ASBMR Three Year Symposia

ASBMR 三年研讨会

基本信息

批准号：
9194598
负责人：
DOUGLAS P. KIEL
金额：
$ 4.3万
依托单位：
AMERICAN SOCIETY FOR BONE & MINERAL RES
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9194598
关键词：
Academia Accounting Address Affect American Animal Model Area Biological Markers Biomechanics Cartilage Cartilage Diseases Cells Clinical Clinical Research Complex Data Degenerative polyarthritis Disease Fracture Functional disorder Funding Genomics Goals Government Grant Human Image Incidence Industry Joints Laboratories Medical Societies Metabolism Methods Minerals Molecular Biology Morbidity - disease rate Musculoskeletal Diseases Osteoporosis Patient Care Patients Physiology Professional Organizations Recording of previous events Research Research Personnel Risk Scientific Societies Scientist Serum Skeleton Societies Structure Surrogate Markers Time Translating Translations Underrepresented Minority United States National Institutes of Health Woman base bone bone quality burden of illness clinical application cost improved in vivo joint destruction meetings men mortality precision medicine prevent skeletal skeletal disorder symposium

项目摘要

The American Society for Bone and Mineral Research (ASBMR), the largest professional, scientific and medical society established to bring together clinical and laboratory-based scientists who are involved in the study of bone and mineral metabolism, has had a successful history of conducting annual topical meetings funded by single year NIH R13 grants since 2002. This application seeks funding for a three year R13 grant to advance the field of skeletal diseases by focusing on three specific areas of scientific research: 1) skeletal genomics (“Bone-omics–Translating Genomic Discoveries into Clinical Applications”); 2) bone fragility (“Current Concepts in Bone Fragility: From Cells to Surrogates”); 3) skeletal contributions to the pathophysiology and clinical manifestations of osteoarthritis (“Skeletal Contributions to Joint Degeneration and Osteoarthritis”). These three areas cover a range of topics that collectively contribute to a majority of the clinical morbidity and mortality of skeletal disease. The overall objective of this R13 is to stimulate further advances that will result in improved patient care for skeletal diseases by bringing together the best researchers for each of the three symposia that will be held in conjunction with the annual meetings of the ASBMR. Each of the three symposia will review the state of the art in each topic area, exchanging ideas with attendees, and stimulating the interaction between young and established researchers. For each of the three symposia, attendees will be encouraged to attend the subsequent ASBMR Annual Meetings for additional opportunities to interact with bone researchers. Agendas for all three years have been developed by an organizing committee with committed speakers for the first two years. The agendas include established and young investigators, men, women and underrepresented minority speakers. At the end of each meeting, a “dine-around” evening is planned to allow direct interaction between young investigators and more senior speakers at the meeting. In 2016, the symposium will appraise the latest contributions of the field of genomics to the understanding of skeletal disease mechanisms, ranging from basic molecular biology to animal models and bidirectional translation to humans, particularly within the scope of precision medicine and targeted treatments. The 2017 symposium will discuss the latest research on the mechanisms underlying skeletal fragility and state-of-the-art methods to assess fracture risk. In addition, new data supporting the use of surrogate markers for fracture will be discussed. The 2018 symposium will promote interaction among basic, translational and clinical researchers in skeletal and osteoarthritis research, with a focus on recent data emerging on cartilage-bone structure and physiology within articulating joints.

美国骨与矿物质研究学会 (ASBMR)，最大的专业、科学和成立医学会的目的是将参与该领域的临床和实验室科学家聚集在一起研究骨和矿物质代谢，拥有举办年度专题会议的成功历史自 2002 年以来，由 NIH R13 单年度拨款资助。本申请寻求三年 R13 拨款的资助通过重点关注三个特定的科学研究领域来推进骨骼疾病领域的发展：1）骨骼基因组学（“骨组学——将基因组发现转化为临床应用”）；2）骨脆性（“骨脆性的当前概念：从细胞到替代品”）3）骨骼对骨脆性的贡献骨关节炎的病理生理学和临床表现（“骨骼对关节退化和退化的贡献”）骨关节炎”）这三个领域涵盖了一系列主题，共同构成了大部分主题。 R13 的总体目标是进一步刺激骨骼疾病的临床发病率和死亡率。通过汇集最好的技术进步，将改善骨骼疾病患者的护理将与年会同时举行的三个研讨会的研究人员 ASBMR。三个研讨会中的每一个都将回顾每个主题领域的最新技术，并与与会者，并刺激年轻和成熟研究人员之间的互动。研讨会，将鼓励与会者参加随后的 ASBMR 年会，以获取更多信息与骨骼研究人员互动的机会已由一个人制定了三年的议程。组织委员会在前两年有承诺的发言人议程包括既定的和年轻的调查员、男性、女性和代表性不足的少数族裔发言者。计划“就餐”之夜，让年轻研究人员和更资深的研究人员之间进行直接互动 2016年研讨会将评议基因组学领域的最新贡献。了解骨骼疾病机制，从基础分子生物学到动物模型以及向人类的双向翻译，特别是在精准医学和靶向治疗的范围内 2017年研讨会将讨论骨骼机制的最新研究。此外，新数据支持使用脆弱性和评估骨折风险的最先进方法。 2018 年研讨会将讨论骨折替代标志物之间的相互作用。骨骼和骨关节炎研究的转化和临床研究人员，重点关注最新数据新兴的关节软骨骨结构和生理学。