Brief Alcohol Intervention in HIV+ Women

对艾滋病毒女性的简短酒精干预

• 批准号: 6698306
• 负责人: MARY E MCCAUL
• 金额: $ 34.09万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-25 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6698306
• 关键词: AIDS therapy; alcoholism /alcohol abuse; alcoholism /alcohol abuse therapy; behavioral /social science research tag; breath tests; clinical research; comorbidity; counseling; female; helper T lymphocyte; high risk behavior /lifestyle; human immunodeficiency virus; human subject; human therapy evaluation; patient oriented research; peer group; quality of life; questionnaires; sex behavior; sign /symptom; social support network; substance abuse related behavior; therapy compliance; urinalysis; virus load

DESCRIPTION (provided by applicant): Heavy alcohol use impacts HIV/AIDS in several important ways. It increases HIV-risk behaviors, impairs the immune system and accelerates HIV and other disease progression, and interferes with HIV care compliance. Women are particularly important targets for alcohol use interventions. Heavy/hazardous alcohol use is less likely to be detected in women in health care settings. The threshold for harmful alcohol effects is strikingly low in women, with two drinks per day placing women at risk for negative health consequences. Also, women may be less likely to seek and engage in alcohol treatment services, making nontraditional care settings particularly important for reaching this population. This proposal tests the utility of a brief alcohol intervention delivered in a medical setting for HIV+ women. Hazardous/binge female drinkers will be identified in the Johns Hopkins Hospital HIV Clinic and will be randomized to brief intervention or standard care. Brief intervention will include four 30-minute contacts delivered by a trained therapist. Outcome measures will include: alcohol/drug use, engagement in a weekly on-site support group or other alcohol treatment services, HIV-risk behaviors, HIV disease markers and treatment compliance, psychiatric symptoms and quality of life. Primary aims are to examine alcohol use, HIV-risk behaviors, HIV treatment compliance and disease progression and quality of life in women receiving the brief intervention compared to women receiving standard care. Secondary aims include: determination of the prevalence of hazardous/heavy drinking in this population; and characterization of the effects of heavy alcohol use on HIV disease progression in women. Brief interventions are being applied in a wide variety of health care settings. This study will provide information on a practical and easily applied intervention for the particularly vulnerable population of HIV+ women.

描述（由申请人提供）：大量饮酒以几种重要方式影响艾滋病毒/艾滋病。它增加了艾滋病毒风险行为，损害免疫系统并加速艾滋病毒和其他疾病进展，并干扰艾滋病毒护理的依从性。妇女是饮酒干预措施的特别重要目标。在卫生保健环境中，妇女在妇女中发现大量/危险的饮酒的可能性较小。女性的有害酒精效应的门槛非常低，每天两杯饮料使妇女面临负面健康后果的风险。而且，妇女可能不太可能寻求和从事酒精治疗服务，这使得非传统护理环境对于吸引该人群尤为重要。该提案测试了在艾滋病毒+妇女的医疗环境中进行的短暂酒精干预效用。约翰·霍普金斯医院的艾滋病毒诊所将确定有害/暴饮暴食的女性饮酒者，并将随机分配以进行简短的干预或标准护理。简短的干预将包括四个由训练有素的治疗师提供的30分钟联系人。结果指标将包括：酒精/吸毒，参与每周的现场支持小组或其他酒精治疗服务，艾滋病毒风险行为，艾滋病毒疾病标志和治疗依从性，精神病症状和生活质量。与接受标准护理的妇女相比，主要目的是检查接受短暂干预的妇女的饮酒，艾滋病毒治疗依从性以及接受短暂干预的妇女的疾病进展和生活质量。次要目的包括：确定该人群中危险/大量饮酒的率；以及大量饮酒对女性艾滋病毒疾病进展的影响的表征。短暂的干预措施正在各种医疗保健环境中。这项研究将为特别脆弱的艾滋病毒+女性提供有关实用且易于应用干预的信息。