Novel Platform for Living Neural Networks

活神经网络的新颖平台

• 批准号: 6864349
• 负责人: DMITRI ROUTKEVITCH
• 金额: $ 7.53万
• 依托单位: SYNKERA TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-15 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6864349
• 关键词: aluminum; animal tissue; bioengineering /biomedical engineering; biomaterial compatibility; ceramics; electrical impedance; microelectrodes; nanotechnology; neural information processing; neurogenesis; neuronal guidance; neuropharmacology; synapses; tissue /cell culture; tissue support frame

DESCRIPTION (provided by applicant): Unlocking the mechanism of neural growth understanding and communication is needed for and treatment of many degenerative diseases, as well as for neural prosthesis and restoration of damaged neural connections. Living neural networks (LNN) can enable a broad array of new tools for neural research. Furthermore, LNNs, being capable of detect minute environmental perturbations, are an attractive target for chemical and biological sensing. However, producing reliable LNNs is challenging, and requires control over the neuronal growth and formation of synaptic junctions, high charge density high-resolution neuronal contacts, overall biocompatibility and reproducibility. Substrates for LNNs that would satisfy these requirements are not available. To address this opportunity we propose to use self-organized nanoporous alumina ceramic as a platform for guided growth and interfacing of LNNs. The core of the innovation is in the combination of several ideas: nanoengineering of the anodic alumina to provide tailored neuron/substrate interface; hybrid micro machining of patterns for neural growth guidance; using encapsulated nanoelectrodes arrays and routing the excitation/response signals to the bottom of the chip to provide soft high resolution electrical contacts to neurons. Proposed living neural networks have significant commercial potential. If realized, they could be used as tools for neural network research, disease studies and diagnostics, drug and toxin screening, and new generation of biochemical sensors.

描述（由申请人提供）：为许多退行性疾病以及神经假体和恢复受损的神经联系所需的神经生长理解和沟通的机制是必需的。活着的神经网络（LNN）可以为神经研究提供广泛的新工具。此外，LNN能够检测到微小的环境扰动，是化学和生物学传感的有吸引力的目标。但是，产生可靠的LNN是具有挑战性的，需要控制神经元的生长和突触连接的形成，高电荷密度高分辨率高分辨率神经接触，整体生物相容性和可重复性。无法满足这些要求的LNN的基材。为了解决这个机会，我们建议使用自组织的纳米氧化铝陶瓷作为LNN的指导增长和接口的平台。创新的核心是几种想法的结合：阳极氧化铝的纳米工程以提供量身定制的神经元/底物界面；神经生长指导的模式的混合微型加工；使用封装的纳米电极阵列并将激发/响应信号路由到芯片的底部，以向神经元提供柔软的高分辨率电触点。拟议的生活神经网络具有巨大的商业潜力。如果实现，它们可以用作神经网络研究，疾病研究和诊断，药物和毒素筛查以及新一代生化传感器的工具。