The impact of long-term marijuana use on the neurocognitive functioning of individuals living with HIV

长期吸食大麻对艾滋病毒感染者神经认知功能的影响

基本信息

批准号：
8924276
负责人：
Chukwuemeka Nkemakonam Okafor
金额：
$ 3.79万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8924276
关键词：
AIDS/HIV problem Acquired Immunodeficiency Syndrome Activities of Daily Living Address Adherence Adverse effects Affect Alcohol or Other Drugs use Alcohols Brain Clinical Cohort Studies Cross-Sectional Studies Data Data Analyses Data Set Databases Development Disease Drug usage Etiology Fellowship Future General Population Goals Grant HIV HIV Infections HIV-associated neurocognitive disorder Healthcare High Prevalence Illicit Drugs Individual Lead Learning Life Long-Term Effects Longitudinal Studies Marijuana Measurement Measures Medical Memory Mentors Modeling Motor National Research Service Awards Nature Neurocognition Neurocognitive Neurocognitive Deficit Outcome Participant Pattern Performance Persons Policies Population Positioning Attribute Prevention strategy Prospective Studies Research Research Personnel Research Training Risk Sample Size Speed Statistical Models Substance abuse problem Symptoms Testing Time Tobacco Training Treatment outcome United States Viral Load result Woman Work base career cognitive performance cohort depressive symptoms design disease classification drug of abuse executive function experience information processing marijuana use medication compliance men men who have sex with men neuroAIDS neurobehavioral neuropsychological policy implication post-doctoral training pre-doctoral public health relevance responsible research conduct seropositive skills

项目摘要

DESCRIPTION (provided by applicant): The overall goal of the proposed project is to determine the impact of long-term marijuana use on the neurocognitive functioning of individuals living HIV/AIDS. Marijuana use is common among individuals living with HIV/AIDS in part due to its medical use for the management of HIV-related symptoms. However, a growing body of research in the general population suggests that marijuana use can alter normal brain functioning and lead to neurocognitive impairment. Individuals living with HIV/AIDS who use marijuana may experience additional burden of neurocognitive impairment due to their vulnerability to HIV-associated neurocognitive disorders, which affect approximately 50% of this population. Despite the increased use of marijuana in this population and the potential for adverse interactive effects on neurocognitive functioning very little is known about the nature and extent of long-term marijuana use on neurocognition in HIV, as methodological problems including use of cross-sectional designs, small sample sizes and lack of sufficient control for other substances of use (e.g. alcohol, tobacco and other illicit substances) have limited previous work. Therefore, this proposal seeks to determine whether long-term heavy marijuana use and HIV disease confers adverse effects on the neurocognitive functioning of individuals living with HIV/AIDS. The Multicenter AIDS Cohort Study (MACS) - an ongoing prospective study with data available for 2,202 HIV-seropositive and seronegative men has tracked cognitive performance and marijuana use for over 26 years and therefore provides an ideal dataset to address this question. The specific aims of this project are to conduct secondary data analysis of the MACS to: 1) determine the dynamic patterns of marijuana use and identify factors associated with these unique patterns and 2) investigate whether long-term heavy marijuana confers significant changes in neuropsychological performance in tasks of learning/memory, speed of information processing and executive functioning. Group based trajectory analysis and linear mixed effects modeling will be used. The research proposed in this application have profound clinical implications regarding the use of marijuana in individuals living with HIV/AIDS and can inform future neuroAIDS research in this relatively understudied topic. In addition, this F31 grant will provide the applicant with mentored training in: 1) etiology, nosology, and consequences of substance use and use disorders and their measurement, 2) the neurocognitive consequences of substance use and HIV, 3) analyzing longitudinal data and advanced statistical modelling, 4) development of professional and career skills, 5) responsible conduct of research. Upon completion of this F31 training fellowship the applicant will have acquired the necessary skill to place him in a well-poised position to apply and attain an Post-doctoral training fellowship that allow the applicant to expand his training and research skill related to substance abuse and HIV

描述（由申请人提供）：拟议项目的总体目标是确定长期吸食大麻对艾滋病毒/艾滋病患者神经认知功能的影响，部分原因是吸食大麻在艾滋病毒/艾滋病患者中很常见。然而，越来越多的针对普通人群的研究表明，吸食大麻会改变正常的大脑功能，并导致吸食大麻的艾滋病毒/艾滋病患者可能出现神经认知障碍。的额外负担由于易受 HIV 相关神经认知障碍影响而导致神经认知障碍，该群体约 50% 的人吸食大麻，并且可能对神经认知功能产生不利的相互作用，但人们对其性质和程度知之甚少。长期使用大麻对艾滋病毒神经认知的影响，因为方法学问题，包括使用横截面设计、小样本量以及对其他使用物质（例如酒精、烟草和其他非法物质）缺乏足够的控制，限制了以前的工作。因此，该提案旨在确定长期大量使用大麻和艾滋病毒疾病是否会对艾滋病毒/艾滋病患者的神经认知功能产生不利影响。多中心艾滋病队列研究 (MACS)——一项正在进行的前瞻性研究，涉及 2,202 名患者。 HIV 血清阳性和血清阴性男性对认知表现和大麻使用情况进行了超过 26 年的跟踪，因此提供了解决该问题的理想数据集。该项目的具体目标是对 MACS 进行二次数据分析，以： 1) 确定大麻使用的动态模式并确定与这些独特模式相关的因素，2) 研究长期大量吸食大麻是否会导致学习/记忆任务、信息处理速度和基于群体的执行功能的神经心理表现发生显着变化。将使用轨迹分析和线性混合效应模型。本申请中提出的研究对于艾滋病毒/艾滋病患者使用大麻具有深远的临床意义，并且可以为这一相对较少研究的主题的未来神经艾滋病研究提供信息。补助金将为申请人提供接受以下方面的指导培训：1) 物质使用和使用障碍的病因学、疾病学和后果及其测量，2) 物质使用和艾滋病毒的神经认知后果，3) 分析纵向数据和高级统计模型，4) 发展专业和职业技能，5) 负责任地进行研究。完成 F31 培训奖学金后，申请人将获得必要的技能，使他能够做好申请和获得博士后培训奖学金的准备，从而使申请人能够扩展业务。他的与药物滥用和艾滋病毒相关的培训和研究技能