CHILDREN'S CANCER STUDY GROUP

儿童癌症研究小组

• 批准号: 3556806
• 负责人: ROBERT J WELLS
• 金额: $ 12.31万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-07-01 至 1993-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3556806
• 关键词: Wilms' tumor; acute leukemia; acute lymphocytic leukemia; adenosine deaminase; athymic mouse; autoradiography; biological response modifiers; bone marrow transplantation; bone neoplasms; brain neoplasms; cancer information system; cancer registry /resource; cancer rehabilitation /care; cellular oncology; combination cancer therapy; combination chemotherapy; cooperative study; cyclophosphamide; cytogenetics; cytosine arabinoside; doxorubicin; drug adverse effect; drug metabolism; human subject; human therapy evaluation; methotrexate; myelogenous leukemia; neoplasm /cancer chemotherapy; neoplasm /cancer diagnosis; neoplasm /cancer epidemiology; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; oncology nursing; pediatric neoplasm /cancer; rhabdomyosarcoma; tissue /cell culture; vincristine

The overall objective of this proposal is to improve the diagnosis, treatment and rehabilitation of children with cancer through participation in protocols designed by Children's Cancer Study Group. Specifically, we plan to enter eligible patients on CCSG protocols, participate in development of protocols, participate in doing biologic studies and supplying biologic materials, serve as a referral center for patients requiring bone marrow transplantation and do independent research studies which may serve as a background for group wide studies in the future. The Children's Hospital Medical Center is the major pediatric center within a 50-75 mile radius of Cincinnati and is the only pediatric unit within Cincinnati. There are four other pediatric centers that are affiliates of CHMC: University of Kentucky, Akron Children's Hospital, Hershey Medical Center and Scottish Rite Hospital in Atlanta. CHMC and the affiliates have a multidisciplinary approach to the evaluation and treatment of cancer in children and are one of the largest contributors of patients on CCSG protocols. Personnel from CHMC and the affiliates are contributing heavily to the scientific endeavors of CCSG by participating through Strategy Groups and Committees which are studying Acute Non-Lymphocytic Leukemia, Relapsed Acute Lymphocytic Leukemia, Non-Hodgkin's Lymphoma, Neuroblastoma, Wilm's Tumor, Brain Tumors, Bone Tumors and Bone Marrow Transplantation. The Bone Marrow Transplant Unit at CHMC is one of the largest, oldest and most active of the units participating in CCSG studies. The capacity of this unit will be expanded further during the next five years both in physical space and in personnel. CHMC is also helping to advance biologic studies of CCSG by banking solid tumors from CCSG institutions by freezing tissue and injecting tumor tissue in nude mice. This tissue will be available for research studies as determined by the Biology Committee of CCSG. Certainly investigators at CHMC will be one of the CCSG institutions using this material for cytogenetic and molecular genetic studies.

该提案的总体目的是改善诊断， 通过治疗和修复癌症儿童 参与儿童癌症研究设计的方案 团体。 具体而言，我们计划在CCSG上输入合格的患者 协议，参与协议的制定，参与 进行生物学研究和提供生物学材料，作为 需要骨髓的患者推荐中心 移植并进行可以服务的独立研究 作为未来小组研究的背景。 儿童医院医疗中心是主要的儿科 辛辛那提半径为50-75英里的中心，是唯一的 辛辛那提内的小儿单位。 还有其他四个小儿 CHMC分支机构的中心：肯塔基大学，阿克伦大学 儿童医院，好时医学中心和苏格兰仪式 亚特兰大的医院。 CHMC和分支机构有一个 评估和治疗的多学科方法 儿童的癌症，是最大的贡献者之一 CCSG方案的患者。 来自CHMC和分支机构的人员 正在为CCSG的科学努力做出重大贡献 通过战略小组和委员会参与 研究急性非淋巴细胞白血病，复发性急性淋巴细胞 白血病，非霍奇金淋巴瘤，神经母细胞瘤，威尔姆肿瘤， 脑肿瘤，骨肿瘤和骨髓移植。 CHMC的骨髓移植单元是最大的骨髓移植单元之一 参加CCSG研究的最古老，最活跃的单位。 该单元的容量将在下一个期间进一步扩大 在物理空间和人员中都有五年的时间。 CHMC还通过银行业务帮助推进CCSG的生物学研究 通过冷冻组织和CCSG机构的实体瘤 在裸鼠中注射肿瘤组织。 该组织可用 用于由生物学委员会确定的研究 CCSG。 当然，CHMC的调查人员将是CCSG之一 使用该材料进行细胞遗传学和分子的机构 遗传研究。