Clinical Center for NICHD/Neonatal Research Network

NICHD 临床中心/新生儿研究网络

基本信息

批准号：
10841989
负责人：
Sara Bonamo DeMauro
金额：
$ 33.55万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-01 至 2030-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10841989
关键词：
2 year old 21 year old 3 year old 4 year old Age Auditory Auditory area Birth Birth Weight Brain Brain imaging Child Clinical Data Data Collection Development Education Enrollment Faculty Frequencies Funding Generations Gestational Age Goals Hospitalization Image Individual Infant Institution Intervention Language Language Delays Language Development Language Disorders Language Therapy Magnetic Resonance Imaging Magnetoencephalography Measures Medical Medical center Meta-Analysis Methods Modeling Multicenter Neonatal Research Network National Institute of Child Health and Human Development Nature Neonatal Neurophysiology - biologic function Nursery Schools Outcome Outcome Measure Parents Participant Pediatric Hospitals Pennsylvania Perinatal Phase Philadelphia Premature Infant Procedures Process Qualifying Race Recording of previous events Research Research Personnel Resources Rest Risk Risk Factors Sampling Shapes Site Specificity Speech Therapy Speed Structure System Toddler Universities Vocabulary Test clinical center cognitive ability cohort developmental disease experience extreme prematurity gray matter high risk infant improved indexing interest language disorder diagnosis language impairment language outcome neonatal morbidity neural neural circuit neural network neuroimaging neuromechanism research clinical testing response sex skills sociodemographic factors sociodemographic predictors sociodemographics socioeconomics sound success white matter

项目摘要

ABSTRACT Children born extremely preterm (EP) (<27 weeks gestational age (GA)) are atincreased risk of having a languagedisorder or late language emergence 1-5. The proposed study seeks to identify the neural circuit mechanisms and socio-demographic factors that contribute to variable language outcome in extremely preterm (EP) children at 3 years corrected age (CA). This supplemental funding application is submitted as one of a pair of applications from the University of Pennsylvania/Children's Hospital of Philadelphia (Penn/CHOP) and Cincinnati Children's Hospital Medical Center (CCHMC). The PIs at Penn/CHOP and CCHMC, Drs. DeMauro and Merhar, are PIs of the NICHD Neonatal Research Network (NRN) Clinical Centers at their respective institutions, which serve as the parent studies for the current proposal. The NRN follows all infants born EP and other high-risk infants from birth to 22-26 months CA, collecting developmental outcomes and therapies received, and perinatal, medical, and socio-demographic data. For the proposed project, they engaged highly motivated and qualified junior faculty with expertise in neural imaging and language development from both sites (Dr. Chen from CHOP; Dr. Barnes-Davis from CCHMC). The proposed study employs a suite of magnetoencephalography (MEG) neural measures and language assessments to evaluate if task-based neural measures are differentially associated with variable receptive and expressive language outcome in EP children at 3 years CA in comparison to term-born controls (TC) children. Using tasks developed by Dr. Chen and Dr. Barnes-Davis, neural measures of interest are: (1) auditory encoding processes = M50 latency 6-15, (2) functional connectivity during receptive (story listening) and expressive (verb generation) language processes = weighted phase lag index (wPLI) 16, 17, and (3) resting-state (RS) peak alpha frequency (PAF), a brain rhythm associated with connectivity between neural networks 18-20. Leveraging both the existing CHOP NRN cohort with neonatal and completed developmental data at age 2 years and a CHOP longitudinal TC cohort who have completed longitudinal neuroimaging and developmental data from birth to age 2, MEG and language measures will be obtained in 60 EP and 60 TC children at 3-3.5 years CA. The same MEG task data and language outcome measures will be obtained in the EP and TC cohorts at CCHMC, for a total enrollment of 100 EP and 100 TC participants across two sites, enhancing the power and generalizability of the proposed study. Sharing of methods and data across the two centers permits rapid and efficient data collection of a socioeconomically diverse EP sample. It is anticipated that the elucidation of neural risk factors will provide increased specificity to the nature of variable language outcome in young children born EP. Study findings are also expected to lead to timely and more tailored clinical interventions that shape the maturation of language neural networks and specifically meet the goal of the TALK NOSI, “to engage in activities that will help to elucidate the unique trajectories and needs of late talking children.”

抽象的极早产 (EP) 儿童（胎龄<27 周 (GA)）发生妊娠的风险增加语言障碍或语言出现较晚 1-5. 本研究旨在确定神经回路。在极端情况下导致不同语言结果的机制和社会人口因素校正年龄 (CA) 为 3 岁的早产 (EP) 儿童此补充资助申请是作为以下内容提交的。宾夕法尼亚大学/费城儿童医院的两份申请之一 (Penn/CHOP) 和辛辛那提儿童医院医疗中心 (CCHMC)。 Penn/CHOP 的 PI 和 CCHMC、DeMauro 和 Merhar 博士是 NICHD 新生儿研究网络 (NRN) 临床中心的 PI 在各自的机构中，这些机构作为当前提案的家长研究。出生的 EP 婴儿和其他高危婴儿从出生到 22-26 个月 CA，收集发育结果对于所提出的项目，他们提供了所接受的治疗、围产期、医学和社会人口统计数据。聘请了具有神经成像和语言专业知识、积极性高、合格的初级教师两个地点的开发（来自 CHOP 的 Chen 博士；来自 CCHMC 的 Barnes-Davis 博士）。采用一套脑磁图 (MEG) 神经测量和语言评估来评估基于任务的神经测量是否与可变的接受性和表达性语言有差异相关与足月出生的对照 (TC) 儿童相比，3 岁 CA 的 EP 儿童的结果使用任务。由 Chen 博士和 Barnes-Davis 博士开发，感兴趣的神经测量是：（1）听觉编码过程 = M50 延迟 6-15，(2) 接受（听故事）和表达（动词）期间的功能连接生成）语言过程 = 加权相位滞后指数 (wPLI) 16、17 和 (3) 静息态 (RS) 峰值 alpha 频率（PAF），一种与神经网络之间的连接相关的大脑节律 18-20。现有的 CHOP NRN 队列，包含新生儿和 2 岁时完整的发育数据以及 CHOP 已完成从出生到出生期间的纵向神经影像和发育数据的纵向 TC 队列将在 3-3.5 岁 CA 的 60 名 EP 和 60 名 TC 儿童中获得 2 岁 MEG 和语言测量结果。 CCHMC 的 EP 和 TC 队列将获得相同的 MEG 任务数据和语言结果测量，两个站点的总注册人数为 100 名 EP 和 100 名 TC 参与者，增强了力量和两个中心之间共享方法和数据可以实现快速和普遍的研究。预计可以阐明社会多样化的 EP 样本的有效数据。神经危险因素将为年轻人的可变语言结果的性质提供更高的特异性出生的 EP 儿童的研究结果也有望带来及时、更有针对性的临床干预措施。塑造语言神经网络的成熟，并具体实现 TALK NOSI 的目标，“ 参与有助于阐明说话晚的孩子的独特轨迹和需求的活动。”