Precision Medicine for All of Us Researchers Collective Medicina de Precision: Colectivo de Investigadores Salud para Todos

为我们所有研究人员提供的精准医学 Collective Medicina de Precision: Colectivo de Investigadores Salud para Todos

• 批准号: 10891233
• 负责人: Jason Hansen Karnes
• 金额: $ 100.26万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10891233
• 关键词: Acceleration; Achievement; Address; All of Us Research Program; Area; Arizona; Automobile Driving; Awareness; Biomedical Research; Communities; Coupled; Data; Data Set; Decision Making; Dedications; Development; Ecosystem; Ensure; Equity; Funding; Generations; Grant; Hispanic-serving Institution; Incentives; Informatics; Institution; Investments; Mentors; Participant; Peer Review; Pharmacogenomics; Positioning Attribute; Publications; Recommendation; Research; Research Personnel; Research Project Grants; Resources; Training; Underrepresented Populations; Universities; Work; biomedical informatics; career; cloud based; community based participatory research; data standards; education resources; empowerment; experience; flexibility; health equity; innovation; interest; literacy; outreach; precision medicine; programs; recruit; research and development; scientific organization; success

Abstract The All of Us Research Program (AoU) has created a national research dataset unprecedented in size, diversity, and scope to advance precision medicine. However, data utilization is not yet commensurate with the power and potential impact, and researchers utilizing the dataset are not yet representative of communities historically underrepresented in biomedical research (UBR). The AoU's innovative cloud-based, centralized data governance requires broad professional development training for researchers, with a focus on informatics literacy and technical resources to support analysis within the AoU Researcher Workbench (AoURW). The University of Arizona (UArizona)-Banner AoU team will address this challenge through four Aims derived from our extensive experience leading interdisciplinary scientific teams to utilize AoURW and creating programs to engage researchers from UBR communities. Aim 1: Establish an AoU Data Fellows program to train and mentor researchers from UBR communities in leveraging the AoURW. Data Fellows will subsequently engage in outreach within their own networks to encourage AoUfocused research projects and awareness. Aim 2: Advance and manage a biomedical informatics core dedicated to equipping UBR and nontraditional researchers to conduct research in the AoURW. Aim 3: Incentivize AoURW research through high priority driver projects and seed grants with a focus on UBR and early-career investigators and health equity research. Aim 4: Form an Advisory Council (AC) to oversee Aims 1-3 and create partnerships with scientific organizations to engage researchers and scale initiatives nationally. Aims 1-4 will cultivate an active, diverse, and sustainable pool of AoU-focused researchers empowered by our resources and AoURW’s directive to advance precision medicine for the benefit of all communities. We will engage researchers from UBR communities to utilize the AoURW using active engagement strategies based on the principles of community based participatory research and research capacity building, while maintaining the flexibility to work with existing AoU partners and extend AoU resources. Our UArizona-Banner AoU team will assess the impact of our activities, disseminate promising practices to the broader scientific community, evaluate our initiatives against AoU programmatic objectives, and ensure that our researchers’ perspectives inform AoURW development—driving AoU further toward an inclusive ecosystem and an equitable platform.

抽象的 我们所有的研究计划（AOU）创建了一个空前的国家研究数据集 大小，多样性和范围，以促进精确医学。但是，数据利用尚未 与功能和潜在影响相称，使用数据集的研究人员不是 然而，在生物医学研究（UBR）中代表历史上代表人数不足。 AOU创新的基于云的集中数据治理需要广泛的专业 研究人员的发展培训，重点是信息素养和技术资源 支持AOU研究人员工作台（AOUR）中的分析。亚利桑那大学 （uarizona）-banner aou团队将通过我们的四个目标来应对这一挑战 丰富的经验领导跨学科科学团队利用Aourw并创建 与UBR社区的研究人员吸引的计划。 AIM 1：建立AOU数据研究员 从UBR社区培训和心理研究人员的计划，以利用AOURW。数据 研究员随后将在自己的网络中进行宣传，以鼓励以AOU为中心的研究项目和意识。目标2：提前和管理生物医学信息 致力于为UBR和非传统研究人员提供精力来进行研究的核心 aourw。目标3：通过高优先驾驶项目和种子激励AOURW研究 授予专注于UBR和早期研究人员和健康公平研究。目标4：形式 咨询委员会（AC）监督目标1-3并与科学建立伙伴关系 组织在全国范围内吸引研究人员和规模计划。目标1-4将培养 由我们的资源和 Aourw指令提高精确医学的所有社区利益。我们将 让来自UBR社区的研究人员使用积极参与来利用AOUR 基于社区参与研究和研究能力原理的策略 构建，同时保持与现有AOU合作伙伴合作并扩展AOU的灵活性 资源。我们的Uarizona-Banner Aou团队将评估我们的活动的影响，传播 对更广泛的科学界的有希望的实践，评估我们针对艾奥的举措 编程目标，并确保我们的研究人员的观点告知AOURW 开发 - 进一步驱动着包容性的生态系统和公平的平台。