Respiratory Diseases and Exposure to Elongated Mineral Particles in Taconite Ore

呼吸道疾病和接触铁燧岩矿石中的细长矿物颗粒

• 批准号: 8842034
• 负责人: Gurumurthy Ramachandran
• 金额: $ 41.04万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8842034
• 关键词: Respiratory; Diseases; Exposure; Elongated; Mineral

Project Summary/Abstract There is a lack of well-defined studies regarding the health effects of non-asbestiform elongated mineral particles (EMPs), and a lack of agreement on the appropriate threshold dimensions of EMPs that are health- relevant. The NIOSH Roadmap for Research relating to asbestos fibers and other EMPs (2011) identifies the taconite miners of northeastern Minnesota as a population that should be studied further with detailed exposure characterization. We aim to address the question of health effects of non-asbestiform EMPs, and also the various hypotheses regarding the appropriate dimensions of the EMPs that may be relevant to respiratory health. A previous study has collected large number of personal filter samples that have been analyzed for EMPs using NIOSH 7400/7402. All these personal samples obtained have also been archived for future use. We first propose to re-analyze these samples using ISO TEM 13794 that will provide detailed information on dimension, mineralogy, and habit, and obtain estimates of personal exposures using different dimension-based exposure metrics. Second, we will develop and validate similarly exposed groups (SEGs) based on these exposure metrics. Third, we will obtain relationships (conversion factors) between the different exposure metrics for each SEG, and apply these conversion factors to the historical data to obtain exposure histories of each SEG according to these exposure metrics. Fourth, we will use the estimated exposure histories and employment histories of each worker in the cohort to calculate their cumulative exposures according to each exposure metric. Fifth, we will estimate the risk of mesothelioma, lung cancer and prevalent non-malignant respiratory disease associated with those exposures, both by themselves and in the presence of respirable dust and silica exposures. For this purpose, a large cohort of workers has been assembled with health outcome data with increasing levels of specificity- mortality, incidence of lung cancer, indicators of respiratory morbidity - spirometry, chest X-rays, etc. that have already been collected. This information along with the exposure measurements will be used to address the question of health effects of non-asbestiform EMPs, and also the various hypotheses regarding the appropriate dimensions of the EMPs that may be relevant to respiratory health

项目概要/摘要 关于非石棉状细长矿物质对健康的影响缺乏明确的研究 粒子（EMP），以及对影响健康的 EMP 的适当阈值尺寸缺乏一致意见。 相关的。 NIOSH 与石棉纤维和其他电磁脉冲相关的研究路线图 (2011) 确定了 明尼苏达州东北部的铁燧岩矿工作为一个群体，应该进一步进行详细研究 曝光表征。我们的目标是解决非石棉类电磁脉冲对健康的影响问题，以及 还有关于 EMP 的适当维度的各种假设，这些假设可能与 呼吸系统健康。之前的一项研究收集了大量的个人过滤器样本，这些样本已被 使用 NIOSH 7400/7402 分析 EMP。所有这些获得的个人样本也已存档 未来使用。我们首先建议使用 ISO TEM 13794 重新分析这些样本，该标准将提供详细信息 有关尺寸、矿物学和习惯的信息，并使用不同的方法获得个人暴露的估计值 基于维度的曝光指标。其次，我们将开发并验证类似暴露群体 (SEG) 基于这些曝光指标。第三，我们将获得不同之间的关系（转换因子） 每个SEG的曝光指标，并将这些转换因子应用于历史数据以获得曝光 根据这些暴露指标的每个 SEG 的历史记录。第四，我们将使用估计暴露 队列中每个工人的历史和就业历史，以计算他们的累积暴露 根据每个曝光指标。第五，我们将估计间皮瘤、肺癌和流行病的风险 与这些暴露相关的非恶性呼吸道疾病，无论是其本身还是存在 呼吸性粉尘和二氧化硅暴露。为此，集结了一大批工作人员 健康结果数据的特异性越来越高——死亡率、肺癌发病率、指标 呼吸道疾病 - 已收集的肺活量测定、胸部 X 光检查等。此信息随 暴露测量将用于解决非石棉类物质对健康的影响问题 EMP，以及有关可能的 EMP 适当维度的各种假设 与呼吸系统健康相关