Administrative Supplements for the NCI P30 Cancer Center Support Grants for Multi-Channel Communication Campaigns for Improvements in Cancer Education and Outcomes (MICEO) in Underserved Populations

NCI P30 癌症中心行政补充，支持多渠道沟通活动，以改善服务不足人群的癌症教育和结果 (MICEO)

• 批准号: 10891877
• 负责人: Boris Pasche
• 金额: $ 20万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-01 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10891877
• 关键词: Academy; Adherence; Administrative Supplement; Area; Black race; Breast Cancer Detection; Businesses; COVID-19 pandemic; Cancer Center Support Grant; Cancer Control; Catchment Area; Censuses; Cities; Collaborations; Communication; Communities; Development; Diagnosis; Future; General Population; Goals; Health; Institution; Intervention; Knowledge; Malignant Neoplasms; Mammographic screening; Mammography; Marketing; Media Campaign; Medically Underserved Area; Michigan; Outcome; Population; Poverty; Risk; Screening for cancer; Social Network; Training; Underserved Population; United States Health Resources and Services Administration; Woman; Work; aged; black women; cancer education; cancer prevention; community building; improved; literacy; malignant breast neoplasm; member; metropolitan; mortality; pandemic disease; pre-pandemic; programs; psychoeducation; psychoeducational; screening; social media

Abstract The catchment area of Karmanos Cancer Institute (KCI) includes Southeast Michigan and the city of Detroit. According to the 2022 U.S. Census, 78% of Detroiters identify as Black, 32% live in poverty compared to 13% in the state of Michigan, and the majority of census tracts in the city of Detroit are medically underserved areas (MUAs) based on HRSA definitions. Engaging this population in cancer prevention and control efforts is essential. In the proposed work, we will address Track 2 with a focus on the General Population (30+ years) and breast cancer screening. Our preliminary work suggests some delay in mammography screening due to the COVID-19 pandemic, consistent with other work indicating missed or delayed cancer screenings in the first year of the pandemic 1 2 and lower than pre-pandemic screening levels in the second year 3, raising concerns about a future risk in late-stage diagnoses. This is especially concerning given the breast cancer mortality rates of 34.3 per 100,000 among Black women in Detroit compared to 21.3 per 100,00 among White women in the KCI catchment area. Breast cancer screening promotion is consistent with an emerging KCI OCHECE initiative: Karmanos Academy, a program with the primary goal of building community capacity for improving cancer prevention and control throughout the KCI catchment area. Through Karmanos Academy, community members will be trained as lay health advisors (LHAs) to deliver relevant interventions within local organizations and institutions as well as their own social networks. The proposed work has three aims: Aim 1: Adapt an existing LHA-led psychoeducational program to increase mammography adherence among Black women in the metropolitan Detroit area in collaboration with community stakeholders; Aim 2: Collaborate with existing KCI OCHECE community partners to enlist and train community members as LHAs who will deliver the adapted psychoeducational program; Aim 3: Partner with KCI's Marketing and Business Development Department to develop and implement a social media toolkit to promote mammography adherence among Black women in the metropolitan Detroit area. We will create a video-based adaptation of the Real Talk intervention to increase mammography adherence among Black women aged 40 years and older. This video will be an integral part of LHA-led sessions on this topic, session coordinated in tandem with a social media campaign. Ultimately, the proposed work will improve cancer literacy and breast cancer knowledge among Black women in metro Detroit through strategic use of multiple communication channels.

抽象的 Karmanos癌症研究所（KCI）的集水区包括密歇根州东南部和城市 底特律。根据2022年的美国人口普查，有78％的底特律人认为是黑人，有32％的人生活在贫困中 密歇根州的13％以及底特律市的大多数人口普查区是医学上的 基于HRSA定义的服务不足的区域（MUA）。使这一人群参与预防癌症和 控制工作至关重要。在拟议的工作中，我们将针对一般的曲目2讲话2 人口（30多年）和乳腺癌筛查。我们的初步工作表明有些延迟 乳房X线摄影筛查是由于COVID-19大流行而引起的，与其他表明错过或的工作一致 大流行1 2的第一年延迟癌症筛查，低于流行前筛查水平 在第3年，引起人们对晚期诊断未来风险的担忧。这尤其令人担忧 鉴于底特律的黑人妇女的乳腺癌死亡率为每100,000人34.3，而21.3 KCI集水区的白人妇女中的每100,00。乳腺癌筛查促进是一致的 采用新兴的KCI Ochece倡议：Karmanos Academy，一个计划的主要目标是建立 在整个KCI集水区中改善癌症预防和控制的社区能力。通过 Karmanos Academy，社区成员将接受外行健康顾问（LHA）的培训，以提供相关 本地组织和机构的干预措施以及自己的社交网络。提议 工作有三个目标：目标1：适应现有的LHA领导的心理教育计划以增加 底特律大都会区黑人妇女的乳房X线摄影遵守与与之合作 社区利益相关者； AIM 2：与现有的KCI Ochece社区合作伙伴合作以入伍和 将社区成员培训为LHA，将提供适应的心理教育计划；目标3：合作伙伴 KCI的营销和业务发展部开发和实施社交媒体工具包 为了促进底特律大都会地区黑人妇女的乳房摄影遵守。我们将创建一个 基于视频的真实谈话干预措施的改编以增加黑色的乳房X线摄影效果 40岁及以上的妇女。该视频将是LHA领导的此主题，会议的组成部分 与社交媒体运动协调。最终，拟议的工作将改善癌症 黑人妇女在底特律大都会的识字和乳腺癌知识通过战略性使用 沟通渠道。

项目成果

Synergistic Suppression of NF1 Malignant Peripheral Nerve Sheath Tumor Cell Growth in Culture and Orthotopic Xenografts by Combinational Treatment with Statin and Prodrug Farnesyltransferase Inhibitor PAMAM G4 Dendrimers.

• DOI: 10.3390/cancers16010089
• 发表时间: 2023-12-23
• 期刊: CANCERS
• 影响因子: 5.2
• 作者: Reiners Jr, John J.;Mathieu, Patricia A.;Gargano, Mary;George, Irene;Shen, Yimin;Callaghan, John F.;Borch, Richard F.;Mattingly, Raymond R.
• 通讯作者: Mattingly, Raymond R.

Imaging of Nanoparticle Distribution to Assess Treatments That Alter Delivery.

• DOI: 10.1007/s11307-017-1142-2
• 发表时间: 2018-06
• 期刊: Molecular imaging and biology
• 影响因子: 3.1
• 作者: Blocker SJ;Shields AF
• 通讯作者: Shields AF

Single-incision transaxillary robotic thyroidectomy: challenges and limitations in a North American population.

• DOI: 10.1177/0194599812461610
• 发表时间: 2012-12
• 期刊: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
• 作者: Lin HS;Folbe AJ;Carron MA;Zuliani GF;Chen W;Yoo GH;Mathog RH
• 通讯作者: Mathog RH

Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium.

• DOI: 10.1016/j.ejca.2012.01.038
• 发表时间: 2012-09
• 期刊: EUROPEAN JOURNAL OF CANCER
• 影响因子: 8.4
• 作者: Cote, Michele L.;Liu, Mei;Bonassi, Stefano;Neri, Monica;Schwartz, Ann G.;Christiani, David C.;Spitz, Margaret R.;Muscat, Joshua E.;Rennert, Gad;Aben, Katja K.;Andrew, Angeline S.;Bencko, Vladimir;Bickeboeller, Heike;Boffetta, Paolo;Brennan, Paul;Brenner, Hermann;Duell, Eric J.;Fabianova, Eleonora;Field, John K.;Foretova, Lenka;Friis, Soren;Harris, Curtis C.;Holcatova, Ivana;Hong, Yun-Chul;Isla, Dolores;Janout, Vladimir;Kiemeney, Lambertus A.;Kiyohara, Chikako;Lan, Qing;Lazarus, Philip;Lissowska, Jolanta;Le Marchand, Loic;Mates, Dana;Matsuo, Keitaro;Mayordomo, Jose I.;McLaughlin, John R.;Morgenstern, Hal;Mueeller, Heiko;Orlow, Irene;Park, Bernard J.;Pinchev, Mila;Raji, Olaide Y.;Rennert, Hedy S.;Rudnai, Peter;Seow, Adeline;Stucker, Isabelle;Szeszenia-Dabrowska, Neonila;Teare, M. Dawn;Tjonnelan, Anne;Ugolini, Donatella;van der Heijden, Henricus F. M.;Wichmann, Erich;Wiencke, John K.;Woll, Penella J.;Yang, Ping;Zaridze, David;Zhang, Zuo-Feng;Etzel, Carol J.;Hung, Rayjean J.
• 通讯作者: Hung, Rayjean J.

Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells.

• DOI: 10.3390/ijms22136676
• 发表时间: 2021-06-22
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Uddin MH;Li Y;Khan HY;Muqbil I;Aboukameel A;Sexton RE;Reddy S;Landesman Y;Kashyap T;Azmi AS;Heath EI
• 通讯作者: Heath EI