Neural Damage in Methamphetamine Users: An MRS Study

甲基苯丙胺使用者的神经损伤：一项 MRS 研究

• 批准号: 6717712
• 负责人: THOMAS EDWARD NORDAHL
• 金额: $ 22.28万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6717712
• 关键词: attention; behavior test; behavioral /social science research tag; bioimaging /biomedical imaging; chronic brain damage; cingulate gyrus; clinical research; cognition; dopamine receptor; drug abuse; drug interactions; human middle age (35-64); human subject; memory; methamphetamine; neuroimaging; neuropsychological tests; neurotoxicology; nuclear magnetic resonance spectroscopy; patient oriented research; prefrontal lobe /cortex; serotonin receptor; young adult human (21-34)

High dose exposure of animals to methamphetamine [MA] causes significant damage to frontostriatal brain regions, which are relatively rich in dopaminergic [DA] and serotonergic [5-HT] innervation. Although animal models of drug addiction are extremely valuable, convergent findings from human studies are critical if one is to understand the impact of long-term MA use on the human brain. The goal of this proposal is to examine the effects of long-term effects of MA use in frontostriatal regions using proton magnetic resonance spectroscopy [MRS] in conjunction with mature neurons (primarily N- acetyl aspartase [NAA], high energy metabolic products (phosphocreatine and creatine [Cr], cell membrane synthesis or degradation (choline [Cho]), and glia (myoInositol [mI). MRS is a safe non-invasive tool that can detect certain proton spectroscopic metabolite patterns associated with brain damage and has been validated as a viable tool in detecting neuronal damage in both animals and humans. The interdisciplinary approach of MRS and cognitive assessment will yield valuable data essential for understanding the cognitive sequelae of neuronal damage resulting from MA abuse. Our preliminary data from methamphetamine dependent (MD) subjects (n=9) reveal likely neuronal damage in the prefrontal cortex [PFC] and anterior cingulate [ACC] as well as deficits on attentional tasks subserved by these regions. The proposed work is essential to confirm these clinically important findings by testing a larger sample of MD subjects and controls, using MRS in conjunction with sensitive computerized tasks of attention and memory. NAA, Choline, myo- Inositol and creatine will be measured in the PFC (dorsal and ventral), ACC, striatum, and control structures (primary visual cortex). Group differences in levels of NAA, Chol, mI, and Cr in the above regions will be determined by repeated measured analysis of variance. A similar analysis approach will be applied to the behavioral data. Correlational analyses between cognitive measures and imaging data from specific hypothesized regions of interest will be conducted.

动物的高剂量暴露于甲基苯丙胺[MA]对额叶脑区域造成了重大损害，这些脑部脑区域的多巴胺能[DA]和血清素能[5-HT]神经支配相对较丰富。尽管药物成瘾​​的动物模型非常有价值，但如果要了解长期MA使用对人脑的影响，人类研究的收敛发现至关重要。 The goal of this proposal is to examine the effects of long-term effects of MA use in frontostriatal regions using proton magnetic resonance spectroscopy [MRS] in conjunction with mature neurons (primarily N- acetyl aspartase [NAA], high energy metabolic products (phosphocreatine and creatine [Cr], cell membrane synthesis or degradation (choline [Cho]), and glia （MRS是一个安全的非侵入性工具，可以检测到与脑损伤相关的某些质子的非侵入型工具，并作为一种可行的工具来验证MRS和认知评估的互动，以检测两种动物的神经元损害来自甲基苯丙胺依赖性（MD）受试者（n = 9）的初步数据显示，前额叶皮层[PFC]和前扣带回[ACC]可能神经元损伤，以及这些地区对注意力任务的缺陷。提出的工作对于通过使用MRS结合使用敏感的注意力和记忆任务来测试较大的MD受试者和对照样本来确认这些临床上重要的发现至关重要。 NaA，胆碱，肌肌醇和肌酸将在PFC（背侧和腹侧），ACC，纹状体和控制结构（主要视觉皮层）中进行测量。上述区域中NAA，CHOL，MI和CR水平的群体差异将通过重复测量的方差分析来确定。类似的分析方法将应用于行为数据。将进行来自特定假设的感兴趣区域的认知度量和成像数据之间的相关分析。

项目成果

Spatial inhibition and the visual cortex: a magnetic resonance spectroscopy imaging study.

• DOI: 10.1016/j.neuropsychologia.2011.01.014
• 发表时间: 2011-04
• 期刊: Neuropsychologia
• 影响因子: 2.6
• 作者: Salo R;Nordahl TE;Buonocore MH;Natsuaki YT;Moore CD;Waters C;Leamon MH
• 通讯作者: Leamon MH

Findings of preserved implicit attention in methamphetamine dependent subjects.

甲基苯丙胺依赖受试者保留内隐注意力的发现。

• DOI: 10.1016/j.pnpbp.2007.08.012
• 发表时间: 2008
• 期刊: Progress in neuro-psychopharmacology & biological psychiatry
• 影响因子: 5.6
• 作者: Salo,Ruth;Leamon,MartinH;Natsuaki,Yutaka;Moore,Charles;Waters,Christy;Nordahl,ThomasE
• 通讯作者: Nordahl,ThomasE

Preliminary evidence of behavioral predictors of recurrent drug-induced psychosis in methamphetamine abuse.

甲基苯丙胺滥用中复发性药物诱发精神病的行为预测因素的初步证据。

• DOI: 10.1016/j.psychres.2007.04.018
• 发表时间: 2008
• 期刊: Psychiatry research
• 影响因子: 11.3
• 作者: Salo,Ruth;Nordahl,ThomasE;Leamon,MartinH;Natsuaki,Yutaka;Moore,CharlesD;Waters,Christy;Carter,CameronS
• 通讯作者: Carter,CameronS