Evoked Potential Monitor for Traumatic Brain Injury

脑外伤诱发电位监测仪

• 批准号: 6645836
• 负责人: HONGXUAN ZHANG
• 金额: $ 19.48万
• 依托单位: INFINITE BIOMEDICAL TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6645836
• 关键词: brain disorder diagnosis; brain injury; diagnosis design /evaluation; evoked potentials; intracranial pressure; laboratory rat; nervous system disorder diagnosis; patient monitoring device; trauma

DESCRIPTION (provided by applicant): Traumatic Brain Injury (TBI) results in approximately 150,000 deaths per year in the United States. Most of the estimated 103,000 survivors are subjected to a prolonged hospital course and significant sequelae. TBI is associated with significant emotional distress for the patient and their family, and an economic burden of $48.3 billion per year to the nation. The consequences of TBI are rapid and devastating. There is a pressing need for reliable continuous neurological monitoring of such critical patients. Therefore, our Phase I goal is to investigate the use of quantitative Evoked Potential (qEP) analysis to detect and monitor the evolution of brain injury after TBI. We propose to develop a novel qEP system based on a powerful sinusoidal modeling algorithm known as ESPRIT. This system is intended to capture signal component changes due to injury. We will evaluate the ability of the qEP analysis to characterize acute cerebral injury, based on correlation with elevation of intracranial pressure and reduction of cerebral perfusion pressure in a rodent model. Further, we will observe the ability of qEP analysis to prognosticate the neurological outcome measured 72-hours after the introduction of an expansible mass lesion. If our Phase I effort is successful, we envision a Phase II effort focused on clinical validation of the technology. It is our long-term goal is to establish qEP analysis as a neurodiagnostic tool for improving the care of TBI victims.

描述（由申请人提供）：脑外伤（TBI）在美国每年约15万人死亡。估计有103,000名幸存者中的大多数经历了长时间的医院课程和明显的后遗症。 TBI与患者及其家人的严重情绪困扰有关，每年对全国的经济负担为483亿美元。 TBI的后果是迅速而毁灭性的。迫切需要对此类关键患者进行可靠的连续神经监测。因此，我们的I期目标是研究使用定量诱发电位（QEP）分析以检测和监测TBI后脑损伤的演变。我们建议开发一种基于强大的正弦建模算法的新型QEP系统，称为ESPRIT。该系统旨在捕获由于受伤而导致的信号组件变化。我们将根据与颅内压的升高以及啮齿动物模型中脑灌注压力的相关性，评估QEP分析表征急性脑损伤的能力。此外，我们将观察QEP分析预测在引入可扩展的肿块病变后72小时测量的神经系统结局的能力。 如果我们的第一阶段努力成功，我们设想了一项侧重于该技术临床验证的II期努力。我们的长期目标是建立QEP分析作为改善TBI受害者护理的神经诊断工具。