EPIDEMIOLOGY OF CARDIAC DEVELOPMENT IN YOUTH

青少年心脏发育的流行病学

• 批准号: 2446543
• 负责人: DARWIN R. LABARTHE
• 金额: $ 7.36万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2446543
• 关键词: adolescence (12-20); anatomy; body composition; child (0-11); child physical development; epidemiology; gender difference; heart; heart function; human data; human puberty; longitudinal human study; racial /ethnic difference

DESCRIPTION (Adapted from the applicant's abstract) The goal of this research is to elucidate on the basis of a mixed longitudinal design the changes in cardiac structure and function which occur during late childhood and adolescence. Four aims are presented: 1) to document the nature and extent of changes in cardiac structure, based on M-mode measurements and indices and develop corresponding reference values; 2) to document the nature and extent of GENDER AND MINORITIES Of the 678 participants enrolled in Project HeartBeat!, 136 (20.1%) were African-American, 506 (74.6%) were Caucasian, 25 (3.7%) were Hispanic, 7 (1%) were Asian, and 4 (0.6%) were Native American. 333 (49.1%) were female and 345 (50.9%) were male. Completeness of follow-up by gender and ethnicity is not provided. 81.4% of the total study group attended all scheduled examinations, and 90.9% of subjects eligible for at least 10 examinations completed 10 or more exams. BUDGET Under Other Expenses in Year 1, the budget for "Publications, presentations, (graphics, page charges)" is reduced from $1000 to $250, since most of the costs incurred in this category will occur in Year 2. Two full years at the FTE proposed appears excessive for the work described, given the expertise of the team. It is recommended to reduce the funding period to 18 months, and therefore reduce the requested budget for Year 2 by one-half.

描述 （根据申请人的摘要改编）这项研究的目的是 根据混合纵向设计阐明心脏的变化 儿童晚期和青春期发生的结构和功能。 提出了四个目标：1）记录变化的性质和程度 心脏结构，基于M模式的测量和指数并发展 相应的参考值； 2）记录 性别和少数民族 在“ Heartbeat！”中注册的678名参与者中，有136（20.1％）为 非裔美国人，506（74.6％）为高加索人，25岁（3.7％）是西班牙裔，7 （1％）是亚洲人，4（0.6％）是美国原住民。 333（49.1％）是女性 和345（50.9％）是男性。 性别随访的完整性 没有提供种族。 总体研究组的81.4％参加了全部 预定考试，有90.9％的受试者有资格至少10个 考试完成了10次或更多考试。 预算 根据第1年的其他费用，“出版物，演讲， （图形，页面费用）“从$ 1000降低到$ 250，因为大多数 这一类别产生的成本将在2年内发生。 鉴于专业知识，提出的FTE对于所描述的工作似乎过多 团队。 建议将资金期限缩短到18个月， 因此，将第二年的要求预算降低了一半。