Novel Aberrometer for Wavefront Measurements

用于波前测量的新型像差计

• 批准号: 6585637
• 负责人: L John OTTEN
• 金额: $ 10.59万
• 依托单位: KESTREL CORPORATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6585637
• 关键词: bioimaging /biomedical imaging; brain imaging /visualization /scanning; cataract; clinical research; cornea disorder; diagnosis design /evaluation; eye disorder diagnosis; eye fundus photography; human subject; keratoconus; keratoplasty; measurement

DESCRIPTION (provided by applicant): A clinical instrument is needed for accurate, repeatable measurements of corneal aberrations in patients with significant anterior segment abnormalities, such as cataracts, keratoconus, corneal scarring from previous corneal surgery, for example and specifically, scarring caused by sutures from previous penetrating keratoplasty (PKP) Retinal photography for this same population of the patient cannot be easily accomplished due to the scintillation and scatter caused by cataracts or corneal aberrations Our approach uses a state-of-the-art, patented technique in wavefront sensors and adaptive optics to address this problem in eye care. A technology based on diffraction-grating wavefront sensing (DG WFS) has been demonstrated by Kestrel Corporation in laboratory tests. This application proposes to apply the DG WFS technology to a portion of the patient population base from which it is difficult to obtain quality retinal images or for whom it is a significant challenge to make topographical measurements due to corneal aberrations The aim of the project is to compare wavefront measurements using standard wavefront technology based on Shack-Hartmann sensors with our diffraction grating-based sensor The ability of the DG WFS to make measurements where the Shack-Hartmann sensor breaks down will be demonstrated on human subjects with significant anterior segment aberrations (cornea and lens) or corneal scarring The commercial application is significant A fundus imager that will produce high quality, high resolution images of subjects with significant anterior segment abnormalities, such as cataracts, will have high demand in a market that relies heavily on imaging for diagnostic information Topographic measurements of this same patient population also represent a significant commercial application.

DESCRIPTION (provided by applicant): A clinical instrument is needed for accurate, repeatable measurements of corneal aberrations in patients with significant anterior segment abnormalities, such as cataracts, keratoconus, corneal scarring from previous corneal surgery, for example and specifically, scarring caused by sutures from previous penetrating keratoplasty (PKP) Retinal photography for this same population of the patient cannot be easily accomplished due to the由白内障或角膜畸变引起的闪烁和散射我们的方法在波前传感器中使用最先进的专利技术，并在自适应光学上使用自适应光学器件来解决此问题。 Kestrel Corporation在实验室测试中已证明了基于衍射粒度波前传感（DG WF）的技术。该申请建议将DG WFS技术应用于患者人群的一部分，从中很难获得高质量的视网膜图像，或者由于角膜畸变而进行地形测量是一个重大挑战，该项目的目的是使用基于ShackMann传感器的标准波动技术来比较波前测量，以使我们的差异能力衡量DG，以使我们的差异能力使dg w ff Ff Ff Ff Ff FF FF FF F. Shack-Hartmann sensor breaks down will be demonstrated on human subjects with significant anterior segment aberrations (cornea and lens) or corneal scarring The commercial application is significant A fundus imager that will produce high quality, high resolution images of subjects with significant anterior segment abnormalities, such as cataracts, will have high demand in a market that relies heavily on imaging for diagnostic information Topographic measurements of this same patient population also represent重要的商业应用。