Short silk nanofibre based 3D scaffolds with enhanced biomimicry

具有增强仿生性的基于短丝纳米纤维的 3D 支架

• 批准号: LP140100287
• 负责人: Prof Xungai Wang
• 金额: $ 33.16万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-02-16 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP140100287
• 关键词: Short; silk; nanofibre; based; 3D

This project aims to understand the behaviour of haematopoietic stem cells (HSC) in novel 3D scaffolds based on short silk nanofibres. This will lead to highly functional 3D scaffolding materials that support efficient HSC renewal in vitro. This project aims to overcome the key problem with existing in vitro systems, which lack the morphological and biochemical complexities of native HSC-niche. Since haematopoietic stem cells are the precursors to all blood cells, this project has the potential of engineering a high yield artificial ‘blood factory’, which will help save the lives of many thousands of people who rely on bone marrow transplants to treat life-threatening illness such as leukaemia.

该项目旨在了解造血干细胞 (HSC) 在基于短丝纳米纤维的新型 3D 支架中的行为，这将产生支持 HSC 体外高效更新的高功能性 3D 支架材料。现有的体外系统缺乏天然 HSC 生态位的形态和生化复杂性，由于造血干细胞是所有血细胞的前体，因此该项目具有设计高产量人工造血干细胞的潜力。 “血液工厂”，这将有助于挽救成千上万依靠骨髓移植来治疗白血病等危及生命的疾病的人的生命。