DEVICE FOR TREATMENT OF NEONATAL CHEST RETRACTIONS

治疗新生儿胸部收缩的装置

• 批准号: 2234957
• 负责人: CHARLES PALMER
• 金额: $ 10万
• 依托单位: MEDELEX, INC.
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2234957
• 关键词: biomedical equipment development; clinical biomedical equipment; clinical research; human subject; human therapy evaluation; newborn human (0-6 weeks); respirators

A device providing continuous negative distending pressure will be tested in preterm neonates suffering from retractions due to respiratory distress to determine effects on 1) chest wall distortion and 2) improvement in ventilation. The neonate's compliant chest allows the chest to collapse during inspiration, decreasing respiratory efficiency. The proposed devise will prevent retractions and decrease the work of breathing. The device offers advantages over current neonatal respiratory care techniques because it will avert the problems associated with positive pressure ventilation such as bronchopulmonary dysplasia and intraventricular hemorrhage. Whole body plethysmography, face mask pneumotachography and inductive plethysmography will be used to non-invasively and continuously monitor pulmonary function and chest/abdomen synchrony. Following a period of baseline measurements, the device will be applied for a duration of two hours during which time quantitative measurements of pulmonary function, cardiovascular parameters and thoracoabdominal asynchrony, will be stored for later analysis. It is anticipated that the device will provide significant relief to developing neonates by preventing atelectasis without high mean airway pressure, increasing gas exchange and reducing work of breathing. This lo- cost device may aid in reduction of the length of patient stay and help reduce the cost of hospitalization. Proposed Commercial Application: There are two potential commercial applications of this research, (a) a chest brace and device that passively provides a low-cost, non-invasive means of alleviating respiratory distress in neonates; (b) a chest brace device that provides active ventilation to neonates.

将测试提供持续负膨胀压力的装置 因呼吸窘迫而出现回缩的早产儿 确定对 1) 胸壁扭曲和 2) 改善的影响 通风。 新生儿的胸部顺应性允许胸部在分娩过程中塌陷 吸气，降低呼吸效率。 拟议的装置将 防止回缩并减少呼吸做功。 该设备提供 与当前新生儿呼吸护理技术相比具有优势，因为它 将避免与正压通气相关的问题，例如 如支气管肺发育不良和脑室内出血。 全身体积描记法、面罩呼吸描记法和感应式 体积描记法将用于无创、连续监测 肺功能和胸/腹部同步性。 经过一段时间的 基线测量，该设备将被应用两个持续时间 定量测量肺功能的时间， 心血管参数和胸腹异步，将被存储 以供以后分析。 预计该设备将显着缓解 在没有高平均气道的情况下通过预防肺不张来发育新生儿 压力，增加气体交换并减少呼吸功。 这个洛 成本设备可能有助于减少患者住院时间并帮助 减少住院费用。 拟议的商业应用：有两个潜在的商业应用 这项研究的应用，（a）一个胸托和装置，被动地 提供一种低成本、非侵入性的缓解呼吸窘迫的方法 新生儿； (b) 提供主动通气的胸托装置 新生儿。