The New York City Collaborative Regional Coordinating Stroke Center

纽约市协作区域中风协调中心

基本信息

批准号：
9128725
负责人：
LAURA BALCER
金额：
$ 36.96万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-30 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9128725
关键词：
Academic Medical Centers Acute Address Adult Agreement Ambulatory Care Facilities Area Awareness Blood Vessels Caring Cessation of life Childhood Clinical Clinical Trials Cohort Studies Collaborations Communities Development Enrollment Epidemiologic Studies Epidemiology Epigenetic Process Ethnic Origin Evaluation Future Gender Health Health Professional Hispanics Hospitals Institutes Institution Institutional Review Boards Israel Laboratories Latino Lead Leadership Link Low income Medical Medical center Medicine Methodology Minority Recruitment Modeling Morbidity - disease rate Multi-Institutional Clinical Trial Municipal Hospitals Myocardial Infarction National Institute of Neurological Disorders and Stroke Neurologist Neurology Neurosciences New York New York City Outcome Patients Pediatrics Phase Population Prevention Primary Prevention Principal Investigator Protocols documentation Race Readiness Recovery Recruitment Activity Rehabilitation Centers Rehabilitation therapy Research Research Infrastructure Research Personnel Resources Risk Risk Factors Site Stroke Stroke prevention Structure System Teaching Hospitals Training and Education Translations Underrepresented Minority Universities Ursidae Family Woman acute stroke base cohort college design disability experience follower of religion Jewish improved innovation medical schools meetings mortality multidisciplinary next generation north shore long island novel strategies phase II trial phase III trial programs response retention rate school health screening stroke treatment success

项目摘要

DESCRIPTION (provided by applicant): Stroke remains a leading cause of mortality, morbidity and disability with gradients in all three outcomes by race-ethnicity and gender. Lower SES groups, including Blacks and Hispanics, suffer a disproportionately high burden of risk, disability and death from stroke, myocardial infarction and associated vascular risk factors. Until recently there has been a dearth of Phase 2 and 3 clinical trials for stroke, and those that have been undertaken have mostly focused only on acute stroke treatment. Additionally, many of these trials were unable to meet trial enrollment targets and had poor recruitment of underrepresented minorities and women. As new stroke treatment approaches emerge, both from neuroscience laboratories and from epidemiologic cohort studies, rapid translation requires the efficient design and implementation of clinical trials in this area. We are responding to RFA-NS-13-011: NINDS Stroke Trials Network-Regional Coordinating Stroke Centers (RCC) with the overall aim to establish a collaborative network that brings together three major urban academic medical centers and their affiliates. The Centers bring with them three large CTSA's and an extensive network system to leverage clinical expertise and research infrastructure to provide multidisciplinary support to maximize the efficient development, promotion, and conduct of high quality multi- site clinical trials, with a focus on stroke prevention, treatment and rehabilitation/recovery in both adult and pediatric populations. The centers include the Albert Einstein College of Medicine (AECOM), Icahn School of Medicine at Mount Sinai (ISMMS), and New York University School of Medicine (NYU). Additionally, Hofstra-North Shore-Long Island Jewish Medical School and Health System together with their network institutions and affiliates. New York City Health and Hospitals Corporation (HHC) facilities; Continuum Health Partners facilities (Beth Israel Medical Center, St. Luke's/Roosevelt Hospital Center); and Maimonides Medical Center join NYCC-RCC as affiliate institutions. Three rehabilitation hospitals, including the preeminent Rusk Institute at NYU, Beth Abraham at Einstein and the Rehabilitation Center at ISMMS are also key network partners.

描述（由申请人提供）：中风仍然是死亡、发病和残疾的主要原因，所有三种结果均按种族、民族和性别存在梯度。社会经济地位较低的群体，包括黑人和西班牙裔，承受着不成比例的高风险、残疾负担中风、心肌梗塞和相关血管危险因素导致的死亡。直到最近，中风的 2 期和 3 期临床试验还很缺乏，而且已经进行的临床试验大多只集中于急性中风治疗。此外，其中许多试验无法达到试验入组目标，并且对代表性不足的少数族裔和妇女的招募情况不佳。随着新的中风治疗方法从神经科学实验室和流行病学队列研究中出现，快速转化需要有效的设计并实施该领域的临床试验。我们正在回应 RFA-NS-13-011：NINDS 卒中试验网络-区域卒中协调中心 (RCC)，总体目标是建立一个将三个主要城市学术医疗中心及其附属机构聚集在一起的协作网络。这些中心拥有三个大型 CTSA 和广泛的网络系统，可利用临床专业知识和研究基础设施提供多学科支持，最大限度地有效开发、推广和开展高质量的多中心临床试验，重点关注中风预防、成人和儿童群体的治疗和康复/康复。这些中心包括阿尔伯特·爱因斯坦医学院 (AECOM)、西奈山伊坎医学院 (ISMMS) 和纽约大学医学院 (NYU)。此外，霍夫斯特拉-北岸-长岛犹太医学院和卫生系统及其网络机构和附属机构。纽约市健康与医院公司 (HHC) 设施； Continuum Health Partners 设施（贝斯以色列医疗中心、圣卢克/罗斯福医院中心）；和迈蒙尼德医疗中心作为附属机构加入 NYCC-RCC。三个康复医院，包括著名的纽约大学腊斯克研究所、爱因斯坦医院的贝丝亚伯拉罕医院和 ISMMS 康复中心，也是重要的网络合作伙伴。