Translational Research in Alzheimer's Disease and related Dementias (TRADD)

阿尔茨海默病和相关痴呆症的转化研究 (TRADD)

• 批准号: 10709167
• 负责人: ROBERTA EILEEN BRINTON
• 金额: $ 29.45万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709167
• 关键词: Alzheimer' s disease related dementia; Translational Research

Project Summary/Abstract The University of Arizona (UArizona) Training Program to Advance Translational Research on Alzheimer's Disease and AD Related Dementias (AZ-TRADD) is designed to address knowledge and experience gaps in AD therapeutic discovery and preclinical translational development. To meet this challenge, the UArizona Translational Research in AD and related Dementias (AZ-TRADD) training program is designed as a problem based translational learning experience for predoctoral Ph.D and M.D./Ph.D fellows. In alignment with the 2021 NIH Alzheimer’s Research Summit: Path to Precision Medicine for Treatment and Prevention and the 2011 National Alzheimer’s Project Act (NAPA), the goal of the AZ-TRADD training program is to fill critical gaps that exist for AD translational research in academic graduate programs. To achieve this goal, the AZ-TRADD program will: 1) recruit trainees across multiple scientific disciplines; 2) employ problem-based learning approaches to solve challenges in AD therapeutic development with emerging tools and techniques; and 3) equip AZ-TRADD trainees with career development and leadership skills necessary to conduct team science and manage multidisciplinary teams. Through this approach, we ensure that AZ-TRADD trainees develop deep translational research expertise necessary for AD therapeutic development, while: 1) cultivating the ability to creatively and collaboratively solve problems working with experts across the translational landscape as part of large-scale team science; 2) gaining an applied understanding of how data science, particularly using data generated by AMP-AD, M2OVE-AD and ADNI, can accelerate translational research and provide avenues to novel therapeutic insights; 3) connecting geno- and phenotypic variations and multifaceted etiology of AD to therapeutic targets; and 4) gaining essential professional and business skills to navigate a diverse funding landscape and translate discoveries into the clinical setting. AZ-TRADD fellows will receive career mentoring and leadership development skills to manage multi-disciplinary teams in the 21st century that is Patient Inspired and Data Driven. The AZ- TRADD training program will develop a diverse, cross-disciplinary, and translationally oriented workforce to meet the critical challenge of creating a workforce capable of advancing therapeutics to prevent, delay, and treat AD and AD related dementias.

项目摘要/摘要 亚利桑那大学（Uarizona）培训计划，以推进有关阿尔茨海默氏症的翻译研究 疾病和与AD相关的痴呆症（AZ-Tradd）旨在解决广告中的知识和经验差距 治疗发现和临床前翻译发展。为了应对这一挑战，乌里佐纳纳 AD和相关痴呆症（AZ-TRADD）培训计划的转化研究被设计为一个问题 基于博士学位和M.D./ph.d研究员的基于翻译学习经验。与2021年保持一致 NIH阿尔茨海默氏症的研究峰会：治疗和预防精确医学的途径和2011年 国家阿尔茨海默氏症的项目法案（NAPA），AZ-Tradd培训计划的目标是填补关键的空白 存在于学术研究生课程中的广告翻译研究。为了实现这一目标，AZ-Tradd计划 威尔：1）跨多个科学学科的招募受训者； 2）员工基于问题的学习方法 通过新兴工具和技术解决广告热开发方面的挑战； 3）装备AZ-Tradd 具有职业发展和领导能力的学员可以进行团队科学和管理 多学科团队。通过这种方法，我们确保AZ-TRADD学员发展深厚的翻译 广告疗法开发所需的研究专业知识，而：1）培养创造性和 作为大规模的一部分，协作解决与翻译景观专家合作的问题 团队科学； 2）对数据科学的应用，特别是使用由数据科学产生的数据 AMP-AD，M2OVE-AD和ADNI可以加速翻译研究，并为新疗法提供途径 见解； 3）将AD的Geno和表型变化以及多方面的病因连接到治疗靶标； 4）获得必不可少的专业和业务技能来导航不同的基础景观并翻译 发现进入临床环境。 AZ-Tradd研究员将获得职业心理和领导力发展 在21世纪，受患者启发和数据驱动的21世纪多学科团队的技能。 AZ- TRADD培训计划将开发潜水员，跨学科和面向翻译的劳动力，以满足 创建能够推进治疗以预防，延迟和治疗广告的劳动力的关键挑战 和与AD相关的痴呆症。