Botswana-UPenn: Research Consortium of HPV-Related Cervical Cancer in HIV Patient

博茨瓦纳-宾夕法尼亚大学：HIV 患者 HPV 相关宫颈癌研究联盟

• 批准号: 10834480
• 负责人: ERLE S. ROBERTSON
• 金额: $ 6.93万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10834480
• 关键词: Acquired Immunodeficiency Syndrome; Botswana; Cancer Burden; Cells; Cervical; Cervix carcinoma; Communicable Diseases; Development; Genetic Transcription; Goals; HIV; HIV Seronegativity; HIV Seropositivity; High Risk Woman; High-Throughput Nucleotide Sequencing; Human; Human Papillomavirus; Incidence; Infectious Agent; Inflammatory Response; Link; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Merkel Cells; Merkel cell carcinoma; Microarray Analysis; Monitor; Natural History; Nucleic Acids; Oncogenic; Pathogenesis; Patients; Polyomavirus; Population; Prevention; Process; Recovery; Research; Technology; Tissues; Validation; Woman; cohort; combinatorial; high risk; improved; low and middle-income countries; response

Abstract: The cervical cancer burden in low and middle income countries make up about 80% of the total cervical cancer incidence worldwide. In Botswana the link between increased incidences of cervical cancer in HIV positive women has not been carefully explored. Furthermore there is an increased link between infectious disease and cancer as seen by additional recent studies including the presence of Merkel Cell Carcinomas with Merkel Cell Polyoma virus. This underscores the importance of these agents and their contributions to the oncogenic process. Greater than 20% of human cancers are associated with infectious agents and that estimate is likely to be lower than the actual number. The advances in technology and approaches which include recovery of nucleic acids from tissues and other materials has greatly improved our ability to detect and confirm the identifications of these agents in associated cancers. The overall goal of the proposed studies in project #1 is to determine the contributions of infectious agents to development of cervical carcinomas in HIV positive women in Botswana. This dramatic increase in cervical cancer incidence in HIV positive women in Botswana allows for the potential contributions of additional agents as well as the inflammatory response which together leads to a more rapid and proliferative response. Our project will take advantage of our unique cohorts of women in Bostwana that allows us to monitor changes in the cervical flora from HPV and HIV negative women to women with cervical cancer who are HIV and HPV positive. Our initial question will be to identify additional agents which may be linked to development of cervical carcinomas in this population. Our working hypothesis is that multiple agents can contribute to the development of cervical carcinomas in HIV positive women in Botswana and this can result in an inflammatory response which synergistically leads to cervical carcinomas. We will utilize our newly developed combinatorial strategy which bridges microarray technology with high throughput sequencing. The identification of these agents will be followed by validation of the presence of these agents in tissues, transcription analysis of infected cells as well as analysis of the innate and adaptive inflammatory responses with the associated agents, and investigating the proliferative effects on these cells.

抽象的： 低收入国家和中等收入国家的宫颈癌负担约占总宫颈的80％ 全球癌症发病率。在博茨瓦纳，宫颈癌增加的联系 尚未仔细探索艾滋病毒阳性女性。此外，之间还有增加的联系 最近的其他研究（包括默克尔细胞的存在）可以看出传染病和癌症 带有默克尔细胞多瘤病毒的癌。这强调了这些代理商及其的重要性 对致癌过程的贡献。超过20％的人类癌症与 传染剂和该估计可能低于实际数量。进步 技术和方法，包括从组织和其他材料中恢复核酸的技术和方法 大大提高了我们检测和确认相关癌症对这些药物的识别的能力。 项目＃1中拟议研究的总体目标是确定传染剂的贡献 在博茨瓦纳的艾滋病毒阳性妇女中的宫颈癌发展。这种急剧增加 博茨瓦纳艾滋病毒阳性妇女的宫颈癌发病率可以做出潜在的贡献 其他药物以及炎症反应，共同导致更快， 增殖反应。我们的项目将利用我们在波斯特瓦纳的独特妇女队列的优势 允许我们监视从HPV和HIV负面女性到患有宫颈菌群的变化 HIV和HPV阳性的宫颈癌。我们最初的问题是确定其他代理商 这可能与该人群中宫颈癌的发展有关。我们的工作假设是 多种代理可以为艾滋病毒阳性女性的宫颈癌的发展做出贡献 博茨瓦纳（Botswana），这可能导致炎症反应，从而协同导致宫颈 癌。我们将利用新开发的组合策略，桥接微阵列 具有高吞吐量测序的技术。这些代理人的识别将随后 验证这些药物在组织中的存在，感染细胞的转录分析以及 分析与相关药物的先天和适应性炎症反应，并研究 对这些细胞的增殖作用。

项目成果

Patient Factors Associated With Delays in Obtaining Cancer Care in Botswana.

• DOI: 10.1200/jgo.18.00088
• 发表时间: 2018-08
• 期刊: Journal of global oncology
• 作者: Bhatia RK;Rayne S;Rate W;Bakwenabatsile L;Monare B;Anakwenze C;Dhillon P;Narasimhamurthy M;Dryden-Peterson S;Grover S
• 通讯作者: Grover S

Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship.

• DOI: 10.1200/jgo.2016.006585
• 发表时间: 2018-09
• 期刊: Journal of global oncology
• 作者: Grover S;Martei YM;Puri P;Prabhakar P;Mutebi M;Balogun OD;Price AJ;Freeman AH;Narasimhamurthy M;Rodin D;Rayne S;Zetola NM
• 通讯作者: Zetola NM

Cervical cancer control in HIV-infected women: Past, present and future.

• DOI: 10.1016/j.gore.2017.07.009
• 发表时间: 2017-08
• 期刊: Gynecologic oncology reports
• 影响因子: 1.2
• 作者: Ghebre RG;Grover S;Xu MJ;Chuang LT;Simonds H
• 通讯作者: Simonds H

Norms and beliefs related to cervical cancer screening amongst women aged 25-49 in Botswana: A pilot study.

博茨瓦纳 25-49 岁女性宫颈癌筛查相关规范和信念：一项试点研究。

• DOI: 10.1016/j.ijans.2018.11.001
• 发表时间: 2018
• 期刊: International journal of Africa nursing sciences
• 作者: Major,Thenjiwe;Koyabe,Bramell;Ntsayagae,Esther;Monare,Barati;Molwane,Olefile;Gabaitiri,Lesego
• 通讯作者: Gabaitiri,Lesego

Organ-Specific Toxicities Due to Radiation Therapy in Cancer Patients With or Without HIV Infection: A Systematic Review of the Literature.

有或没有 HIV 感染的癌症患者因放射治疗而产生的器官特异性毒性：文献的系统回顾。

• DOI: 10.3389/fonc.2018.00276
• 发表时间: 2018
• 期刊: Frontiers in oncology
• 影响因子: 4.7
• 作者: Xu,MelodyJ;Liewen,Alison;Valle,Luca;Olson,AdamC;Zetola,NicolaM;Grover,Surbhi
• 通讯作者: Grover,Surbhi