SEARCH: SMS Electronic Adolescent Reminders for Completion of HPV vaccination- Uganda

搜索：短信电子青少年提醒完成 HPV 疫苗接种 - 乌干达

基本信息

批准号：
10886152
负责人：
Sabrina Bakeera Kitaka
金额：
$ 26.63万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10886152
关键词：
Absenteeism Achievement Adolescent Adopted Africa Africa South of the Sahara African Authorization documentation Capital Caregivers Cellular Phone Child Childhood Cities Clinic Communities Country Development Diagnosis Disease Dose Education Effectiveness Electronics Eligibility Determination Enrollment Event Family Female Female Adolescents Foundations Fright Future Health Health care facility Household Human Papilloma Virus Vaccination Human Papilloma Virus Vaccine Human Papillomavirus Immunization Immunization Programs Income Intervention Interview Knowledge Language Leadership Malignant Neoplasms Malignant neoplasm of cervix uteri Measures Methods Nurses Outcome Paper Parents Pattern Perception Performance Phase Play Policy Maker Population Preventive measure Primary Prevention Process Publishing Randomized Randomized, Controlled Trials Research Role Schools Series Site System Target Populations Telephone Testing Text Messaging Time Translational Research Uganda Vaccinated Vaccination Vaccines Voice Woman World Bank adolescent health authority design feasibility trial girls implementation measures informant literacy low and middle-income countries member mortality outreach pilot trial preadolescence programs prototype public health relevance suburb usual care arm vaccine safety

项目摘要

Cervical cancer is the leading female cancer in Uganda. Many women are diagnosed with late-stage disease, and 80% of women die within 5 years of diagnosis, making primary prevention critical. HPV is the principal cause of cervical cancer, making vaccination the single most important primary preventive measure. The national HPV vaccination program in Uganda began in November 2015 and focuses solely on preteen/adolescent girls. Two strategies have been adopted for the multi-dose series: 1) school-based and 2) community-based. However, in Kampala, only 29% of girls receive both needed doses. Reasons for under vaccination include school absenteeism on special vaccination days for those receiving vaccination as part of a school program, failing to remember to come to a health facility for a needed dose for those being vaccinated in the community, and lack of knowledge regarding HPV and the vaccines including vaccine misperceptions. While research regarding the use of text message vaccine reminders is strong in the U.S., their use has not yet been demonstrated in a preteen/adolescent population in Sub-Saharan African or other low- and middleincome countries (LMICs). According to the World Bank, currently 89.9% of urban households in Uganda have a cell phone. This study will take place at three health centres and their affiliated schools and community immunization centers overseen by the Kampala Capital City Authority (KCCA) as well as at the Makerere/Mulago/Columbia Adolescent Health Clinic, also in Kampala. While text messages can be used in populations with low literacy, families can opt to receive automated phone call reminders instead. R21: Aim 1: Identify desired HPV vaccine text message reminder content (and parallel automated phone reminders) using key informant interviews We will conduct formative research using key informant interviews with stakeholders at each site as well as policy makers. Aim 2: Develop and pretest HPV vaccine reminders with target population We will share prototypes of the designed messages with families to identify issues with clarity, tone, and persuasiveness. Aim 3: Pilot assess the impact of vaccine reminders on HPV vaccination We will randomize caregivers of preteens/adolescents at one KCCA site and the adolescent clinic, stratified by site, language and HPV vaccine dose needed (initiation vs. completion). Feasibility milestones will include reach, effect size determination and implementation measures. R33: Aim 4: Conduct a full-scale randomized-control trial to assess the impact of text message reminders on HPV vaccination We will conduct a full-scale RCT assessing the impact of the HPV vaccine text message reminders. The main outcome will be timeliness of vaccination. We will also collect process/feasibility measures. This project, if successful, will provide an important foundation not only for the use of HPV vaccine text message reminders in Uganda but also for other childhood and adolescent vaccinations in Uganda and in other LMICs.

宫颈癌是乌干达主要的女性癌症。许多女性被诊断出患有晚期疾病，80% 的女性在诊断后 5 年内死亡，因此初级预防至关重要。 HPV 是宫颈癌的主要原因，因此疫苗接种成为最重要的主要预防措施。乌干达国家 HPV 疫苗接种计划于 2015 年 11 月开始，重点关注青春期前/青春期的女孩。多剂量系列采用了两种策略：1) 以学校为基础，2) 以社区为基础。然而，在坎帕拉，只有 29% 的女孩接受了两种所需的剂量。低于的原因疫苗接种包括在特殊疫苗接种日缺课的情况学校计划，没有记得去医疗机构为接种疫苗的人获取所需的剂量社区中缺乏有关 HPV 和疫苗的知识，包括对疫苗的误解。尽管美国对短信疫苗提醒的使用进行了大量研究，但其使用尚未得到广泛应用。尚未在撒哈拉以南非洲或其他低收入和中等收入国家 (LMIC) 的青春期前/青少年人群中得到证实。据世界银行统计，目前乌干达89.9%的城市家庭拥有一部手机。这项研究将在三个卫生中心及其附属学校和社区进行由坎帕拉首都管理局 (KCCA) 以及马凯雷雷/穆拉戈/哥伦比亚青少年健康诊所，也在坎帕拉。虽然短信可以用于对于识字率低的人群，家庭可以选择接收自动电话提醒。 R21：目标 1：识别所需的 HPV 疫苗短信提醒内容（以及并行的自动电话提醒）使用关键知情人访谈我们将使用关键知情人访谈进行形成性研究与每个地点的利益相关者以及政策制定者。目标 2：开发并预测试 HPV 疫苗提醒与目标人群我们将与家庭分享设计信息的原型，以识别问题清晰度、语气和说服力。目标3：试点评估疫苗提醒对HPV疫苗接种的影响将在一个 KCCA 站点和青少年诊所随机分配青春期前/青少年的护理人员，按站点分层，所需的语言和 HPV 疫苗剂量（开始与完成）。可行性里程碑将包括覆盖范围、效应大小的确定和实施措施。 R33：目标 4：进行全面随机对照评估短信提醒对 HPV 疫苗接种影响的试验我们将进行全面的随机对照试验评估 HPV 疫苗短信提醒的影响。主要成果将是及时性疫苗接种。我们还将收集流程/可行性措施。该项目如果成功，将提供不仅是乌干达使用HPV疫苗短信提醒的重要基础，也是其他国家使用HPV疫苗短信提醒的重要基础。乌干达和其他中低收入国家的儿童和青少年疫苗接种。