A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional Dyspepsia

一种了解功能性消化不良成人问题性回避/限制性饮食的生物行为方法

基本信息

批准号：
10841228
负责人：
Helen Burton Murray
金额：
$ 7.56万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-13 至 2026-09-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10841228
关键词：
Address Administrative Supplement Adult Advisory Committees Affect Aftercare Appetite Regulation Area Award Behavior Therapy Behavioral Biological Biological Markers Biological Response Modifier Therapy Body Image Body Weight decreased Cholecystokinin Chronic Clinical Clinical Investigator Clinical Trials Cognitive Therapy Complement Data Data Collection Development Diet Dyspepsia Eating Eligibility Determination Endocrine Enrollment Enteral Feeding Epigastric Essential worker Evaluation Exposure to Food Future Gastroparesis Goals Health Care Costs Hormones Impairment Individual Intervention Investigation K-Series Research Career Programs Learning Malnutrition Medical Mentors Mentorship Morbidity - disease rate Motor Nausea Nutritional status Outcome Pain Parents Patients Peptide YY Phase Protocols documentation Psychologist Quality of life Randomized Randomized, Controlled Trials Research Role Satiation Scientist Sensorimotor functions Severities Stomach Symptoms Training avoidant restrictive food intake disorder behavioral clinical trial biobehavior biopsychosocial career development cohort dietary approach early satiety experience feasibility testing food avoidance gastrointestinal improved improved outcome innovation interdisciplinary approach meetings motility disorder patient oriented research pilot test preservation programs restrictive eating satisfaction skills social success symptom management timeline translational scientist treatment as usual treatment research

项目摘要

PROJECT SUMMARY/ABSTRACT Functional dyspepsia (FD) is a chronic gastrointestinal functional/motility disorder that affects up to 12% of US adults with significant morbidity and healthcare costs and has limited treatment options. Detrimental eating- related medical consequences are frequent in FD, with a level of food avoidance/restriction meeting criteria for avoidant/restrictive food intake disorder (ARFID) in up to 40% of adults with FD. However, the biological mechanisms of problematic avoidant/restrictive eating in FD have been underexplored and could inform behavioral and biological intervention targets. This 5-year K23-Patient-Oriented Research Career Development award addresses this research gap by using an innovative, multi-disciplinary approach to examine: (1) differences in gastric sensorimotor functions and satiety hormones among adults with FD and ARFID, FD without ARFID, and healthy controls; and (2) pilot feasibility, preliminary clinical outcomes, and preliminary mechanisms of an exposure-based cognitive-behavioral treatment in patients with FD and ARFID. This project represents the first exploration of the mechanistic role of problematic avoidant/restrictive eating in FD and the potential benefit of an intervention that exposes patients with FD to increased food volume/variety. The training plan corresponding to this project will support Dr. Helen Burton Murray in becoming an independent clinical scientist with a program of research examining biopsychosocial target mechanisms of gastrointestinal functional/motility disorders to inform behavioral and biological treatment interventions. The study aims complement Dr. Burton Murray’s objectives for her advancement as an independent clinical and translational investigator, achieved through four training areas: gastric sensorimotor functions, endocrine regulation of appetite, behavioral clinical trials evaluation and treatment mechanisms, and career development. Training goals will be implemented under the guidance of Dr. Braden Kuo (primary mentor); Drs. Elizabeth A. Lawson and Jennifer J. Thomas (co-mentors); Drs. Brjánn Ljótsson and Brian Healy (consultants); and Drs. Lukas Van Oudenhove, Johnathan Williams, and Laurie Keefer (scientific advisory committee). The purpose of this proposed supplement award is to provide Dr. Burton Murray with essential staff support during the most active data collection year planned. Supplement support will preserve the success of Dr. Burton Murray in achieving the above aims and facilitate her successful K-to-R transition.

项目摘要/摘要功能性消化不良（FD）是一种慢性胃肠道功能/运动障碍，最多影响我们12％发病率明显和医疗保健成本的成年人的治疗选择有限。有害饮食 - 相关医疗后果经常出现在FD中，避免食物/限制的水平符合标准多达40％的FD成年人中，回避/限制性食品摄入障碍（ARFID）。但是，生物学 FD中有问题的回避/限制性饮食机制尚未得到充实，并且可以告知行为和生物学干预目标。这项为期5年的K23患者研究职业发展奖项通过使用创新的多学科考试方法来解决这一研究差距：（1） FD和ARFID成年人的胃感觉运动功能和饱腹感恐怖片的差异没有ARFID和健康的对照；（2）试验可行性，初步临床结果和初步 FD和ARFID患者的基于暴露的认知行为治疗的机制。这个项目代表了有问题的回避/限制性饮食在FD和干预措施的潜在好处，该干预措施使FD患者暴露于食物量/品种增加。培训与该项目相对应的计划将支持Helen Burton Murray博士成为独立的临床科学家通过研究胃肠道的生物心理社会目标机制的研究计划功能/运动障碍，以告知行为和生物治疗干预措施。该研究的目的补充伯顿·默里（Burton Murray）博士作为独立临床和翻译的进步目标研究人员通过四个训练领域实现：胃感觉运动功能，内分泌调节食欲，行为临床试验评估和治疗机制以及职业发展。训练目标将在Braden Kuo博士（主要导师）的指导下实施；博士。伊丽莎白·劳森（Elizabeth A. Lawson）詹妮弗·J·托马斯（Jennifer J. Thomas）（联合官）；博士。 BrjánnLjótsson和Brian Healy（顾问）；和博士。卢卡货车 Oudenhove，Johnathan Williams和Laurie Keefer（科学咨询委员会）。这个目的拟议的补充剂奖是为了在伯顿·默里博士（Burton Murray）计划最活跃的数据收集年度。补充支持将保留伯顿博士的成功穆雷（Murray）实现上述目标并促进了她成功的K-to-r过渡。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Validation of the youth-nine item avoidant/restrictive food intake disorder screen.

青少年九项回避/限制性食物摄入障碍筛查的验证。

DOI：
10.1002/erv.3017
发表时间：
2024
期刊：
European eating disorders review : the journal of the Eating Disorders Association
影响因子：
0
作者：
BillmanMiller,MarleyG;Zickgraf,HanaF;Murray,HelenBurton;Essayli,JamalH;Lane-Loney,SusanE
通讯作者：
Lane-Loney,SusanE

Psychological Considerations in the Dietary Management of Patients With DGBI.

DOI：
10.14309/ajg.0000000000001766
发表时间：
2022-06-01
期刊：
The American journal of gastroenterology
影响因子：
0
作者：
通讯作者：

Does Gluten Avoidance in Patients with Celiac Disease Increase the Risk of Developing Eating Disorders?

乳糜泻患者避免麸质是否会增加饮食失调的风险？

DOI：
10.1007/s10620-023-07915-3
发表时间：
2023
期刊：
Digestive diseases and sciences
影响因子：
3.1
作者：
Abber,SophieR;BurtonMurray,Helen
通讯作者：
BurtonMurray,Helen

Assessing the presence and motivations of orthorexia nervosa among athletes and adults with eating disorders: a cross-sectional study.

DOI：
10.1007/s40519-023-01631-7
发表时间：
2023-12-09
期刊：
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
影响因子：
2.9
作者：
Foyster, Mandy;Sultan, Nessmah;Tonkovic, Matilda;Govus, Andrew;Burton-Murray, Helen;Tuck, Caroline J.;Biesiekierski, Jessica R.
通讯作者：
Biesiekierski, Jessica R.

Identification and Management of Eating Disorders (including ARFID) in GI Patients.

胃肠道患者饮食失调（包括 ARFID）的识别和管理。