Developmental Core

发展核心

• 批准号: 10598775
• 负责人: John T West
• 金额: $ 7.1万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598775
• 关键词: AIDS related cancer; Academic Training; Address; Affect; Africa; Africa South of the Sahara; African; Area; Authorship; Autopsy; Basic Science; Bioinformatics; Biological Markers; Biomedical Research; Biometry; Cancer Center; Cancer Research Infrastructure; Caring; Clinical; Clinical Medicine; Clinical Sciences; Collaborations; Communicable Diseases; Country; Coupled; Database Management Systems; Databases; Development; Diagnosis; Diagnostic; Disease; Educational workshop; Etiology; Faculty; Fostering; Funding; Genetic; Goals; HIV; HIV-1; HIV/AIDS; Health; Health Sciences; Histopathology; Hospitals; Human Herpesvirus 8; Human Resources; Immunologics; Immunology; Incentives; Incidence; Institution; Internet; Kaposi Sarcoma; Louisiana; Malignant Neoplasms; Medical; Mentors; National Institute of General Medical Sciences; Oceans; Oncology; Outcome; Persons; Pilot Projects; Prevention; Productivity; Program Development; Program Research Project Grants; Public Health; Public Health Schools; Research; Research Activity; Research Institute; Research Personnel; Research Support; Research Training; Resources; Tanzania; Targeted Research; Teaching Hospitals; Tissues; Training; Training Activity; Training Programs; United States; Universities; Viral; Viral reservoir; Virus Latency; Zambia; anticancer research; antiretroviral therapy; career; career development; comparative; design; experience; global health; implementation science; improved; inter-institutional; interest; leadership development; low and middle-income countries; metabolomics; neoplastic; next generation; peer; peer coaching; peer networks; programs; radiological imaging; research and development; skill acquisition; skills; success; training opportunity; virus related cancer

ABSTRACT Human resource capacity building and training are urgently needed to establish a sustainable research enterprise that will improve prevention, diagnosis, connection to care, basic mechanistic understanding, and treatment of neoplastic diseases, like Kaposi sarcoma (KS) that continue to affect people living with HIV (PLWH), despite effective antiretroviral therapy (ART). The combined expertise of our team, coupled with our ongoing D43 cancer research and training programs with CDH/UTH and ORCI, will bolster the continued development of CDH/UTH and ORCI research on KS and other HIV associated malignancies, while promoting inter-African research networking. It will also provide opportunities for U.S. oncology, infectious disease, and public health fellows interested in a research career in global health to gain essential experience in the LMIC setting and develop research collaborations. To further enhance cancer research infrastructure in Tanzania and Zambia, and specifically focus on KS, the “KS in the Era of ART in Africa Program (KEAAP)” proposes to establish a network comprised of LSUHSC-NO, CDH/UTH, and ORCI that is focused on implementation science, immunology, and histopathology of KS in PLWH. The goal of the Career Developmental Core is to provide mentoring and training activities that will support the research, career, and leadership development of promising investigators at ORCI and CDH/UTH as well as early-career clinical researchers from the United States. This goal will be achieved by 1) implementing a mentored pilot research project program to support scientifically meritorious projects led by junior investigators in Tanzania, Zambia, and the United States; 2) expanding peer-to-peer mentoring and career development programs between CDH/UTH, ORCI, and LSUHSC-NO; and 3) providing in-country courses, workshops, and cross-training between UTH and ORCI, focused on targeted research skills and professional development needs of early-stage investigators. Through these research and capacity building activities, KEAAP will foster an integrated mentoring approach, utilizing faculty from all involved institutions to serve as a resource for consortium trainees. KEAAP will encourage peer-peer networking among researchers through in-person and web-hosted training. KEAAP will develop a next-generation of researchers, mentors, and trainers who are anticipated to collaborate in, develop and cross- pollinate other’s research and training efforts that promote the development of increasingly more effective research networks for Sub-Saharan Africa/US collaborations focused on improving health outcomes for PLWH.

抽象的 迫切需要建立人力资源能力建设和培训以建立可持续的研究 将改善预防，诊断，与护理的联系，基本机理理解和 肿瘤疾病的治疗，例如Kaposi肉瘤（KS），继续影响HIV患者 （PLWH），尽管有效的抗逆转录病毒疗法（ART）。我们团队的联合专家，加上我们的 与CDH/UTH和ORCI一起正在进行的D43癌症研究和培训计划将加强持续的 开发有关KS和其他HIV相关的恶性肿瘤的CDH/UTH和ORCI研究，同时促进 非洲间研究网络。它还将为美国肿瘤学，传染病和 对全球健康研究生涯感兴趣的公共卫生研究员，以获得LMIC的基本经验 设置和开发研究合作。进一步增强坦桑尼亚的癌症研究基础设施 赞比亚，特别是专注于KS，“非洲艺术时代的KS（KEAAP）”提案 建立一个专注于实施的网络完成LSUHSC-NO，CDH/UTH和ORCI PLWH中KS的科学，免疫学和组织病理学。职业发展核心的目标是 提供心理和培训活动，以支持研究，职业和领导力发展 ORCI和CDH/UTH的有前途的研究人员以及联合的早期职业临床研究人员 国家。该目标将通过1）实施心理的试点研究项目来支持 由坦桑尼亚，赞比亚和美国的初级调查人员领导的科学功能性项目； 2） 在CDH/UTH，ORCI和 lsuhsc-no; 3）在UTH和ORCI之间提供国内课程，讲习班和交叉培训， 专注于有针对性的研究技能和早期研究人员的专业发展需求。通过 这些研究和能力建设活动，KEAAP将促进一种综合的心理方法，并利用 来自所有相关机构的教职员工作为财团学员的资源。 KEAAP会鼓励 通过面对面和网络主持的培训之间的研究人员之间的对等点网络。 KEAAP将发展 预计将在 授粉他人的研究和培训工作，以促进越来越有效的发展 撒哈拉以南非洲/美国合作的研究网络着重于改善PLWH的健康状况。