2016 DNA Damage, Mutation and Cancer Gordon Research Conference & Gordon Research Seminar

2016 DNA 损伤、突变和癌症戈登研究会议

基本信息

批准号：
9050225
负责人：
SERGEI MIRKIN
金额：
$ 0.6万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-02-17 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9050225
关键词：
Base Excision Repairs Biochemical Biochemistry Boxing California Cancer Etiology Chromosomal Rearrangement Chromosome Fragility Collaborations Communication Complex DNA DNA Damage DNA Repair DNA Structure DNA lesion Development Discipline Disease Environment Equilibrium Genes Genome Genome Stability Genomic Instability Genomics Goals Growth Health Healthcare Heart Hereditary Disease Human Learning Light Link Maintenance Malignant Neoplasms Molecular Molecular Genetics Mutagenesis Mutation Normal Cell Other Genetics Participant Pathway interactions Patients Postdoctoral Fellow Process Proteins RNA Regulation Research Research Personnel Resolution Scientist Source Structure Unstable DNA Sequence Work abstracting anticancer research base cancer cell cancer genetics cancer genomics cancer risk cancer therapy career chemotherapy chromothripsis cohort data sharing faculty mentor genome sequencing graduate student insertion/deletion mutation interest meetings molecular oncology multidisciplinary neoplastic cell next generation oxidative DNA damage peer posters repaired response structural biology symposium

项目摘要

DESCRIPTION (provided by applicant): The 2016 Gordon Conference on DNA Damage, Mutation & Cancer will present cutting-edge research on the molecular mechanisms responsible for the recognition and processing of environmental DNA damage as well as inherently unstable DNA sequences. Multiple biochemical mechanisms recognize DNA lesions or difficult to unravel DNA structures, ultimately yielding a choice of pathways for resolution. Competing and collaborating DNA repair mechanisms are at the heart of a delicate balance between inherent genomic stability and instability in health and disease. Understanding these mechanisms is crucial for developing next generation anti-cancer therapies that will take advantage of genotypic differences between normal cells and tumor cells. These front-line scientific topics will be discussed in the conference's nine sessions provisionally entitled: Inherent Genomic Stability and Instability; Genome Weak Links; Environmental Genomic Damage; RNA-DNA Interplay in Genome Instability; Oxidative DNA damage and Base Excision Repair; Mutagenesis in Response to Arrested Replication; Checkpoints and Strand-Break Repair; FoSTeS, Kataegis and Chromothripsis; and Emerging Chemotherapies Based on Cancer Genomics. Our invited speakers represent a variety of scientific disciplines, including molecular genetics, biochemistry, structural biology and molecular oncology. The Conference will bring together a diverse group of researchers with broad backgrounds and interests stimulating new research and collaborations. It will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field, as well as the possibility to attend the inaugural two-day Gordon Research Seminar, which precede the Conference. Some poster presenters will be selected for late-breaking short talks. We anticipate that intense scientific interactions during this conference will impact cancer research in many significant ways and result in establishing productive multi-disciplinary research collaborations. The 2016 DNA Damage, Mutation & Cancer Gordon Research Conference will be held at the Ventura Beach Marriott, in Ventura, California March 13 - 18, 2016.

描述（由申请人提供）：2016 年戈登 DNA 损伤、突变和癌症会议将介绍负责识别和处理环境 DNA 损伤的分子机制以及识别固有不稳定 DNA 序列的前沿研究。 DNA 损伤或难以解开的 DNA 结构，最终产生解决途径的选择竞争和协作的 DNA 修复机制是健康和疾病中固有基因组稳定性与不稳定性之间微妙平衡的核心。开发下一代抗癌疗法，利用正常细胞和肿瘤细胞之间的基因型差异，这些前沿科学主题将在会议的九场会议上讨论，暂定标题为：固有基因组稳定性和不稳定性；基因组损伤；基因组氧化损伤和碱基切除修复中的相互作用；检查点和链断裂修复； FoSTeS、Kataegis 和 Chromothripsis；以及基于癌症基因组学的新兴化疗。我们邀请的演讲者代表了各个科学学科，包括分子遗传学、生物化学、会议将汇集具有广泛背景和兴趣的多元化研究人员，激发新的研究和合作，为初级科学家和研究生提供以海报形式展示其工作并与领域领导者交流想法的机会。我们预计，本次会议期间激烈的科学互动将影响癌症研究。在许多重要方面并导致建立生产力2016 年 DNA 损伤、突变和癌症戈登研究会议将于 2016 年 3 月 13 日至 18 日在加利福尼亚州文图拉的文图拉海滩万豪酒店举行。