Mentoring Junior Investigators in Alcohol Research

指导酒精研究的初级研究者

• 批准号: 7918766
• 负责人: Joannes B Hoek
• 金额: $ 22.04万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-20 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7918766
• 关键词: Acute; Address; Alcohol consumption; Alcoholism; Alcohols; Apoptosis; Area; Award; Bioinformatics; Biomedical Engineering; Biotechnology; Cell Proliferation; Cellular biology; Chronic; Clinical; Computational Biology; Defect; Disease; Energy Metabolism; Funding; Generations; Goals; Human; Injury; Mentors; Mentorship; Metabolism; Molecular; National Institute on Alcohol Abuse and Alcoholism; Patients; Research; Research Personnel; Scientist; Senior Scientist; Signal Pathway; Signal Transduction; Staging; Tissues; Training; Wound Healing; alcohol effect; alcohol exposure; alcohol research; base; career; chronic alcohol ingestion; experience; insight; instructor; novel; problem drinker; professor; skills

DESCRIPTION (provided by applicant): The goal of this Senior Scientist Research and Mentorship award is to generate opportunities for the PI to provide mentoring in cellular and molecular aspects of alcohol research to junior investigators in the early stages of their research career (Instructor or Assistant Professor). The PI has a over twenty years of NIAAA funded research experience in the study of the interactions of acute and chronic alcohol exposure on cellular signaling pathways, energy metabolism, apoptosis and the associated tissue damage. He has mentored multiple scientists who have since established themselves as independent investigators in this field. The PI is now initiating new mentoring relationships with young investigators to stimulate the application of novel bioinformatics and computational approaches to analyze the cellular and molecular basis of alcohol-induced tissue defects. Specifically, this research addresses questions of how effects of ethanol on the cell signaling network can integrate with its effects on cell proliferation and tissue repair, metabolism and tissue injury. These findings will also be applied to tissues obtained from human alcoholic patients in order to extend insights into cellular interactions related to chronic alcohol use to the clinical context. The junior scientists selected for mentoring come with different and complementary areas of expertise ranging from molecular and cell biology, to biotechnology and bioengineering, and computational biology. They will apply the skills obtained in their prior training to related problems in alcohol research and bring new insight into fundamental questions related to diseases associated with alcohol use and alcoholism. It is expected that these mentoring relationships will help bring a new generation of scientists with highly relevant skills to the field of alcohol research.

描述（由申请人提供）：该高级科学家研究和指导奖的目标是为PI在其研究职业的早期阶段（讲师或助理教授）为初级研究人员提供饮酒研究的细胞和分子方面的指导。 PI在研究急性和慢性酒精暴露在细胞信号传导途径，能量代谢，凋亡和相关组织损伤上的相互作用方面拥有20多年的NIAAA资助研究经验。他指导了多位科学家，这些科学家此后就确立了这一领域的独立研究人员。 PI现在正在与年轻研究者启动新的指导关系，以刺激新型生物信息学和计算方法的应用，以分析酒精诱导的组织缺陷的细胞和分子基础。具体而言，该研究解决了乙醇对细胞信号网络的影响如何与细胞增殖和组织修复，代谢和组织损伤的影响相结合的问题。这些发现也将应用于从人类酒精患者那里获得的组织，以扩展到与慢性酒精使用相关的细胞相互作用到临床环境的洞察力。选择指导的初级科学家具有不同和互补的专业知识领域，从分子和细胞生物学，生物技术和生物工程以及计算生物学等等。他们将在先前培训中将获得的技能应用于酒精研究中的相关问题，并为与酒精使用和酒精中毒相关的疾病有关的基本问题提供新的见解。预计这些指导关系将有助于将具有高度相关技能的新一代科学家带入酒精研究领域。