Respiratory Diseases and Exposure to Elongated Mineral Particles in Taconite Ore

呼吸道疾病和接触铁燧岩矿石中的细长矿物颗粒

基本信息

批准号：
9381087
负责人：
Gurumurthy Ramachandran
金额：
$ 21.9万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-16 至 2018-07-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9381087
关键词：
Respiratory Diseases Exposure Elongated Mineral

项目摘要

DESCRIPTION (provided by applicant): There is a lack of well-defined studies regarding the health effects of non-asbestiform elongated mineral particles (EMPs), and a lack of agreement on the appropriate threshold dimensions of EMPs that are health- relevant. The NIOSH Roadmap for Research relating to asbestos fibers and other EMPs (2011) identifies the taconite miners of northeastern Minnesota as a population that should be studied further with detailed exposure characterization. We aim to address the question of health effects of non-asbestiform EMPs, and also the various hypotheses regarding the appropriate dimensions of the EMPs that may be relevant to respiratory health. A previous study has collected large number of personal filter samples that have been analyzed for EMPs using NIOSH 7400/7402. All these personal samples obtained have also been archived for future use. We first propose to re-analyze these samples using ISO TEM 13794 that will provide detailed information on dimension, mineralogy, and habit, and obtain estimates of personal exposures using different dimension-based exposure metrics. Second, we will develop and validate similarly exposed groups (SEGs) based on these exposure metrics. Third, we will obtain relationships (conversion factors) between the different exposure metrics for each SEG, and apply these conversion factors to the historical data to obtain exposure histories of each SEG according to these exposure metrics. Fourth, we will use the estimated exposure histories and employment histories of each worker in the cohort to calculate their cumulative exposures according to each exposure metric. Fifth, we will estimate the risk of mesothelioma, lung cancer and prevalent non-malignant respiratory disease associated with those exposures, both by themselves and in the presence of respirable dust and silica exposures. For this purpose, a large cohort of workers has been assembled with health outcome data with increasing levels of specificity- mortality, incidence of lung cancer, indicators of respiratory morbidity - spirometry, chest X-rays, etc. that have already been collected. This information along with the exposure measurements will be used to address the question of health effects of non-asbestiform EMPs, and also the various hypotheses regarding the appropriate dimensions of the EMPs that may be relevant to respiratory health

描述（由申请人提供）：缺乏关于非石棉状细长矿物颗粒（EMP）对健康影响的明确研究，并且对与健康相关的 EMP 的适当阈值尺寸缺乏一致意见。 NIOSH 与石棉纤维和其他电磁脉冲相关的研究路线图（2011 年）将明尼苏达州东北部的铁燧岩矿工确定为一个应进一步研究并详细描述暴露特征的人群。我们的目标是解决非石棉样电磁脉冲对健康的影响问题，以及有关可能与呼吸系统健康相关的电磁脉冲适当尺寸的各种假设。之前的一项研究收集了大量个人过滤器样本，并使用 NIOSH 7400/7402 对这些样本进行了电磁脉冲分析。所有这些获得的个人样本也已存档以备将来使用。我们首先建议使用 ISO TEM 13794 重新分析这些样本，该标准将提供有关尺寸、矿物学和习惯的详细信息，并使用不同的基于尺寸的暴露指标获得个人暴露的估计。其次，我们将根据这些暴露指标来开发和验证类似暴露群体 (SEG)。第三，我们将获得每个SEG的不同曝光指标之间的关系（转换因子），并将这些转换因子应用于历史数据，以根据这些曝光指标获得每个SEG的曝光历史。第四，我们将使用队列中每个工人的估计暴露历史和就业历史，根据每个暴露指标计算他们的累积暴露。第五，我们将估计与这些暴露相关的间皮瘤、肺癌和流行的非恶性呼吸道疾病的风险，无论是其本身还是在存在可吸入粉尘和二氧化硅暴露的情况下。为此，一大批工作人员收集了健康结果数据，这些数据的特异性水平不断提高——死亡率、肺癌发病率、呼吸系统发病指标——肺活量测定、胸部 X 光检查等。该信息与暴露测量一起将用于解决非石棉状电磁脉冲对健康影响的问题，以及有关可能与呼吸系统健康相关的电磁脉冲适当尺寸的各种假设

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Reconstructing Historical Exposures to Respirable Dust and Respirable Silica in the Taconite Mining Industry for 1955-2010.

重建 1955-2010 年铁燧岩采矿业中可吸入粉尘和可吸入二氧化硅的历史暴露情况。

DOI：
发表时间：
2022-04-22
期刊：
影响因子：
0
作者：
Shao, Yuan;Hwang, Jooyeon;MacLehose, Richard F;Alexander, Bruce H;Mandel, Jeffrey H;Raynor, Peter C;Ramachandran, Gurumurthy
通讯作者：
Ramachandran, Gurumurthy

Reconstructing historical exposures to elongate mineral particles (EMPs) in the taconite mining industry for 1955-2010.

重建 1955-2010 年铁燧岩采矿业中细长矿物颗粒 (EMP) 的历史暴露。

DOI：
发表时间：
2019
期刊：
影响因子：
2
作者：
Shao, Yuan;Hwang, Jooyeon;Alexander, Bruce H;Mandel, Jeffrey H;MacLehose, Richard F;Ramachandran, Gurumurthy
通讯作者：
Ramachandran, Gurumurthy

A Bayesian Approach for Determining the Relationship Between Various Elongate Mineral Particles (EMPs) Definitions.

用于确定各种细长矿物颗粒 (EMP) 定义之间关系的贝叶斯方法。

DOI：
发表时间：
2020
期刊：
影响因子：
0
作者：
Shao, Yuan;MacLehose, Richard F;Lin, Lifeng;Hwang, Jooyeon;Alexander, Bruce H;Mandel, Jeffrey H;Ramachandran, Gurumurthy
通讯作者：
Ramachandran, Gurumurthy