Mediators and Moderators of Auditory Training

听觉训练的中介者和调节者

• 批准号: 10462160
• 负责人: FREDERICK J. GALLUN
• 金额: $ 0.91万
• 依托单位: UNIVERSITY OF CALIFORNIA RIVERSIDE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-01-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462160
• 关键词: 3-Dimensional; Address; Age; Aging; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Assessment tool; Auditory; Auditory Threshold; Basic Science; Behavior Therapy; Behavioral; Central Auditory Diseases; Characteristics; Cognition; Cognitive; Collection; Communication; Computer software; Cues; Data Set; Dementia; Detection; Development; Elderly; Environment; Face; Frustration; Funding; Goals; Hearing; Hearing Aids; Human; Impaired cognition; Individual; Individual Differences; Lead; Literature; Long-Term Effects; Measures; Mediator of activation protein; Methods; Mission; Modeling; Music; National Institute of Child Health and Human Development; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; National Institute on Alcohol Abuse and Alcoholism; Outcome; Outcome Measure; Participant; Perceptual learning; Performance; Peripheral; Personal Satisfaction; Personality; Persons; Population; Procedures; Process; Psychophysics; Public Health; Publishing; Quality of life; Rehabilitation therapy; Reporting; Reproducibility; Research; Research Personnel; Risk; Sample Size; Sampling; Source; Speech; Stimulus; Structure; Tablets; Testing; Training; Translational Research; Translations; United States National Institutes of Health; Withdrawal; Work; auditory processing; base; cognitive ability; comparison group; demographics; experience; functional independence; hearing impairment; interest; middle age; prodromal Alzheimer' s disease; recruit; skills; social; sound; tool; young adult

This proposal seeks to understand mechanisms of auditory training (AT) and potential of AT to mitigate hearing issues that promote risk of development of Alzheimer’s disease and related dementias (ADRD). Reports from the Lancet Commission (Livingstone and colleagues, 2020), and others, show midlife hearing loss is one of the greatest predictors of late-life dementia, and hearing aids protect against development of ADRD. While this has promoted a push for greater distribution of hearing aids, research from Gates and colleagues (2011) suggests that central hearing processes may be greater predictors of onset of ADRD than peripheral hearing (as addressed through hearing aids). Central auditory processing abilities are fundamental to understand speech, appreciate music, and separate competing environmental sound sources. Hearing challenges experienced with increasing age, especially understanding speech in noisy ambient environments, cause frustration with interpersonal verbal communication and detrimental long-term effects on functional independence, cognitive abilities, and overall quality of life, including increased risk for ADRD. Nevertheless, despite extensive research conducted across multiple fields, clinicians and researchers still disagree about the best ways to address the diversity of hearing difficulties individuals face throughout their lives. The guiding premise of the current proposal is the need for robust and reliable data sets to clarify the underlying mechanisms of AT and to identify the mediators and moderators that impact training outcomes. The overarching goal of this proposal is that better understanding of mechanisms of AT, with focus on speech in competition, can address the most prevalent hearing complaints reported by people as they age, and in turn mitigate transition to ADRD. To address this, we will recruit a large and diverse sample of older adults, including those with prodromal ADRD, and a comparison group of younger adults (1260 participants across training conditions, including separate samples of young and older adults). We will research how baseline cognitive and hearing measures predict training outcomes (moderators) and how these interact with training methods (mediators). To enhance rigor and reproducibility, we will release data sets and training/assessment tools to enable other researchers to conduct analyses, replicate our studies, and test their own training methods using common outcome measures. The proposed research will address four Specific Aims. Aim 1 – Determine the relationship of stimulus complexity and AT outcomes. Aim 2 – Determine the relationship of AT training structures and AT outcomes. Aim 3 – Determine relationships between participant characteristics (moderators) and AT approaches (mediators) on training outcomes. Aim 4 – Create an AT platform that facilitates faithful replication and modelling. Through the collection and dissemination of a large, unique, and comprehensive dataset, this proposal has potential for transformative impact by clarifying moderators and mediators of AT, and will afford translational opportunities to contribute to the mitigation of hearing and cognitive decline in individuals who may be at risk for the development of ADRD.

该提案旨在了解听觉训练的机制（AT）以及AT的潜力减轻听力问题，从而促进了阿尔茨海默氏病和相关痴呆症（ADRD）的发展风险。柳叶刀委员会（Livingstone及其同事，2020年）和其他人的报告显示，中年听力损失是后期痴呆症的最大预测因素之一，助听器辅助辅助防止ADRD的发展。尽管这促进了助听器分配的推动力，但Gates及其同事（2011年）的研究表明，中央听力过程可能比外围听力（通过助听器解决）更大的ADRD发作预测指标。中央听觉处理能力是了解语音，欣赏音乐和独立竞争性环境音响的基础。随着年龄的增长而遇到的听力挑战，尤其是在嘈杂的环境环境中了解语音，引起人际言语交流和对功能独立性，认知能力和整体生活质量的长期影响的真菌，包括对ADRD的风险增加。然而，在多个领域进行的拼命广泛的研究，临床医生和研究人员仍然不同意解决人们一生所面临的听力困难多样性的最佳方法。当前建议的指导信念是需要强大而可靠的数据集，以阐明AT的基本机制并确定影响培训结果的中介者和主持人。该提案的总体目标是，更好地理解AT的机制，重点是竞争中的语音，可以解决人们随着年龄的增长而报告的最普遍的听力投诉，进而减轻过渡到ADRD。为了解决这个问题，我们将招募大量多样化的老年人样本，包括前瞻性ADRD的老年人，以及一个比较组的年轻人（包括跨培训条件的1260名参与者，包括单独的年轻和老年人样本）。我们将研究基线认知和听力措施如何预测培训结果（主持人）以及这些如何与训练方法（调解人）相互作用。为了增强严格性和可重复性，我们将释放数据集和培训/评估工具，以使其他研究人员能够使用共同的成果指标进行分析，复制我们的研究并测试自己的培训方法。拟议的研究将解决四个具体目标。目标1 - 确定刺激复杂性的关系和结果。目标2 - 确定训练结构和结果的关系。 AIM 3 - 确定参与特征（主持人）与训练结果的方法（调解人）之间的关系。目标4 - 创建一个促进忠实复制和建模的平台。通过收集和传播一个大型，独特和全面的数据集，该提案具有通过Clariifyify的主持人和AT的中介者的变革影响的潜力，并将提供转化的机会，以减轻可能有ADRD风险的人的听力和认知能力下降。