA REACH, has a longstanding and productive involvement in clinical trials' networks and cohorts (ATN, International Maternal Pediatric Adolescent AIDS Clinical Trials' Group [IMPAACT]) with much of that involvement overseen by Westat and JHU AYA REACH is home to a prolific group of diverse, collaborative multidisciplinary investigators. The consortium includes an established network of community and governmental partners increasing the likelihood of effective translation of the research outcomes. For this application, we will: (1) Develop and conduct science that incorporates innovative approaches to addressing the critical scientific gaps and questions impacting AYAs, particularly Black and Hispanic/LatinX AYA, at-risk for or living with HIV; (2) Coordinate with diverse entities, affiliates, and stakeholders across the institution and community, including AYAs, to ensure timely, accurate, and effective engagement in the proposed research; and (3) En sure that AYA voices and lived experiences are central to the research activities of the JHU AYA REACH through active and purposeful involvement of AYA through the Youth Advisory Board (YAB) and other forums. The JHU AYA REACH's expertise, experience, and goals directly align with the ATN enriching the capacity to develop and conduct innovative and impactful interdisciplinary AYA-specific research, providing added overall value to the proposed ATN.

摘要约翰·霍普金斯大学 年轻人（13-24岁）患有艾滋病毒的年轻人包括美国（美国）和 在护理和预防方面的参与度和保留率最低，抗逆转录病毒治疗的启动， 和病毒学抑制，增加了疾病进展和传播的风险，重要的公众 健康影响。这些差异威胁到美国政府结束新的艾滋病毒感染的目标 2030年，在《美国流行计划》（EHE）结束时概述了。青少年试验网络（ATN）， 只有以青年为目标的艾滋病毒网络，结合了临床护理和研究方面的专业知识来发展最佳 应对年轻人面临的艾滋病毒和生活的青年面临的挑战的方法。位于巴尔的摩， 马里兰州，司法管辖区，约翰·霍普金斯（Johns Hopkins） 护理和艾滋病毒财团（Jhu aya Reach）有一项长期的总体承诺，以减轻 艾滋病毒的影响并改善AYA高风险和/或通过临床研究生活的健康结果 专注于以AYA为中心的新型干预措施的综合跨学科研究（例如， 生物医学，管理，策略），从床边到社区。临床护理之间的协同作用 以AYA为中心的研究，公共卫生和社区大大提高了相关性，可提高 可行性，优化成功并放大影响。 Jhu Aya涉及基础设施旨在优化 这些协同作用最终将科学严谨（临床试验设计和实施，结果， 干预措施）具有临床专业知识和现实世界的理解，确保研究/答案 是相关，可实现的，可扩展的。由博士领导。 Agwu和Sanders（共同项目引线），Jhu aya REACH，长期以来又有富有成效的参与参与临床试验的网络和队列（ATN， 国际孕产妇青少年艾滋病临床试验“ Incract [incract]） 由Westat和Jhu Aya Reach监督的参与是一群多样的合作的家园 多学科研究人员。该财团包括一个既定的社区网络， 政府合作伙伴增加了有效翻译研究结果的可能性。为了这 应用程序，我们将：（1）开发和进行科学，结合了针对解决的创新方法 影响AYA的关键科学差距和问题，尤其是黑人和西班牙裔/拉丁裔AYA 因为艾滋病毒或生活； （2）与整个机构的不同实体，分支机构和利益相关者协调 包括AYA在内的社区，以确保及时，准确，有效地参与拟议的研究； （3）en 当然，Aya的声音和生活经历对于Jhu Aya的研究活动至关重要 通过青年顾问委员会（Yab）和其他 论坛。 Jhu Aya触及的专业知识，经验和目标直接与ATN保持一致 开发和进行创新和有影响力的跨学科AYA特定研究的能力，提供 提出的ATN增加了总价值。