CADENCE-Adults: Cadence and Intensity Across the Adult Lifespan

节奏-成人：整个成人寿命的节奏和强度

• 批准号: 9086181
• 负责人: CATRINE E. TUDOR-LOCKE
• 金额: $ 45.85万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9086181
• 关键词: 20 year old; Accelerometer; Adult; Age; Attenuated; Biological Neural Networks; Biomedical Research; Categories; Child; Classification; Clinic; Clinical; Complex; Controlled Study; Data; Data Set; Development; Devices; Digit structure; Electronics; Equation; Exercise stress test; Frustration; Gait; Goals; Health; Label; Laboratories; Left; Length; Life; Literature; Longevity; Measures; Metabolic; Methods; Monitor; Movement; Output; Oxygen; Participant; Pattern; Pattern Recognition; Physical activity; Pilot Projects; Positioning Attribute; Process; Public Health; Recruitment Activity; Reporting; Signal Transduction; Source; Speed; Statistical Models; Technology; Testing; Time; Translating; Videotape; Walking; Woman; age group; base; cost; design; experience; heuristics; innovation; instrument; inter-individual variation; markov model; men; programs; real world application; standard measure; treadmill; trend; uptake; user-friendly; walking speed; yearning

 DESCRIPTION (provided by applicant): CADENCE-Adults is an R01 study that will calibrate cadence (steps/min) and intensity in 260 ambulatory adults, 10 men and 10 women for each 5-year age-group category between 21-85 years, effectively covering the adult lifespan. Cadence is one of the temporal-spatial parameters of gait. Cadence multiplied by stride length equals speed. Capture and expression of objectively monitored physical activity in terms of cadence represents an overlooked opportunity to represent free-living patterns of ambulatory intensity. There is merit in being able to "translate" technological and analytical advances into more accessible terms, especially if public health goals are to be realized. Cadence represents a minimally processed and translatable metric that could be collected and interpreted across objective instruments, including those used in the lab, in the clinic, and in the real world. The primary aim of CADENCE-Adults is to identify objectively observed (video-taped) and manually counted cadence (steps/min) criterion cut points associated with markers of increasing intensity across age groupings. A secondary aim is to compare multiple instruments' abilities to accurately detect criterion values for cadence at different speeds and thus better inform our confidence in comparing this metric across instruments. To achieve these aims, cadence and oxygen uptake data will be collected during a treadmill assessment of incrementally faster paces and also using portable metabolic testing of common free- living activities to test the primary hypothesis: Activity intensity (oxygen uptake) will increase in a linear or nonlinear (curvilinear) fashion as cadence increases such that we will be able to develop statistical models for predicting markers (cut points) of intensity from cadence. We are uniquely positioned at the Pennington Biomedical Research Center to successfully conduct CADENCE-Adults as designed in a 5-year time period. We have conducted pilot testing demonstrating the feasibility of this project, established recruiting methods, and are fully experienced in exercise testing, accelerometry, and management of large complex data sets. We expect that cadence cut points established in CADENCE-Adults will be used both to assess ambulatory intensity, but also to inform program design focused on increasing not only the volume of physical activity (e.g., steps/day) but also its intensity (e.g., cadence) in user-friendly metrics. No similar data exist a this time so the approach described in this application is both innovative and critical to providin a minimally processed and translatable objectively monitored metric with established cut points across the lifespan.

 描述（由申请人提供）： CADENCE-Adults 是一项 R01 研究，将校准 260 名可行走的成年人（21-85 岁之间每个 5 岁年龄组类别 10 名男性和 10 名女性）的步频（步数/分钟）和强度，有效覆盖成人寿命的步频是步态的时空参数之一。以节奏来捕捉和表达客观监测的身体活动代表了自由生活强度模式的机会，能够将技术和分析的进步“转化”为更容易理解的术语是有好处的，尤其是在公共场合。 Cadence 代表了一种经过最少处理和可翻译的指标，可以通过客观仪器（包括实验室、诊所和现实世界中使用的仪器）进行收集和解释。 CADENCE-Adults 的主要目标是。识别客观观察（录像）和手动计算的步频（步数/分钟）标准切点，与各年龄段强度增加的标记相关。第二个目的是比较多种仪器准确检测步频标准值的能力。为了实现这些目标，我们将在跑步机评估逐渐加快的步速期间收集步频和摄氧量数据，并使用常见自由生活活动的便携式代谢测试来收集步频和摄氧量数据。测试主要假设：随着节奏的增加，活动强度（摄氧量）将以线性或非线性（曲线）方式增加，这样我们就能够开发统计模型来预测节奏的强度标记（切点）。在彭宁顿生物医学研究中心，我们在 5 年时间内成功开展了 CADENCE-Adults，我们已经进行了试点测试，证明了该项目的可行性，建立了招募方法，并且在运动测试方面拥有丰富的经验，我们期望 CADENCE-Adults 中建立的步频切点不仅可以用于评估步行强度，还可以为旨在增加体力活动量（例如步数）的计划设计提供信息。 /天），而且还有用户友好指标中的强度（例如节奏），这次不存在类似的数据，因此该应用程序中描述的方法对于提供最少的处理和可翻译既是创新的也是关键的。在整个生命周期内建立切点来客观地监控指标。