Michigan Center on Lifestage Environmental Exposures and Disease

密歇根生命阶段环境暴露和疾病中心

基本信息

批准号：
9058296
负责人：
Rita K Loch-Caruso
金额：
$ 150.25万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-15 至 2021-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9058296
关键词：
Address Adolescent Adult Affect Age Aging Bioinformatics Child Chronic Disease Clinical Communities Community Outreach Complex Core Facility Coupled Development Disease Disease Pathway Endocrine Environmental Exposure Environmental Health Epidemiology Fostering Foundations Funding Future Genomics Goals Grant Health Health Sciences Human Biology Infant Inflammation Knowledge Life Longevity Medical Metabolic Michigan Mission National Institute of Environmental Health Sciences Oxidative Stress Pilot Projects Predisposition Prevention Research Public Health Research Research Activity Research Personnel Research Support Research Training Resources Scientist Staging Strategic Planning Structure Superfund Training Translating Translations Universities career career development disorder prevention epigenomics human disease improved innovation middle age novel prenatal prevent programs public health intervention public health relevance reproductive

项目摘要

DESCRIPTION (provided by applicant) This is the first competing renewal application for the Environmental Health Sciences (EHS) Core Center at the University of Michigan, submitted in the final year of the initial four years of NIEHS support. The Center is organized around the theme of critical windows of susceptibility to environmental exposures as important determinants of disease, forming the Michigan Center of Lifestage Environmental Exposures and Disease (M- LEEaD). Lifestage, as used in this application, refers to clinically-recognized stages of development, mid-life, and aging that pertain to the preconception, prenatal, infant, child, adolescent, reproductive age adult, and aging adult periods of life. The Center builds on a strong foundation of research activity and support at the University of Michigan in this emergent arena of environmental public health, with 16 NIEHS grants moving into the next funding period that includes a Children's Environmental Health and Disease Prevention Research Center and participation in a Superfund Research Program Center. The mission of M-LEEaD is to accelerate research that defines impacts of environmental exposures during vulnerable stages of life, and to promote translation of these findings to improve medical and public health interventions for the mitigation of chronic disease. The Center implements its mission through infrastructural support of established and new investigators applying novel transdisciplinary approaches that increase understanding of mechanisms by which environmental exposures target vulnerable stages of life. Support for research is provided through integrated Center programs that include a Pilot Project Program, three Facility Cores, and three Research Teams to create synergy for stimulation of innovative research. The Facility Cores are: 1) Integrated Health Sciences Core (IHSC); 2) Exposure Assessment Core (EAC); and 3) Omics and Bioinformatics Core (OBIC). Research Teams are organized around key mechanistic pathways of disease: 1) Inflammation & Oxidative Stress; 2) Genomics & Epigenomics; and, 3) Endocrine & Metabolic Disruption. Research is coupled with the engagement of stakeholder communities through the Community Outreach and Engagement Core (COEC) and training of future leaders in EHS through the Center Career Development Program. The functioning of the Center is overseen by an Administrative Core. M-LEEaD strives to accomplish its mission through the following specific aims: 1) Integrate and build upon existing institutional programs and facilities to provide structure and resources that accelerate understanding of the complex relationships among environmental exposures, human biology, and disease; 2) Foster integration, coordination, and cooperation among investigators across traditional disciplinary boundaries to conduct high-quality research that translates to improved strategies towards preventing environmentally-induced disorders; 3) Build programmatic and scientific capacity through support for scientists at critical career stages, but especially those at early- and mid-career stages, to engage in research that addresses critical, emerging questions in environmental health; and, 4) Interact with affected communities in a bidirectional manner to identify community environmental health concerns and to translate research findings into community engagement opportunities.

描述（由申请人提供）这是密歇根大学环境健康科学 (EHS) 核心中心的第一份竞争性更新申请，于最初四年的最后一年提交。 NIEHS 支持。该中心围绕环境暴露的关键窗口这一疾病重要决定因素的主题进行组织，形成了密歇根生命阶段环境暴露和疾病中心 (M-LEEaD)。该中心建立在与孕前、产前、婴儿、儿童、青少年、育龄成人和老年阶段相关的临床公认的发育、中年和衰老阶段。密歇根大学在环境公共卫生这个新兴领域的研究活动和支持奠定了坚实的基础，16 项 NIEHS 赠款进入下一个资助期，其中包括儿童环境健康和疾病预防研究中心以及参与超级基金研究计划中心M-LEEaD 的使命是加速研究，确定生命脆弱阶段环境暴露的影响，并促进这些研究结果的转化，以改善医疗和公共卫生干预措施，以减轻慢性病。该中心通过基础设施履行其使命。支持现有和新的研究人员应用新颖的跨学科方法，增加对环境暴露针对生命脆弱阶段的机制的理解，通过综合中心计划提供研究支持，其中包括一个试点项目计划、三个设施核心和三个研究团队来创建。促进创新研究的协同作用包括：1) 综合健康科学核心 (IHSC)；2) 暴露评估核心 (EAC)；3) 组学和生物信息学核心 (OBIC)。研究团队围绕疾病的关键机制进行组织：1) 炎症和氧化应激；2) 基因组学和表观基因组学；3) 内分泌和代谢紊乱研究通过社区外展和参与核心与利益相关者社区的参与相结合。 COEC）并通过中心职业发展计划对未来的 EHS 领导者进行培训该中心的运作由 M-LEEaD 负责监督。努力通过以下具体目标来完成其使命： 1) 整合和发展现有的机构计划和设施，提供结构和资源，以加速对环境暴露、人类生物学和疾病之间复杂关系的理解 2) 促进整合、协调；以及跨越传统学科界限的研究人员之间的合作，开展高质量的研究，从而转化为预防环境引起的疾病的改进策略；3) 通过支持处于关键职业阶段的科学家，特别是早期和早期阶段的科学家，建立规划和科学能力；职业生涯中期，到参与解决环境健康中关键的、新出现的问题的研究；以及，4) 以双向方式与受影响的社区互动，以确定社区环境健康问题并将研究结果转化为社区参与机会。