Project 2: Heat Waves during Pregnancy, Neurodevelopment, and Resiliency

项目 2：怀孕期间的热浪、神经发育和恢复能力

• 批准号: 10835397
• 负责人: Melissa Furlong
• 金额: $ 80.18万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-22 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10835397
• 关键词: Acceleration; Adopted; Animal Model; Apgar Score; Arizona; Attention deficit hyperactivity disorder; Birth; Birth Certificates; Cell model; Censuses; Childhood; Cities; Climate; Communication; Communities; Cross-Sectional Studies; Data; Data Sources; Disparate; Event; First Pregnancy Trimester; Future; Green space; Head; Health; Health protection; Heat Stress Disorders; Heat Waves; Housing; Human; Infant Health; Investigation; Knowledge; Lethargies; Link; Literature; Medicaid; Mission; Municipalities; Mus; Nature; Nervous System Physiology; Nervous System Trauma; Outcome; Oxidative Stress; Placentation; Policies; Population; Pregnancy; Pregnant Women; Premature Birth; Public Health; Publishing; Recording of previous events; Research; Research Personnel; Research Project Grants; Resolution; Resources; Risk; Route; Source; Symptoms; System; Temperature; Trees; Universities; Vulnerable Populations; Work; built environment; climate change; climate-related health; community engagement; dashboard; data integration; data visualization; exhaustion; experience; extreme weather; health data; member; neurodevelopment; novel; population based; pregnant; prospective; public health relevance; resilience; resilience factor; response; timeline

PROJECT ABSTRACT – Component: Research Project 2 As heatwaves and extreme weather events increase, populations in arid lands and urban heat-promoting landscapes may be at increased risk for heat-related illnesses. Although recent evidence suggests a strong association between heatwaves during pregnancy with preterm births and birth outcomes, the downstream effects on childhood neurodevelopment remain unexplored. Animal and cellular models show that temperature has profound effects on systems that regulate neurological functioning. Cross-sectional studies suggest heat stress induces lethargy and exhaustion, and may worsen symptoms of attention deficit hyperactivity disorder (ADHD). Prospectively, simulated heatwaves in pregnant mice induce neurological damage and oxidative stress, alter placental development, and diminish head size. In human studies, and in our pilot data of >700,000 births in Arizona, heatwaves during pregnancy are associated with lower Apgar score, which is a metric of health at birth and associated with later neurological functioning (including ADHD). However, despite this evidence, investigations of heatwaves and later neurodevelopment remain absent from the literature. Thus, in alignment with the mission of the Southwest Center on Resilience for Climate Change and Health (SCORCH), we propose to leverage the unique resources at the University of Arizona and use three decades of extant, population-based Medicaid and birth certificates data to investigate associations of temperature exposures during pregnancy on infant health and childhood neurodevelopment (Apgar score and ADHD) over three decades (1992-2022) in the state of Arizona. We will adopt a research-to-action framework and work with our Community Engagement Core to communicate findings on heat, neurodevelopment, and infant health, to community groups, public health agencies, and municipalities. Due to the urgent nature of climate change response, we additionally recognize the critical importance of promoting climate change resiliency by evaluating whether the built environment and policy may modify these climate-health relationships. Co-I Dr. Ladd Keith has consolidated municipal policy into a heat resiliency scorecard at the census-tract level, called the Plan Integration for Resiliency Scorecard (PIRS) for Heat, which is publicly available in select cities. Several other climate resiliency factors (e.g., transit routes, cooling centers, tree canopy, housing type) are potentially important modifiers of heat and health, although these data exist in disparate sources, at different timelines, and disparate resolutions. Together with the Integrated Data Visualization Core (IDVC), we will consolidate, link to health outcomes, and publish this data that will span multiple decades with >1million observations. This will facilitate broad data usage and accelerate critical research by other investigators on how climate change mitigation and the built environment promote climate resiliency. This proposal will additionally serve as a showcase for SCORCH-supported analyses that integrate protected health data with public data that will be available via online dashboards built by the Integrated Data Visualization Core.

项目摘要 - 组件：研究项目2 随着热浪和极端天气事件的增加，干旱土地和城市热量促进的人口 景观可能会增加与热有关的疾病的风险。尽管最近的证据表明有很强的 怀孕期间热浪与早产和出生结果之间的关联，下游 对儿童神经发育的影响仍然是出乎意料的。动物和细胞模型表明温度 对调节神经功能的系统具有深远的影响。横断面研究表明热量 压力会引起嗜睡和疲惫，并且可能会导致注意力缺陷多动障碍的症状更严重 （多动症）。前瞻性地，怀孕小鼠的模拟热浪诱导神经损害和氧化 压力，改变斑点发育并减小头部尺寸。在人类研究以及我们的试点数据中 在亚利桑那州> 700,000个出生，怀孕期间的热浪与较低的Apgar评分有关，这是一个 出生时健康度量指标，并与后来的神经功能功能（包括ADHD）相关。但是，多皮 文献中，对热浪和后来的神经发育的研究仍然没有。 这与西南地区对气候变化和健康的韧性中心的任务保持一致 （Scorch），我们建议利用亚利桑那大学的独特资源，并使用三十年 额外的，基于人口的医疗补助和出生证明数据以调查温度关联 怀孕期间对婴儿健康和儿童期神经发育（APGAR评分和多动症）的暴露 亚利桑那州的三十年（1992 - 2022年）。我们将采用研究框架，并与 我们的社区参与核心将有关热，神经发育和婴儿健康的发现传达给 社区团体，公共卫生机构和市政当局。由于气候变化的紧急性质 回应，我们还认识到通过 评估建筑环境和政策是否可以修改这些气候健康关系。 Co-i Dr. 拉德·基思（Ladd Keith 弹性计分卡（PIRS）的弹药计划集成，这是在某些城市公开使用的。 其他几个气候弹性因素（例如，过境路线，冷却中心，树冠，外壳类型）是 尽管这些数据存在于不同的来源，但在不同 时间表和不同的决议。与集成数据可视化核心（IDVC）一起，我们将 合并，链接到健康成果，并发布将跨越数十年以上的数十年的数据 观察。这将促进广泛的数据使用情况，并加速其他研究人员的批判性研究 气候变化的缓解和建筑环境如何促进气候弹性。该提议将 另外还可以作为灼伤分析的展示，将保护健康数据与 可以通过集成数据可视化核心构建的在线仪表板获得的公共数据。