Clinical Center for NICHD/Neonatal Research Network

NICHD 临床中心/新生儿研究网络

• 批准号: 10841989
• 负责人: Sara Bonamo DeMauro
• 金额: $ 33.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2030-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10841989
• 关键词: 2 year old; 21 year old; 3 year old; 4 year old; Age; Auditory; Auditory area; Birth; Birth Weight; Brain; Brain imaging; Child; Clinical; Data; Data Collection; Development; Education; Enrollment; Faculty; Frequencies; Funding; Generations; Gestational Age; Goals; Hospitalization; Image; Individual; Infant; Institution; Intervention; Language; Language Delays; Language Development; Language Disorders; Language Therapy; Magnetic Resonance Imaging; Magnetoencephalography; Measures; Medical; Medical center; Meta-Analysis; Methods; Modeling; Multicenter Neonatal Research Network; National Institute of Child Health and Human Development; Nature; Neonatal; Neurophysiology - biologic function; Nursery Schools; Outcome; Outcome Measure; Parents; Participant; Pediatric Hospitals; Pennsylvania; Perinatal; Phase; Philadelphia; Premature Infant; Procedures; Process; Qualifying; Race; Recording of previous events; Research; Research Personnel; Resources; Rest; Risk; Risk Factors; Sampling; Shapes; Site; Specificity; Speech Therapy; Speed; Structure; System; Toddler; Universities; Vocabulary Test; clinical center; cognitive ability; cohort; developmental disease; experience; extreme prematurity; gray matter; high risk infant; improved; indexing; interest; language disorder diagnosis; language impairment; language outcome; neonatal morbidity; neural; neural circuit; neural network; neuroimaging; neuromechanism; research clinical testing; response; sex; skills; sociodemographic factors; sociodemographic predictors; sociodemographics; socioeconomics; sound; success; white matter

ABSTRACT Children born extremely preterm (EP) (<27 weeks gestational age (GA)) are atincreased risk of having a languagedisorder or late language emergence 1-5. The proposed study seeks to identify the neural circuit mechanisms and socio-demographic factors that contribute to variable language outcome in extremely preterm (EP) children at 3 years corrected age (CA). This supplemental funding application is submitted as one of a pair of applications from the University of Pennsylvania/Children's Hospital of Philadelphia (Penn/CHOP) and Cincinnati Children's Hospital Medical Center (CCHMC). The PIs at Penn/CHOP and CCHMC, Drs. DeMauro and Merhar, are PIs of the NICHD Neonatal Research Network (NRN) Clinical Centers at their respective institutions, which serve as the parent studies for the current proposal. The NRN follows all infants born EP and other high-risk infants from birth to 22-26 months CA, collecting developmental outcomes and therapies received, and perinatal, medical, and socio-demographic data. For the proposed project, they engaged highly motivated and qualified junior faculty with expertise in neural imaging and language development from both sites (Dr. Chen from CHOP; Dr. Barnes-Davis from CCHMC). The proposed study employs a suite of magnetoencephalography (MEG) neural measures and language assessments to evaluate if task-based neural measures are differentially associated with variable receptive and expressive language outcome in EP children at 3 years CA in comparison to term-born controls (TC) children. Using tasks developed by Dr. Chen and Dr. Barnes-Davis, neural measures of interest are: (1) auditory encoding processes = M50 latency 6-15, (2) functional connectivity during receptive (story listening) and expressive (verb generation) language processes = weighted phase lag index (wPLI) 16, 17, and (3) resting-state (RS) peak alpha frequency (PAF), a brain rhythm associated with connectivity between neural networks 18-20. Leveraging both the existing CHOP NRN cohort with neonatal and completed developmental data at age 2 years and a CHOP longitudinal TC cohort who have completed longitudinal neuroimaging and developmental data from birth to age 2, MEG and language measures will be obtained in 60 EP and 60 TC children at 3-3.5 years CA. The same MEG task data and language outcome measures will be obtained in the EP and TC cohorts at CCHMC, for a total enrollment of 100 EP and 100 TC participants across two sites, enhancing the power and generalizability of the proposed study. Sharing of methods and data across the two centers permits rapid and efficient data collection of a socioeconomically diverse EP sample. It is anticipated that the elucidation of neural risk factors will provide increased specificity to the nature of variable language outcome in young children born EP. Study findings are also expected to lead to timely and more tailored clinical interventions that shape the maturation of language neural networks and specifically meet the goal of the TALK NOSI, “to engage in activities that will help to elucidate the unique trajectories and needs of late talking children.”

抽象的 出生的儿童非常早产（EP）（<27周的妊娠年龄（GA））患有A的风险 语言序或后期语言出现1-5。拟议的研究旨在识别神经回路 在极端的语言结果中有助于可变语言结果的机制和社会人口统计学因素 30岁的早产（EP）儿童（CA）。该补充资金申请被提交为 来自宾夕法尼亚大学/费城儿童医院的两对申请 （Penn/Chop）和辛辛那提儿童医院医疗中心（CCHMC）。 Penn/Chop的PI和 CCHMC，博士。 DeMauro和Merhar是NICHD新生儿研究网络（NRN）临床中心的PI 在各自的机构中，这些机构是当前提案的父母研究。 NRN遵循所有 从出生到22-26个月的婴儿出生的EP和其他高风险婴儿CA，收集发展结果 以及接受的疗法以及围产期，医学和社会人口统计学数据。对于拟议的项目，他们 具有神经成像和语言专业知识的高度积极进取和合格的初级教师 两个地点的开发（Chop的Chen博士； CCHMC的Barnes-Davis博士）。拟议的研究 员工一套磁脑摄影（MEG）神经测量和语言评估以评估 如果基于任务的神经测量与可变的接受语言有不同的相关性 与期限对照组（TC）儿童相比，EP儿童的EP儿童的结局。使用任务 由Chen博士和Barnes-Davis博士开发的，感兴趣的神经度量是：（1）听觉编码 过程= M50延迟6-15，（2）接受（故事听）和表达的功能连接性（动词） 一代）语言过程=加权相位滞后指数（WPLI）16、17和（3）静止状态（RS）峰alpha 频率（PAF），一种与神经网络之间的连通性相关的脑节奏18-20。利用这两个 现有的Chop NRN队列具有新生儿，并在2岁时完成了开发数据和CHOP 从出生到 2岁的MEG和语言测量将在60年代和60个TC儿童中获得3-3.5岁儿童。这 在CCHMC的EP和TC队列中，将获得相同的MEG任务数据和语言结果指标， 对于两个站点的总入学人数为100 EP和100 TC参与者，从而增强了功率和 拟议研究的概括性。在两个中心之间共享方法和数据允许快速和 社会经济多样的EP样本的有效数据收集。预计阐明 神经风险因素将为年轻人的可变语言结果的性质提供更高的特异性 出生的儿童EP。研究结果也有望导致时间和更量身定制的临床干预措施 塑造语言神经网络的成熟，并特别符合Talk Nosi的目标，“ 参与将有助于阐明已说话的孩子的独特轨迹和需求的活动。”