DEVICE FOR TREATMENT OF NEONATAL CHEST RETRACTIONS

治疗新生儿胸部收缩的装置

• 批准号: 2234957
• 负责人: CHARLES PALMER
• 金额: $ 10万
• 依托单位: MEDELEX, INC.
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2234957
• 关键词: biomedical equipment development; clinical biomedical equipment; clinical research; human subject; human therapy evaluation; newborn human (0-6 weeks); respirators

A device providing continuous negative distending pressure will be tested in preterm neonates suffering from retractions due to respiratory distress to determine effects on 1) chest wall distortion and 2) improvement in ventilation. The neonate's compliant chest allows the chest to collapse during inspiration, decreasing respiratory efficiency. The proposed devise will prevent retractions and decrease the work of breathing. The device offers advantages over current neonatal respiratory care techniques because it will avert the problems associated with positive pressure ventilation such as bronchopulmonary dysplasia and intraventricular hemorrhage. Whole body plethysmography, face mask pneumotachography and inductive plethysmography will be used to non-invasively and continuously monitor pulmonary function and chest/abdomen synchrony. Following a period of baseline measurements, the device will be applied for a duration of two hours during which time quantitative measurements of pulmonary function, cardiovascular parameters and thoracoabdominal asynchrony, will be stored for later analysis. It is anticipated that the device will provide significant relief to developing neonates by preventing atelectasis without high mean airway pressure, increasing gas exchange and reducing work of breathing. This lo- cost device may aid in reduction of the length of patient stay and help reduce the cost of hospitalization. Proposed Commercial Application: There are two potential commercial applications of this research, (a) a chest brace and device that passively provides a low-cost, non-invasive means of alleviating respiratory distress in neonates; (b) a chest brace device that provides active ventilation to neonates.

提供连续负面压力的设备将被测试 在早产新生儿因呼吸窘迫引起的缩回 确定对1）胸壁失真和2）改进的影响 通风。 新生儿的符合胸部使胸部在 灵感，降低呼吸效率。 拟议的设计将 防止缩回并减少呼吸的工作。 设备提供 优于当前新生儿呼吸护理技术，因为它 将避免与正压通风相关的问题 作为支气管肺发育不良和脑室内出血。 全身杂质学，面膜肺炎和归纳性 整数学将用于非侵入性和连续监测 肺功能和胸部/腹部同步。 一段时间 基线测量值，该设备将持续两次 在此期间，肺功能的定量测量值 心血管参数和胸腔异步，将存储 用于以后的分析。 预计该设备将为 通过防止肺不张力而没有高平均气道来发展新生儿 压力，增加气体交换并减少呼吸工作。 这个 成本设备可能有助于减少患者住宿的时间和帮助 降低住院费用。 拟议的商业应用：有两个潜在的商业 这项研究的应用，（a）一个被动的胸托和设备 提供低成本，无创的减轻呼吸窘迫的手段 在新生儿； （b）提供主动通风的胸托设备 新生儿。