A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional Dyspepsia

一种了解功能性消化不良成人问题性回避/限制性饮食的生物行为方法

基本信息

批准号：
10696092
负责人：
Helen Burton Murray
金额：
$ 19.95万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-13 至 2026-09-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10696092
关键词：
Address Adult Advisory Committees Affect Aftercare Appetite Regulation Applications Grants Area Behavior Therapy Behavioral Biological Biological Markers Biological Response Modifier Therapy Body Image Body Weight decreased Cholecystokinin Chronic Clinical Clinical Investigator Clinical Trials Cognitive Therapy Complement Data Development Diet Dyspepsia Eating Eligibility Determination Endocrine Enrollment Enteral Feeding Epigastric Evaluation Exposure to Food Future Gastroenterology Gastroparesis Goals Health Care Costs Hormones Impairment Individual Intervention K-Series Research Career Programs Learning Malnutrition Medical Mentors Mentorship Morbidity - disease rate Motor National Institute of Diabetes and Digestive and Kidney Diseases Nausea Nutritional status Outcome Pain Patients Peptide YY Phase Preparation Protocols documentation Psychologist Psychology Quality of life Randomized Randomized, Controlled Trials Research Research Personnel Research Priority Role Satiation Scientist Sensorimotor functions Severities Stomach Symptoms Testing Training United States National Institutes of Health avoidant restrictive food intake disorder behavioral clinical trial behavioral study biobehavior biopsychosocial career development cohort dietary approach early satiety experience food avoidance gastrointestinal improved improved outcome innovation interdisciplinary approach meetings motility disorder multidisciplinary patient oriented research pilot test programs restrictive eating satisfaction skills social symptom management translational scientist treatment as usual treatment research

Address Adult Advisory Committees Affect Aftercare Appetite Regulation Applications Grants Area Behavior Therapy Behavioral Biological Biological Markers Biological Response Modifier Therapy Body Image Body Weight decreased Cholecystokinin Chronic Clinical Clinical Investigator Clinical Trials Cognitive Therapy Complement Data Development Diet Dyspepsia Eating Eligibility Determination Endocrine Enrollment Enteral Feeding Epigastric Evaluation Exposure to Food Future Gastroenterology Gastroparesis Goals Health Care Costs Hormones Impairment Individual Intervention K-Series Research Career Programs Learning Malnutrition Medical Mentors Mentorship Morbidity - disease rate Motor National Institute of Diabetes and Digestive and Kidney Diseases Nausea Nutritional status Outcome Pain Patients Peptide YY Phase Preparation Protocols documentation Psychologist Psychology Quality of life Randomized Randomized, Controlled Trials Research Research Personnel Research Priority Role Satiation Scientist Sensorimotor functions Severities Stomach Symptoms Testing Training United States National Institutes of Health avoidant restrictive food intake disorder behavioral clinical trial behavioral study biobehavior biopsychosocial career development cohort dietary approach early satiety experience food avoidance gastrointestinal improved improved outcome innovation interdisciplinary approach meetings motility disorder multidisciplinary patient oriented research pilot test programs restrictive eating satisfaction skills social symptom management translational scientist treatment as usual treatment research

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项目摘要

PROJECT SUMMARY/ABSTRACT Functional dyspepsia (FD) is a chronic gastrointestinal functional/motility disorder that affects up to 12% of US adults with significant morbidity and healthcare costs and has limited treatment options. Detrimental eating- related medical consequences are frequent in FD, with a level of food avoidance/restriction meeting criteria for avoidant/restrictive food intake disorder (ARFID) in up to 40% of adults with FD. However, the biological mechanisms of problematic avoidant/restrictive eating in FD have been underexplored and could inform behavioral and biological intervention targets. This 5-year K23-Patient-Oriented Research Career Development award addresses this research gap by using an innovative, multi-disciplinary approach to examine: (1) differences in gastric sensorimotor functions and satiety hormones among adults with FD and ARFID, FD without ARFID, and healthy controls; and (2) pilot feasibility, preliminary efficacy, and preliminary mechanisms of an exposure-based cognitive-behavioral treatment in patients with FD and ARFID. This project represents the first exploration of the mechanistic role of problematic avoidant/restrictive eating in FD and the potential benefit of an intervention that exposes patients with FD to increased food volume/variety. The training plan corresponding to this project will support Dr. Helen Burton Murray in becoming an independent clinical scientist with a program of research examining biopsychosocial target mechanisms of gastrointestinal functional/motility disorders to inform behavioral and biological treatment interventions. The study aims complement Dr. Burton Murray’s objectives for her advancement as an independent clinical and translational investigator, achieved through four training areas: gastric sensorimotor functions, endocrine regulation of appetite, behavioral clinical trials evaluation and treatment mechanisms, and career development. Training goals will be implemented under the guidance of Dr. Braden Kuo (primary mentor); Drs. Elizabeth A. Lawson and Jennifer J. Thomas (co- mentors); Drs. Brjánn Ljótsson and Brian Healy (consultants); and Drs. Lukas Van Oudenhove, Johnathan Williams, and Laurie Keefer (scientific advisory committee).

项目摘要/摘要功能性消化不良（FD）是一种慢性胃肠道功能/运动障碍，最多影响我们12％发病率明显和医疗保健成本的成年人的治疗选择有限。有害饮食 - 相关医疗后果经常出现在FD中，避免食物/限制的水平符合标准多达40％的FD成年人中，回避/限制性食品摄入障碍（ARFID）。但是，生物学 FD中有问题的回避/限制性饮食机制尚未得到充实，并且可以告知行为和生物学干预目标。这项为期5年的K23患者研究职业发展奖项通过使用创新的多学科考试方法来解决这一研究差距：（1） FD和ARFID成年人的胃感觉运动功能和饱腹感恐怖片的差异没有ARFID和健康的对照；（2）试验可行性，初步效率和初步机制 FD和ARFID患者的基于暴露的认知行为治疗。该项目代表第一次探索有问题的回避/限制性饮食的机理作用以及潜力将FD患者暴露于食物量/种类增加的干预措施的益处。培训计划与该项目相对应的将支持海伦·伯顿·默里（Helen Burton Murray）博士成为一名独立的临床科学家通过研究胃肠道功能/运动的生物心理社会目标机制的研究计划为行为和生物治疗干预措施提供信息的疾病。这项研究的目的是完成伯顿博士默里（Murray）作为独立临床和翻译调查员的进步目标通过四个训练领域：胃感觉运动功能，食欲的内分泌调节，行为临床试验评估和治疗机制以及职业发展。将实施培训目标在Braden Kuo博士（主要导师）的指导下；博士。伊丽莎白·劳森（Elizabeth A. Lawson）和詹妮弗·J·托马斯（Jennifer J. Thomas）（共同博士。 BrjánnLjótsson和Brian Healy（顾问）；和博士。卢卡斯·范·乌登霍夫（Johnathan）威廉姆斯和劳里·基弗（Laurie Keefer）（科学咨询委员会）。