Effect of Alcohol Use on Waterpipe Smoking Patterns and Toxicant Exposure

饮酒对水烟吸烟模式和有毒物质暴露的影响

基本信息

批准号：
9192802
负责人：
Eleanor Ladd Schneider Leavens
金额：
$ 4.31万
依托单位：
OKLAHOMA STATE UNIVERSITY STILLWATER
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-15 至 2018-08-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9192802
关键词：
Acute Address Air Alcohol consumption Alcohols Aromatic Polycyclic Hydrocarbons Benzene Breathing Carbon Monoxide Cardiovascular Diseases Cardiovascular system Charcoal Cigarette Communities Crossover Design Dependence Drug Interactions Equilibrium Exhalation Exposure to Flavoring Foundations Health Heating Heavy Metals Hour Investigation Knowledge Laboratory Study Learning Literature Lung diseases Maintenance Malignant Neoplasms Measures Mediating Methods Nicotine Outcome Patient Self-Report Pattern Pharmaceutical Preparations Placebo Control Placebos Plasma Public Health Randomized Reporting Research Role Sales Serum Smoke Smoker Smoking Smoking Behavior Tars Time Tobacco Tobacco use Toxicant exposure Training Water abstracting alcohol abstinence alcohol effect cigarette smoking cigarette smoking drinking experience hookah innovation interdisciplinary collaboration novel primary outcome respiratory satisfaction secondary outcome smoke inhalation social tobacco abstinence toxicant willingness young adult

项目摘要

Project Title: Effect of Alcohol Use on Waterpipe Smoking Patterns and Toxicant Exposure Project Summary/ Abstract: Waterpipe (WP) smoking in the US is on the rise and beginning to overtake cigarettes as the most popular method of tobacco use among young adults. Unfortunately, WP smoking is associated with many of the same negative health outcomes as cigarettes such as cancer, lung disease, respiratory illness, and cardiovascular disease. The co-occurrence of alcohol use and WP smoking is quite common among young adults. Relative to those who do not use WP, WP smokers are estimated to be more than twice as likely to use alcohol and frequently consume alcohol immediately before or during a WP smoking session. Of concern, the cigarette smoking literature suggests that smokers smoke more cigarettes when they drink alcohol and have a more difficult time abstaining from smoking, resulting in more exposure to nicotine and tobacco-related toxicants. These findings cannot be directly applied to WP smoking due to unique aspects of WP smoking (e.g., smoking patterns, smoke may be easier to inhale, WP is typically smoked in groups). To date, no study has experimentally and systematically investigated the impact of alcohol on WP smoking behaviors, resultant exposure to tobacco-related toxicants, or abuse liability. The proposed study will provide this needed scientific evidence. Using a randomized crossover-design, 40 current WP smokers will complete two counterbalanced WP smoking sessions (alcohol vs. placebo) that are preceded by 24 hours of alcohol abstinence and 12-hour tobacco abstinence. Sessions will be separated by a standard 48-hour washout period, and WP tobacco nicotine levels will be held constant across sessions. Measures of smoking behavior (puff topography) and acute toxicant exposure (CO boost and plasma nicotine) will be collected, in addition to self-report measures of abuse liability, intentions for continued use, and importance of concurrent alcohol consumption for using WP. If alcohol consumption were determined to influence users to initially try WP, increase their willingness to continue to use the product, and/or make it more palatable to puff more frequently or take longer/deeper puffs, then concurrent alcohol use would be contributing to the initiation and maintenance of WP dependence. This innovative study, in its systematic examination of the impact of co-use of alcohol and WP, will provide the scientific foundation needed to establish effective regulatory strategies for the distribution and sales of WP tobacco and alcohol. In addition, this project will serve as an incredibly valuable training experience by providing an opportunity to learn new assessments of WP smoking and drug-drug interactions while learning from leading experts in the field of WP smoking and gaining an appreciation for interdisciplinary collaboration.

项目名称：饮酒对水烟吸烟模式和有毒物质暴露的影响项目摘要/摘要：在美国，吸水烟 (WP) 的人数呈上升趋势，并开始超过香烟，成为最受欢迎的吸食者年轻人使用烟草的方法。不幸的是，WP 吸烟与许多相同的症状有关。香烟带来的负面健康后果，如癌症、肺部疾病、呼吸系统疾病和心血管疾病疾病。在年轻人中，饮酒和吸烟同时发生是很常见的。相对于据估计，那些不使用 WP 的人，吸烟者使用酒精的可能性是吸烟者的两倍以上，在 WP 吸烟之前或期间经常饮酒。值得关注的是，香烟吸烟文献表明，吸烟者在饮酒时会吸更多的香烟，而且吸烟量也更大。戒烟困难，导致更多地接触尼古丁和烟草相关毒物。由于 WP 吸烟的独特方面（例如，吸烟），这些发现不能直接应用于 WP 吸烟模式，烟雾可能更容易吸入，WP 通常是分组吸烟）。迄今为止，还没有研究通过实验和系统研究酒精对 WP 吸烟行为的影响，结果接触与烟草有关的毒物，或有滥用的倾向。拟议的研究将提供所需的科学依据证据。使用随机交叉设计，40 名当前 WP 吸烟者将完成两项平衡 WP 吸烟疗程（酒精与安慰剂），之前 24 小时戒酒并 12 小时戒烟。会议将被标准的 48 小时清洗期分开，并且 WP 烟草尼古丁水平将在整个会议期间保持恒定。吸烟行为的测量（吸烟形态）和除了自我报告措施外，还将收集急性毒物暴露（CO 刺激和血浆尼古丁）滥用倾向、继续使用的意图以及同时饮酒对使用 WP 的重要性。如果确定饮酒会影响用户最初尝试 WP，增加他们的意愿继续使用该产品，和/或使其更可口地更频繁地抽吸或更长/更深地抽吸，那么同时饮酒将导致 WP 依赖的产生和维持。这创新研究，在系统地检查酒精和可湿性粉剂共同使用的影响时，将提供为可湿性粉剂的分销和销售制定有效的监管策略需要科学基础烟草和酒精。此外，该项目将成为非常有价值的培训经验提供在学习的同时学习对 WP 吸烟和药物相互作用的新评估的机会来自 WP 吸烟领域的领先专家，并获得跨学科合作的赞赏。