PROSPECTIVE STUDY OF THE ONSET OF NICOTINE DEPENDENCE

尼古丁依赖发生的前瞻性研究

• 批准号: 2546985
• 负责人: JOSEPH R DIFRANZA
• 金额: $ 23.69万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2546985
• 关键词: adolescence (12-20); clinical research; dosage; drug abuse education; drug addiction; human subject; interview; longitudinal human study; nicotine; sign /symptom; smoking cessation; tobacco abuse

DESCRIPTION: (Applicant's Description) Little is known about the process by which nicotine dependence develops among adolescent tobacco users. This project will follow a cohort of 650 7th grade students over a period of three and one half years. These subjects will be interviewed every four months during this period about their experiences with tobacco. The tobacco use of these subjects will be monitored in detail with specific attention to the duration of use, the frequency of use and the amount of tobacco consumed. Subjects will be monitored for the development of symptoms of nicotine dependence. The following specific hypotheses will be addressed: 1) Symptoms of nicotine dependence can appear within two months of the first use of tobacco. 2) Symptoms of nicotine dependence can be present when consumption averages less than one cigarette per day. 3) Youths can develop symptoms of nicotine dependence prior to the onset of the daily use of tobacco. 4) The inability to refrain from smoking where it is prohibited will not be an early symptom of dependence.

描述：（申请人的描述） 关于尼古丁依赖的过程知之甚少 在青少年烟草用户中。 该项目将遵循650个队列 三年级的7年级学生三年半。 这些 在此期间，将每四个月对受试者进行一次面试 他们在烟草方面的经验。 这些主题的烟草使用将是 详细监控，特别注意使用时间的持续时间 使用频率和消耗的烟草量。 受试者将是 监控尼古丁依赖性症状的发展。 这 以下具体假设将得到解决：1）尼古丁的症状 依赖性可以在首次使用烟草的两个月内出现。 2） 消费平均时，尼古丁依赖的症状可能存在 每天不到一支香烟。 3）年轻人可以发展尼古丁的症状 在日常使用烟草开始之前的依赖性。 4）无能 避免禁止吸烟的地方不会是早期症状 依赖。