Predictors of Menarche

初潮的预测因素

• 批准号: 6743092
• 负责人: LINDSAY A FRAZIER
• 金额: $ 6.46万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-26 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6743092
• 关键词: adolescence (12-20); age difference; behavioral /social science research tag; body composition; body physical activity; breast neoplasms; clinical research; data collection methodology /evaluation; disease /disorder proneness /risk; early experience; female; human birth weight; human data; human puberty; longitudinal human study; menstrual cycle; middle childhood (6-11); neoplasm /cancer epidemiology; nutrient intake activity; nutrition; nutrition related tag; obesity; weight gain

DESCRIPTION (provided by applicant): Younger age at menarche is a strong risk factor for breast cancer. For each year of decline in age at menarche, risk of breast cancer has been estimated to increase 4%. In most developed countries, age at menarche has declined, on average, 3 months per decade over the last century, whereas in developing countries, the decline has been more rapid. Postulated reasons for the younger age at menarche include improved nutrition, lower levels of physical activity and the concomitant rise in obesity. Understanding the impact of physical activity has been hampered by crude measurement, however, and studies to date have not examined rigorously the relative impact of physical activity versus weight. To examine the impact of physical activity on onset of menarche, we will use data from the Growing Up Today Study (GUTS) a longitudinal study of 16,882 children who have completed annual surveys since inception of the study in 1996 when they were 9-14 years of age. Using age at onset of menses as our outcome, we will examine the impact of physical activity, independent of the effect of body weight. We will also examine the effects of overweight and inactivity, and their effect modification, on timing of menses. Understanding the predictors of menarche will help to develop a public health approach to the issue of early pubertal development.

描述（由申请人提供）： 初潮年龄较小是乳腺癌的一个重要危险因素。据估计，初潮年龄每降低一年，患乳腺癌的风险就会增加 4%。在大多数发达国家，初潮年龄在上个世纪平均每十年下降 3 个月，而在发展中国家，下降速度更快。初潮年龄较年轻的假定原因包括营养改善、体力活动水平较低以及随之而来的肥胖率上升。然而，粗略的测量阻碍了对体育活动影响的理解，迄今为止的研究尚未严格检验体育活动与体重的相对影响。为了研究体力活动对初潮的影响，我们将使用“今日成长研究”(GUTS) 的数据，该研究对 16,882 名儿童进行了纵向研究，自 1996 年该研究开始以来，这些儿童已完成年度调查，当时他们的年龄为 9-14 岁的年龄。使用月经开始的年龄作为我们的结果，我们将检查身体活动的影响，而与体重的影响无关。我们还将研究超重和缺乏活动及其影响修改对月经时间的影响。了解初潮的预测因素将有助于制定解决青春期早期发育问题的公共卫生方法。