CHILDRENS CANCER GROUP

儿童癌症组

基本信息

批准号：
2087473
负责人：
ROBERT J WELLS
金额：
$ 15.85万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
1979
资助国家：
美国
起止时间：
1979-07-01 至 1998-11-30
项目状态：
已结题

项目摘要

The objective of this proposal is to improve the diagnosis, treatment and outcome of children with cancer through participation in protocols designed by the Childrens Cancer Groups (CCG). We plan to enter eligible patients on CCG protocols, participate in the development and execution of these protocols, supply materials for and execute biological studies of cancer through CCG, serve as a referral center for other CCG institutions which lack facilities for bone marrow transplantation or for phase I chemotherapy and to perform independent studies which may serve as the basis for future CCG studies. The Children's Hospital Medical Center (CHMC) is the major pediatric medical center in the greater Cincinnati area with a population of 2 million people. CHMC is the only hospital wit pediatric inpatient capabilities within a 50 to 75 mile radius of Cincinnati and is one of the three largest pediatric medical centers, within the United States. There are four medical centers affiliate with CHMC: the University of Kentucky, Lexington, KY; Children's Hospital of Akron, Akron, OH; the Penn State University Children's Hospital, Hershey, PA; and Scottish Rite Children's Hospital, Atlanta, GA. Combined, they served population areas of another 8 to 10 million people. Together, we have become the second largest contributor of patients to CCG studies. Personnel from CHMC and its affiliates have made many contributions to the administration of the CCG and to its scientific studies. Highlights of this participation include personnel serving as Associate Chair for Leukemia Studies, member of the Executive Committee of the CCG, Chair of the AML strategy Group, Vice Chair of numerous strategy groups and leading study committees. CHMC provides the CCG with one of its oldest and largest pediatric Bone Marrow Transplantation units. This unit has expanded from 5 to 8 beds in the past five years and will be expanded to 12 beds when our new clinical tower is completed in January of 1994. This unit has been particularly active in transplantation of patients with neuroblastoma, acute myeloid leukemia and brain tumors. CHMC also became one of the relatively few phase I institutions during the past five years adding to the CCG's capability to perform these unique and difficult studies. We have also been a leading contributor to cancer biologic studies, the second leading contributor to the Human Tumor Tissue Network and have served as a center for pediatric tumor xenografts which allow completion of additional studies of the biology of these tumors.

该提议的目的是改善诊断，治疗和癌症儿童通过参与方案的结果由儿童癌组（CCG）设计。我们计划进入符合条件 CCG方案的患者参与开发和执行在这些方案中，提供生物学研究材料和执行材料通过CCG癌症，作为其他CCG的转诊中心缺乏骨髓移植设施或 I期化学疗法并进行独立研究作为未来CCG研究的基础。儿童医院医疗中心（CHMC）是主要的儿科大辛辛那提地区的医疗中心人口为2 百万人。 CHMC是唯一一家Wit Cediotric Hothot 辛辛那提半径为50至75英里的功能，是之一美国境内三个最大的儿科医疗中心。 CHMC有四个分支机构：肯塔基州，肯塔基州列克星敦；俄亥俄州阿克伦的阿克伦儿童医院；这宾夕法尼亚州赫尔希的宾夕法尼亚州立大学儿童医院；和苏格兰仪式佐治亚州亚特兰大儿童医院。他们合并为人口领域另外8至1000万人。在一起，我们已经成为第二 CCG研究患者的最大贡献者。 CHMC及其分支机构的人员为 CCG及其科学研究的管理。亮点此参与包括担任副主席的人员白血病研究，CCG执行委员会成员，主席 AML战略小组，众多战略小组的副主席，领先的学习委员会。 CHMC为CCG提供了其最古老，最大的儿科骨头之一骨髓移植单位。该单元已从5张床扩展到8张在过去的五年中临床塔在1994年1月完成。该单元已经特别活跃于神经母细胞瘤患者的移植中急性髓样白血病和脑肿瘤。 CHMC也成为在过去五年中，相对较少的I期机构增加了 CCG执行这些独特且困难的研究的能力。我们也是癌症生物学研究的主要贡献者，人类肿瘤组织网络的第二大贡献者，并具有作为小儿肿瘤异种移植物的中心，允许完成这些肿瘤生物学的其他研究。