Pulse oximetry for childhood pneumonia in rural Bangladesh

孟加拉国农村儿童肺炎的脉搏血氧测定法

• 批准号: 9119892
• 负责人: Eric Douglass McCollum
• 金额: $ 14.13万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9119892
• 关键词: Age; Antibiotic Therapy; Antibiotics; Asia; Asians; Bangladesh; Bangladeshi; Biostatistical Methods; Breathing; Caring; Case Management; Cessation of life; Child; Child Care; Child health care; Childhood; Clinical; Clinical Investigator; Clinical Research; Collaborations; Communities; Community Health; Community Healthcare; Complication; Coughing; Country; Data; Decision Making; Developed Countries; Developing Countries; Diagnosis; Diagnostic; Enrollment; Epidemiology; Failure; Foundations; Funding; Goals; Health; Health Personnel; Healthcare; Heart Rate; Home environment; Hospitalized Child; Hospitals; International; Intervention Trial; Lead; Literature; Malawi; Measurement; Measures; Medical; Mentored Research Scientist Development Award; Mentors; Modeling; Monitor; Nutritional status; Oral; Outcome; Oxygen; Patients; Peripheral; Pneumococcal vaccine; Pneumonia; Public Health Schools; Pulmonology; Pulse Oximetry; Quality of Care; Recruitment Activity; Research; Research Design; Research Personnel; Resources; Respiration; Risk; Role; Rural; Science; Scientist; Severities; Severity of illness; Specialist; Technology; Temperature; Treatment Failure; Triage; Upper arm; Vaccination; Vaccines; World Health Organization; aged; base; diagnosis quality; experience; improved; instrument; international center; mortality; multidisciplinary; professor; programs; respiratory; skills; support tools; tool

DESCRIPTION (provided by applicant): This is a submission for a Fogarty International Center K01 International Research Scientist Development Award for Dr. Eric D. McCollum, a pediatric pulmonologist at the Johns Hopkins Eudowood Division of Pediatric Respiratory Sciences. Dr. McCollum is a junior clinical investigator in the field of childhood respiratory illnesses in low-resource countries. This K01 award will provide Dr. McCollum with the support needed to achieve the following objectives: (1) to become an expert in clinical research implementation and management in Asian resource-limited settings; (2) to develop skills in advanced study design and biostatistical methods; and (3) formulate multidisciplinary, long-distance collaborations with pediatric pulmonologists. To accomplish these objectives, Dr. McCollum has crafted a mentoring team including a US primary mentor, Dr. Abdullah Baqui, Professor in the International Health Department of Johns Hopkins Bloomberg School of Public Health, an international leader of child health in low-resource Asian countries, and a Bangladesh primary mentor, Dr. Dipak Mitra, Assistant Scientist in the International Health Department of Johns Hopkins Bloomberg School of Public Health and a child health expert based in Bangladesh, as well as four co-mentors; Drs. Katherine O'Brien and Bareng Aletta Sanny Nonyane, experts in child respiratory epidemiology and analysis, respectively; and Drs. Pamela Zeitlin and William Checkley, both specialists in pulmonology. Pneumonia is the number one cause of childhood death globally as well as in Asia. Dr. McCollum's research will leverage the ongoing multicenter Pneumococcal Vaccine Impact study to evaluate pulse oximetry as a pneumonia diagnostic in the community care of rural Bangladeshi children (Aim 1) and to develop and validate a childhood respiratory illness severity score appropriate for community care in Asia (Aim 2). In Aim 1, Dr. McCollum will lead a team of lay community health workers (CHWs) in the enrollment of 1,500 rural Bangladeshi children sick with cough and/or difficulty breathing in order to assess whether a low oxygen saturation is associated with radiographic pneumonia. In Aim 2, Dr. McCollum will direct a team of CHWs to recruit 2,200 rural Bangladeshi children with World Health Organization-defined non-severe pneumonia in order to develop and validate a risk score predictive of oral antibiotic failure and appropriate for CHWs. The research described in this application will serve as the foundation for independent funding proposals for intervention trials using pulse oximetry in rural Asian community care programs as a diagnostic pneumonia tool and as a validated instrument to assess pneumonia severity.

描述（由申请人提供）：这是为约翰·霍普金斯大学 Eudowood 儿科呼吸科学部的儿科肺科医生 Eric D. McCollum 博士申请福格蒂国际中心 K01 国际研究科学家发展奖的提交材料。 McCollum 博士是资源匮乏国家儿童呼吸道疾病领域的一名初级临床研究员。该K01奖项将为McCollum博士提供实现以下目标所需的支持：（1）成为亚洲资源有限环境中临床研究实施和管理的专家； (2) 培养高级研究设计和生物统计方法的技能； (3) 与儿科肺科医生建立多学科、远距离的合作。为了实现这些目标，McCollum 博士组建了一个指导团队，其中包括美国首席导师、约翰·霍普金斯大学彭博公共卫生学院国际卫生系教授 Abdullah Baqui 博士，他是资源匮乏的亚洲地区儿童健康领域的国际领导者。国家，以及孟加拉国首席导师、约翰·霍普金斯大学彭博公共卫生学院国际卫生部助理科学家、孟加拉国儿童健康专家 Dipak Mitra 博士，以及四位共同导师；博士。 Katherine O'Brien 和 Bareng Aletta Sanny Nonyane 分别是儿童呼吸道流行病学和分析专家；和博士。帕梅拉·泽特林 (Pamela Zeitlin) 和威廉·切克利 (William Checkley) 都是肺病学专家。肺炎是全球和亚洲儿童死亡的第一大原因。 McCollum 博士的研究将利用正在进行的多中心肺炎球菌疫苗影响研究来评估脉搏血氧测定法作为孟加拉农村儿童社区护理中肺炎诊断的作用（目标 1），并开发和验证适合亚洲社区护理的儿童呼吸道疾病严重程度评分（目标 2）。在目标 1 中，McCollum 博士将带领一支非专业社区卫生工作者 (CHW) 团队招募 1,500 名患有咳嗽和/或呼吸困难的孟加拉国农村儿童，以评估低氧饱和度是否与放射学肺炎有关。在目标 2 中，McCollum 博士将指导社区卫生工作者团队招募 2,200 名患有世界卫生组织定义的非严重肺炎的孟加拉国农村儿童，以开发和验证适合社区卫生工作者的预测口服抗生素失败的风险评分。本申请中描述的研究将作为独立资助提案的基础，在亚洲农村社区护理项目中使用脉搏血氧仪作为诊断肺炎工具和评估肺炎严重程度的有效工具进行干预试验。