Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network

急性肺损伤的预防和早期治疗临床试验网络

• 批准号: 9063082
• 负责人: TODD W RICE
• 金额: $ 37.7万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-17 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9063082
• 关键词: Acute Lung Injury; Adult Respiratory Distress Syndrome; Affect; Biological; Clinical; Clinical Data; Clinical Trials; Clinical Trials Network; Collection; Data Analyses; Data Collection; Data Quality; Devices; Early treatment; Gender; Generations; Genetic; Genomics; Goals; Health; Hospitals; Leadership; Methods; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Patient Recruitments; Patient-Focused Outcomes; Pneumonia; Prevention; Procedures; Process; Proteomics; Protocols documentation; Publications; Recruitment Activity; Research Personnel; Sampling; Sepsis; Specimen; Structure; Techniques; Testing; Trauma; United States National Institutes of Health; Work; drug testing; improved; improved outcome; innovation; member; microbiome; mortality; novel; operation; prevent; protocol development

DESCRIPTION (provided by applicant): The objective of this proposal is to support the operation of the NIH NHLBI prevention and early treatment of acute lung injury (PETAL) Network> The Network's goal is to efficiently test drugs, devices, and protocols to prevent and treat early acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) thereby improving the short and long-term outcomes of patients. To achieve this goal the investigators will: 1. Provide organizational leadership to a Steering Committee and Subcommittees to establish an orderly, rational, process to develop, select, and conduct at least two clinical trials and to refine the Network's structure, and operating procedures. 2. Collaborate in the generation of hypotheses, development of protocols, and refinement of recruitment and data collection techniques and methods to acquire and analyze clinical data and samples. This effort will include collection of high quality biological and genetic specimens to allow Network members and others outside the network to study the genomics, proteomics and microbiome of acute lung injury. 3. Over 5.5 years recruit a minimum of 220, gender and ethnically representative subjects to clinical trials to generate quality data to test hypotheses posed by the Steering Committee. 4. Disseminate study results through high profile scientific publications and presentations.

描述（由申请人提供）：本提案的目的是支持 NIH NHLBI 急性肺损伤预防和早期治疗 (PETAL) 网络的运行> 该网络的目标是有效测试药物、设备和方案，以预防和治疗急性肺损伤。治疗早期急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS），从而改善患者的短期和长期预后。为了实现这一目标，研究人员将： 1. 为指导委员会和小组委员会提供组织领导，以建立有序、合理的流程来开发、选择和进行至少两项临床试验，并完善网络的结构和操作程序。 2. 协作提出假设、制定方案以及完善招募和数据收集技术和方法，以获取和分析临床数据和样本。这项工作将包括收集高质量的生物和遗传样本，以便网络成员和网络外的其他人能够研究急性肺损伤的基因组学、蛋白质组学和微生物组。 3. 在 5.5 年内招募至少 220 名具有性别和种族代表性的受试者参加临床试验，以生成高质量数据来检验指导委员会提出的假设。 4. 通过高调的科学出版物和演示传播研究结果。