2017 The Cell Biology of Megakaryocytes & Platelets Gordon Research Conference & Gordon Research Seminar

2017 巨核细胞的细胞生物学

• 批准号: 9248106
• 负责人: Wolfgang Bergmeier
• 金额: $ 1.87万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9248106
• 关键词: Academia; Address; Affect; Apoptosis; Area; Biology; Blood Cells; Blood Platelet Disorders; Blood Platelets; Blood coagulation; Cardiovascular Diseases; Cells; Cellular biology; Clinical; Coffee; Collaborations; Coupled; Data; Development; Diagnosis; Disease; Fostering; Future; Genetic; Genomic approach; Goals; Gray unit of radiation dose; Growth; Hematological Disease; Hemorrhage; Hemostatic function; Immunity; Infection; Inflammation; International; Knowledge; Lesion; Link; Longevity; Lymphatic; Malignant Neoplasms; Mediating; Mediator of activation protein; Medical Genetics; Medicine; Megakaryocytes; Mentors; Mission; Mutation; Myeloproliferative disease; Myocardial Infarction; Nature; Neoplasm Metastasis; Outcome; Pathologic; Play; Prevention; Process; Production; Publications; Recording of previous events; Regulation; Research; Research Personnel; Role; STK6 gene; Seminal; Stem Cell Development; Stem cells; Stroke; Syndrome; Technology; Therapeutic; Thrombosis; Thrombus; Time; Ursidae Family; Work; Wound Healing; career; cell type; design; exome sequencing; experience; genome wide association study; genomic biomarker; improved; inhibitor/antagonist; leukemia; meetings; novel; novel therapeutics; professor; programs; receptor; symposium; therapeutic target; tumor

PROJECT SUMMARY / ABSTRACT The biennial Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on the Cell Biology of Megakaryocytes and Platelets brings together current leaders, junior investigators and trainees working on the development and disorders of the megakaryocyte lineage. It is the premier international meeting in the field. The ongoing, long-term scientific mission is to bridge the gap between researchers working on different aspects of the lineage, i.e. stem cells, megakaryocytes and platelets. This mission is more relevant than ever, as the interdependence between each cell type becomes increasingly clear, e.g. the role of megakaryocytes in stem cell development, and the impact of inflammation on megakaryocyte growth and platelet production. The overarching, aim of the GRC is to allow current and emerging leaders of the field to communicate unpublished data, thereby educating colleagues, promoting discussions and fostering collaborations. Specifically, the aims are to:1. Highlight the extraordinary progress being made in congenital platelet disorders. In 2000, the causative lesion was known for ~5% of these conditions. This is now more than 50%. The impact this knowledge is having on diagnosis, treatment and the opening up of novel therapeutic possibilities will be discussed.2. Disseminate the latest unpublished research linking the lineage to immunity and inflammation. It is increasingly apparent that platelets can promote inflammation, and that inflammation and infection can impact on hemostasis and trigger hemorrhage. This suggests a range of new therapeutic entry points that will be vigorously explored. 3. Promote the expanding field of platelets in cancer. This includes the role platelets play in mediating tumor metastasis, and the link between cancer-associated inflammation, elevated platelet production, and thrombosis. Despite decades of research, only now are some of the potential therapeutic entry points beginning to emerge. To achieve these aims, the 2017 GRC has made the following commitments: 1. In the earlier iterations of this meeting, sessions focused on platelets or megakaryocytes, and the meeting was essentially divided into two halves. For GRC 2017, the program intermixes sessions on megakaryocytes or platelets with sessions dealing with processes or diseases affecting/involving the lineage more broadly. 2. In 2017 we will be compressing the coffee breaks and trimming keynote speaker times to allow 12 talks to be selected from abstracts. Senior investigators will be kept absolutely to time, and the abstract talks will be intermixed with invited speakers so that attendance is maximized for junior investigators. 3. Multidisciplinarity will be emphasized, e.g. the session on the various approaches and technologies that are being brought to bear on congenital platelet disorders, including mapping, exome sequencing, and GWAS. 4. The therapeutic potential of the field in multiple areas will be tackled, with talks on c-Mpl mutations in myeloproliferative neoplasms, agents such as AURKA inhibitors in leukemia, and PI3K inhibitors in thrombosis.

项目概要/摘要 两年一度的戈登细胞生物学研究会议（GRC）和戈登研究研讨会（GRS） 巨核细胞和血小板研究中心汇集了现任领导者、初级研究人员和受训人员，致力于研究 巨核细胞谱系的发育和紊乱。这是全球首屈一指的国际会议 场地。正在进行的长期科学使命是弥合研究不同领域的研究人员之间的差距 谱系的各个方面，即干细胞、巨核细胞和血小板。这一使命比以往任何时候都更加重要 随着每种细胞类型之间的相互依赖性变得越来越清晰，例如巨核细胞的作用 干细胞发育，以及炎症对巨核细胞生长和血小板生成的影响。 GRC 的首要目标是让该领域的当前和新兴领导者进行交流 未发表的数据，从而教育同事、促进讨论和促进合作。 具体来说，目标是： 1．强调先天性血小板疾病方面取得的非凡进展。 2000 年，已知约 5% 的病症是由病变引起的。现在这个比例已经超过50%。影响 这些知识对诊断、治疗和开辟新的治疗可能性将是 讨论.2.传播将谱系与免疫和炎症联系起来的最新未发表的研究。它 越来越明显的是，血小板可以促进炎症，而炎症和感染可以 影响止血并引发出血。这表明了一系列新的治疗切入点 予以大力探索。 3.促进血小板在癌症领域的扩大。这包括血小板在介导肿瘤中发挥的作用 转移，以及癌症相关炎症、血小板生成升高和 血栓形成。尽管经过数十年的研究，直到现在才发现一些潜在的治疗切入点 开始出现。为实现这些目标，2017年GRC做出以下承诺： 1. 在本次会议的早期迭代中，会议重点关注血小板或巨核细胞，并且会议 基本上分为两半。对于 GRC 2017，该项目混合了有关巨核细胞的会议 或血小板，其中涉及更广泛地影响/涉及谱系的过程或疾病。 2. 2017 年，我们将压缩茶歇时间并缩短主题演讲时间，以允许 12 场演讲 从摘要中选择。高级调查员将绝对准时，抽象的谈话将在 与受邀演讲者混合在一起，以便最大限度地提高初级研究人员的出席率。 3. 强调多学科性，例如：会议讨论了各种方法和技术 对先天性血小板疾病产生影响，包括绘图、外显子组测序和 GWAS。 4. 将探讨该领域在多个领域的治疗潜力，并讨论 c-Mpl 突变 骨髓增殖性肿瘤、白血病中的 AURKA 抑制剂和血栓形成中的 PI3K 抑制剂等药物。