Omics of Lung Diseases

肺部疾病组学

• 批准号: 9284511
• 负责人: Jeffrey A Whitsett
• 金额: $ 32.64万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9284511
• 关键词: Adult; Bioinformatics; Biology; Biomedical Engineering; Biomedical Research; Career Choice; Childhood; Clinical; Computational Science; Databases; Development; Diagnosis; Doctor of Medicine; Doctor of Philosophy; Educational Curriculum; Engineering; Environmental Health; Epidemiology; Epigenetic Process; Future; Genetic; Genomics; Knowledge; Lung; Lung diseases; Medical; Medical Research; Medical center; Medicine; Mentors; Metabolism; NCI Scholars Program; Pediatric Hospitals; Physicians; Proteins; Proteomics; Pulmonology; Recruitment Activity; Request for Proposals; Research; Research Personnel; Research Training; SECTM1 gene; Schools; Science; Scientist; Teacher Professional Development; Technology; Temperament; Training; Training Programs; Underrepresented Minority; Universities; Wages; base; biological research; biomedical informatics; career; career development; college; experience; high throughput technology; interest; metabolomics; programs; skills

DESCRIPTION (provided by applicant): This new K12 proposal requests support for 1-2 years of salary support to develop independent investigators with skills that integrate computational sciences and pulmonary medicine. M.D., Ph.D. or M.D./Ph.D. candidates will be recruited based on their commitments to biomedical research careers, their excellence in scholarly and medical training, and their interest in pulmonary disease, to be mentored in a program that will provide expertise in biomedical informatics and the "omics" at the University of Cincinnati College of Medicine (UCCOM), the University of Cincinnati School of Engineering (UC), and Cincinnati Children's Hospital Medical Center (CCHMC). The scholars program will provide didactic experience, research training, and career pathway support to optimize their development as independent investigators with the integrated skills needed to apply the "omics" to pulmonary disease. The program brings together highly a committed training faculty within a program that will integrate outstanding clinician-scientists expert in pediatric and adult pulmonary medicine, with scientists in environmental health, pulmonary biology, bioengineering, bioinformatics, and other computational science. Use and interpretation of proteomics, genomics, clinical bioinformatics, lipidomics, metabolomics, and genetics will provide the framework for the training experience. Program Aims: 1) Attract, recruit, and advance career development of the highest quality applicants to the "pulmonary omics" program, including underrepresented minorities; 2) To further develop and apply a highly organized training program that will include didactic and direct research experience in a curriculum that will bridge knowledge regarding pulmonary biology and medicine with computational and technological skills that are needed to optimally train the pulmonary investigators for their future careers as biomedical and physician-scientists; and 3) To train and develop career paths for investigators who will become leaders in the field of pulmonary medicine. Rationale: There is compelling need for career development of young investigators who are well trained in quantitative biomedical sciences and pulmonary disease. Rapid expansion of enabling technologies, whether in use of clinical databases, bioinformatics, epidemiology, genomics, epigenetics, protein sciences and metabolism, has created unparalleled opportunities to advance knowledge related to pulmonary medicine. The training experience and temperament of young investigators choosing medical and biological research are often quite distinct from those choosing computational-based sciences. It is increasingly apparent that advances in high-throughput technology and computational abilities provide fertile support for synergizing discoveries that will transform the diagnosis and treatment of pulmonary disease. The present K12 application seeks to create transdisciplinary opportunities for career development, bridging computational sciences and technology related to high-throughput platforms with pulmonary medicine and biology.

描述（由申请人提供）：这项新的 K12 提案要求提供 1-2 年的薪资支持，以培养具有整合计算科学和肺医学技能的独立研究人员。医学博士、博士或医学博士/博士候选人将根据他们对生物医学研究事业的承诺、他们在学术和医学培训方面的卓越表现以及他们对肺部疾病的兴趣而被招募，并在一个项目中接受指导，该项目将提供生物医学信息学和“组学”方面的专业知识。辛辛那提医学院 (UCCOM)、辛辛那提大学工程学院 (UC) 和辛辛那提儿童医院医疗中心 (CCHMC)。学者计划将提供教学经验、研究培训和职业道路支持，以优化他们作为独立研究人员的发展，并具备将“组学”应用于肺部疾病所需的综合技能。该项目汇集了高度忠诚的培训教师，将儿科和成人肺医学方面的杰出临床科学家专家与环境健康、肺生物学、生物工程、生物信息学和其他计算科学方面的科学家结合起来。蛋白质组学、基因组学、临床生物信息学、脂质组学、代谢组学和遗传学的使用和解释将为培训经验提供框架。计划目标： 1) 吸引、招募和促进最高质量申请人加入“肺组学”计划，包括代表性不足的少数群体； 2) 进一步制定和应用高度组织化的培训计划，其中包括课程中的教学和直接研究经验，将肺部生物学和医学知识与计算和技术技能联系起来，以最佳地培训肺部研究人员的未来职业生涯作为生物医学和医学科学家； 3) 为将成为肺医学领域领导者的研究人员提供培训和发展职业道路。理由：迫切需要在定量生物医学科学和肺部疾病方面受过良好培训的年轻研究人员的职业发展。支持技术的快速扩展，无论是使用临床数据库、生物信息学、流行病学、基因组学、表观遗传学、蛋白质科学和新陈代谢，都为推进肺医学相关知识创造了无与伦比的机会。选择医学和生物学研究的年轻研究人员的培训经历和气质往往与选择基于计算的科学的年轻研究人员截然不同。越来越明显的是，高通量技术和计算能力的进步为协同发现提供了丰富的支持，从而改变了诊断和治疗 肺部疾病。目前的 K12 应用程序旨在为职业发展创造跨学科机会，将与高通量平台相关的计算科学和技术与肺医学和生物学联系起来。

项目成果

Ground-glass burden as a biomarker in neuroendocrine cell hyperplasia of infancy.

毛玻璃负荷作为婴儿神经内分泌细胞增生的生物标志物。

• 发表时间: 2019
• 影响因子: 3.1
• 作者: Spielberg, David R;Brody, Alan S;Baker, Michael L;Woods, Jason C;Towe, Christopher T
• 通讯作者: Towe, Christopher T

Quantitative CT scans of lung parenchymal pathology in premature infants ages 0-6 years.

0-6 岁早产儿肺实质病理的定量 CT 扫描。

• 发表时间: 2018
• 影响因子: 3.1
• 作者: Spielberg, David R;Walkup, Laura L;Stein, Jill M;Crotty, Eric J;Rattan, Mantosh S;Hossain, Md Monir;Brody, Alan S;Woods, Jason C
• 通讯作者: Woods, Jason C