Methods and Analysis

方法与分析

• 批准号: 10208657
• 负责人: Eve Van Cauter
• 金额: $ 20.27万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10208657
• 关键词: Aging; Algorithms; Animals; Archives; Attention; Back; Biological; Biometry; Blood Cells; Blood Pressure; Blood specimen; Cardiovascular system; Chicago; Clinical; Code; Collection; Complement; Computational Biology; Computer software; Consultations; Data; Data Analyses; Data Collection; Detection; Doctor of Philosophy; Electroencephalography; Ensure; Event; Experimental Designs; Future; Gene Expression; Gene Expression Profile; Genes; Genetic; Glucose; Glucose tolerance test; Grant; Hormonal; Hour; Human; Individual; Intervention; Label; Laboratories; Life; Measurement; Measures; Metabolic; Methods; Modeling; OGTT; Pattern; Peripheral; Polysomnography; Procedures; Protein Isoforms; Quality Control; Records; Research Personnel; Rodent; Rosemary; Sampling; Scientist; Series; Services; Signal Transduction; Site; Sleep; Standardization; Statistical Data Interpretation; Time; Tissues; Training; Training Support; Transcript; Universities; Update; analytical method; analytical tool; cardiometabolism; circadian; circadian pacemaker; computerized; computerized tools; conditioning; data archive; data exchange; data format; data privacy; data repository; data sharing; design; digital; electronic data; encryption; experience; genome-wide; heart rate variability; interstitial; medical schools; neurobehavioral; neurobehavioral test; next generation; novel; originality; professor; programs; psychologic; reference genome; repository; statistics; tool; transcriptome sequencing

The Methods and Analysis Core will have five main functions and serve all three projects of the Program Project. A first function of the Core will be to continue to implement and update standard operating procedures for the collection of PSG signals, metabolic measures, cardiovascular measures, hormonal profiles and neurobehavioral tests. Particular attention will be paid to adequate time synchronization with the other biological and psychological measurements. A second function of Core B will be to establish and manage a shared data repository to centralize digital records (PSG, cardiometabolic, hormonal and neurobehavioral measures) obtained during the past and current project periods. The repository will be located on a server at the University of Chicago and all project investigators will have remote access using encrypted authentication. A third function of Core B will be to provide specific computerized analytical tools (PRANA software, Chronobiological Series Analyzer (CSA), Minimal Model Software [MiniMod], Templates for analysis of oral glucose tolerance tests) for the scoring of human and animal sleep-wake stages, the edition of sleep transient events, and the analysis of hormonal, cardiovascular, genetic and metabolic data. Fourth, the Core will develop new computerized tools for analyzing temporal profiles of gene expression. Lastly, Core B will provide expert statistical support to the different projects. The functions served by the Methods and Analysis Core will greatly enhance the overall quality, originality and quantity of the data collected in the individual projects.

方法和分析核心将具有五个主要功能，并为程序的所有三个项目提供服务 项目。核心的第一个功能将是继续实施和更新标准操作程序 用于收集PSG信号，代谢措施，心血管措施，荷尔蒙轮廓和 神经行为测试。特别关注与其他生物学的足够时间同步 和心理测量。核心B的第二个功能是建立和管理共享 数据存储库以集中数字记录（PSG，心脏代谢，荷尔蒙和神经行为措施） 在过去和当前项目期间获得。存储库将位于大学的服务器上 芝加哥和所有项目调查人员将使用加密身份验证进行远程访问。第三个功能 B核B将提供特定的计算机分析工具（Prana软件，计时生物学系列 分析仪（CSA），最小模型软件[minimod]，用于分析口服葡萄糖耐量测试的模板） 为了进行人类和动物睡眠阶段的评分，睡眠瞬态事件的版本和分析 荷尔蒙，心血管，遗传和代谢数据。第四，核心将开发新的计算机 分析基因表达时间谱的工具。最后，核心B将为专家统计支持 不同的项目。方法和分析核心提供的功能将大大增强整体 各个项目中收集的数据的质量，独创性和数量。