ECOG-ACRIN Operations Center

ECOG-ACRIN 运营中心

基本信息

批准号：
9128208
负责人：
ROBERT L COMIS
金额：
$ 12.87万
依托单位：
ECOG-ACRIN MEDICAL RESEARCH FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-29 至 2019-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9128208
关键词：
Adult American College of Radiology Imaging Network Bioinformatics Biological Markers Biometry Cancer Biology Cancer Center Cancer Patient Caring Center for Translational Science Activities Clinical Clinical Data Clinical Informatics Clinical Research Clinical Trials Collaborations Communities Coupled Dana-Farber Cancer Institute Data Databases Development Diagnostic Diagnostic Imaging Discipline Early Diagnosis Eastern Cooperative Oncology Group Extramural Activities Fostering Funding Goals Image Information Technology Institute of Medicine (U.S.)Institution Intervention Investigation Joints Laboratories Leadership Malignant Neoplasms Minority Molecular Monitor National Cancer Institute National Clinical Trials Network Outcome Patient advocacy Patients Phase Population Positioning Attribute Public Health Rare Diseases Reporting Research Research Infrastructure Research Personnel Resources Risk Science Shapes Specialized Program of Research Excellence Specimen Subgroup System Tissues Translating Translational Research Translations Universities Validation Work advanced disease anticancer research base bench to bedside biobank cancer care cancer therapy cancer type career development clinical care clinical practice comparative effectiveness data management design effectiveness research experience imaging modality improved member multimodality named group operation programs response scientific organization standard of care treatment effect

项目摘要

DESCRIPTION (provided by applicant): Clinical trials continue to be a cornerstone to the effort to advance care and improve outcomes for cancer patients. ECOG and ACRIN collectively have over 65 years of experience conducting high impact clinical trials that have helped shaped clinical practice. In response to the National Clinical Trials Network (NCTN) initiative, ECOG and ACRIN have merged their complementary scientific programs to form the ECOG-ACRIN Cancer Research Group (E-A). We propose a program focused on the efficient development and implementation of practice-changing science along the cancer care continuum from early detection through treatment of advanced disease. We take advantage of combined expertise in imaging, cancer biology and therapy within our scientific organization, working closely with the biostatistics and data management center at the Dana Farber Cancer Institute and Brown University, to propose a portfolio of treatment and advance imaging trials that recognize the importance of biomarkers to identify appropriate patient subgroups for precisely targeted intervention. The E-A biorepositories, image database and associated translational science centers will leverage the data collected in the context of trials to perform correlative science studies that advance our understanding of cancer biology and treatment effect. We continue to seamlessly integrate with Cancer Center and SPORE research programs to create an interface for translating NCI-supported science into clinical trials and to attract junior investigators intothe NCTN. We propose to continue collaborating across the NCTN, contributing high quality trials, leadership in advance imaging, joint trial development and important NCTN operational infrastructure. E-A will leverage unique clinical informatics expertise to contribute a data warehouse of annotated images and specimens, laboratory analytics and clinical data to foster scientific discovery. E-A will contribute an accrual network of 37 main member institutions, 200 affiliates, 36 CCOPs and minority-based CCOPs that have accrued 33750 patients to clinical trials over the last 6 years. E-A is positioned to make unique contributions to the NCTN, working to translate NCI-supported science into improved outcomes for cancer patients. RELEVANCE: The primary goal of ECOG-ACRIN is to provide the support necessary to conduct relevant and rigorous clinical trials, which benefit public health by improving the quality and standard of care for cancer patients.

描述（由申请人提供）：临床试验仍然是推进癌症患者护理和改善治疗结果的基石。 ECOG 和 ACRIN 总共拥有超过 65 年的高影响力临床试验经验，帮助塑造了临床实践。为了响应国家临床试验网络 (NCTN) 倡议，ECOG 和 ACRIN 合并了其互补的科学项目，成立了 ECOG-ACRIN 癌症研究组 (E-A)。我们提出了一项计划，重点关注从早期检测到晚期疾病治疗的癌症护理连续体中有效开发和实施改变实践的科学。我们利用科学组织内成像、癌症生物学和治疗方面的综合专业知识，与达纳法伯癌症研究所和布朗大学的生物统计和数据管理中心密切合作，提出一系列治疗和先进的成像试验，以认可生物标志物对于识别适当的患者亚组以进行精确靶向干预的重要性。 E-A 生物样本库、图像数据库和相关转化科学中心将利用在试验中收集的数据进行相关科学研究，以增进我们对癌症生物学和治疗效果的理解。我们继续与癌症中心和 SPORE 研究项目无缝集成，创建一个接口，将 NCI 支持的科学转化为临床试验，并吸引初级研究人员加入 NCTN。我们建议继续在 NCTN 范围内进行合作，贡献高质量的试验、先进成像方面的领导地位、联合试验开发和重要的 NCTN 运营基础设施。 E-A 将利用独特的临床信息学专业知识来贡献带注释的图像和标本、实验室分析和临床数据的数据仓库，以促进科学发现。 E-A 将贡献一个由 37 个主要成员机构、200 个附属机构、36 个 CCOP 和少数族裔 CCOP 组成的累积网络，这些网络在过去 6 年里已经吸引了 33750 名患者参加临床试验。 E-A 致力于为 NCTN 做出独特贡献，致力于将 NCI 支持的科学转化为改善癌症患者的治疗结果。相关性：ECOG-ACRIN 的主要目标是提供进行相关且严格的临床试验所需的支持，通过提高质量来造福公众健康以及癌症患者的护理标准。