Brain mechanisms of reducing polysubstance use following a novel body-mind intervention

新型身心干预后减少多物质使用的大脑机制

• 批准号: 10836820
• 负责人: YIYUAN TANG
• 金额: $ 76.85万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10836820
• 关键词: Address; Alcohol consumption; Alcoholic Intoxication; Alcohols; Anterior; Brain; Cancer Etiology; Cannabis; Cannabis policy; Cause of Death; Cessation of life; Clinical; Corpus striatum structure; Drug usage; Electroencephalography; Goals; Link; Mind-Body Intervention; Outcome; Pharmaceutical Preparations; Prefrontal Cortex; Preventable cancer cause; Public Health; Reporting; Research; Self Assessment; Self-control as a personality trait; Testing; Tobacco; Tobacco use; addiction; cingulate cortex; college; craving; emerging adult; high risk; improved; marijuana use; mindfulness; mindfulness intervention; mindfulness meditation; neurofeedback; novel; polysubstance use; reduced alcohol use; university student

Tobacco use is the leading cause of cancer and the leading preventable cause of death. Alcohol use is responsible for ~88,000 deaths each year in the U.S. and is another primary preventable cause of cancer. The changing cannabis policies and the 8% increase in cannabis use in the last decade have brought new challenges for existing treatment efforts. Our recent studies among TTU college students indicate that over 50% of those who reported alcohol intoxication, tobacco use, or cannabis use in the past month were involved in two or more of these substances (alcohol, tobacco and cannabis - ATC). Growing evidence has shown that polysubstance use is associated with numerous and deleterious consequences for college-attending emerging adults, but they are often unmotivated to quit or reduce drug use. Therefore, there is an urgent need to address this critical public health issue of widespread polysubstance use in high risk college students. Despite multiple treatment efforts, outcomes are far from optimal since treatments often fail to capitalize on important target domains linked to addiction outcomes. Research shows that one target domain (mechanism) for ATC involves deficits in self-control networks including the prefrontal cortex (PFC), the anterior cingulate cortex (ACC), and the ACC-Striatum circuit. Based on previous research conducted by our team and others, self-control deficits have been linked to SUDs, and could be ameliorated through mindfulness meditation (MM) and/or EEG neurofeedback (NF), both of which target self-control networks and have the potential to minimize negative outcomes resulting from deficits in self-control. Although MM has shown promises in improving self- control and reducing ATC use, many struggle to engage in the mindfulness practice early in treatment. Promisingly, recent studies suggest that combining NF with MM may improve engagement with mindfulness practice and produce larger reductions in ATC use compared to MM alone. The goal of this project is to understand brain mechanisms of ATC reduction following brief IBMT, and optimize IBMT through EEG Neurofeedback (NF). We will assess self-control deficits and ATC use and examine the effects of IBMT and/or NF on improving self- control and reducing ATC use among TTU college students. Our study will be the first to reveal the brain mechanisms of combining mindfulness intervention and EEG neurofeedback for treating polysubstance use, and potentially provide preliminary evidence that the modulated self-control networks by IBMT+NF are associated with clinical benefits such as craving and ATC reduction in high risk college students.

烟草使用是癌症的主要原因，也是可预防的死亡原因。饮酒是 在美国，每年造成约88,000人死亡，是癌症的另一个主要可预防原因。这 在过去的十年中，改变大麻政策和大麻使用的8％增加了新的带来了新的 现有治疗工作的挑战。我们最近对TTU大学生的研究表明 在过去一个月中报告酒精中毒，烟草使用或大麻使用的人中有50％涉及 在两个或多个物质中（酒精，烟草和大麻-ATC）。越来越多的证据表明 Polysubstance使用与大学培训有关 成年人，但通常没有动力退出或减少吸毒。因此，迫切需要解决 这个关键的公共卫生问题在高风险的大学生中广泛使用多核心。尽管多个 治疗工作，结果远非最佳，因为治疗通常无法利用重要目标 与成瘾结果相关的域。研究表明，ATC的一个目标域（机制）涉及 自我控制网络的缺陷，包括前额叶皮层（PFC），前扣带回皮层（ACC）和 ACC纹状体电路。根据我们的团队和其他人进行的先前研究，自我控制缺陷 已经与泡沫有关，可以通过正念冥想（MM）和/或EEG来改善 神经反馈（NF），两者都靶向自我控制网络，并有可能最大程度地减少负面 自我控制缺陷导致的结果。尽管MM在改善自我控制方面表现出了承诺 并减少了ATC的使用，许多人在早期治疗中努力从事正念练习。有希望的， 最近的研究表明，将NF与MM结合可能会改善与正念实践和 与仅MM相比，ATC使用的减少较大。该项目的目的是了解大脑 简短IBMT之后，ATC降低的机制，并通过EEG Neurofeact（NF）优化IBMT。我们 将评估自我控制缺陷和ATC使用，并检查IBMT和/或NF对改善自我的影响 TTU大学生中的控制和减少ATC使用。我们的研究将是第一个揭示大脑的研究 结合正念干预和脑电神经反馈的机制，用于治疗多义的使用， 并有可能提供初步证据，表明IBMT+NF调制的自我控制网络是 与高风险大学生的渴望和ATC减少等临床益处相关。