Integrating social and molecular determinants of HPV-associated cancers

整合 HPV 相关癌症的社会和分子决定因素

基本信息

批准号：
10821615
负责人：
Angela Liu Mazul
金额：
$ 12.33万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-06 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10821615
关键词：
Affect African American Anus Area Behavioral Biology Cancer Biology Cancer Center Cancer Etiology Career Mobility Censuses Cervical Clinical Communication Communities Complement Complex Data Databases Demographic Factors Development Disease Epidemiologic Methods Epidemiology Equity Failure Genomics Genotype Geographic Information Systems Geography Goals HPV oropharyngeal cancer Health Services Accessibility Human Papilloma Virus Vaccination Human Papilloma Virus-Related Malignant Neoplasm Human Papillomavirus Human papilloma virus infection Human papillomavirus 16 Incidence Intervention Knowledge Link Location Malignant Neoplasms Malignant neoplasm of anus Malignant neoplasm of cervix uteri Maps Measures Mediating Medical Methods Missouri Modeling Molecular Molecular Epidemiology Neighborhoods Obesity Oral cavity Oropharyngeal Outcome Population Positioning Attribute Prevalence Prevention Primary Care Primary Prevention Recommendation Reduce health disparities Research Research Personnel Research Proposals Risk Factors Risk Reduction Role Rural Sampling Screening for cancer Secondary Prevention Smoking Socioeconomic Status Source Stage at Diagnosis Training Tumor Bank Tumor Markers United States Vaccination Vulnerable Populations Woman Work Youth cancer epidemiology cancer health disparity cancer risk career data registry disparity reduction economic disparity experience follow-up health disparity high risk population indexing innovation insight knowledge base malignant mouth neoplasm malignant oropharynx neoplasm medically underserved molecular marker mortality optimal treatments preventive intervention prognostic significance prognostication programs repository rural area screening sexual debut skill acquisition skills social social epidemiology social factors social health determinants socioeconomics suburb transportation access tumor underserved area

项目摘要

PROJECT SUMMARY/ABSTRACT Human Papillomavirus (HPV)-associated cancer has been dramatically rising for the last few decades. The development and implementation of HPV vaccination and screening provide the promise of prevention. Primary prevention and advances in genomic prognostication has shifted the landscape of HPV-associated cancers. Efficacious and equitable prevention and treatment efforts for vulnerable groups requires an understanding of geographic, social and molecular determinants of HPV-associated cancers unique to these underserved and understudied populations. The goal of this proposed research proposal is to study how social determinants of health influences and interacts with molecular tumor markers to affect HPV-associated cancers. Dr. Mazul’s career goal is to become an independent researcher who is uniquely positioned to develop, conduct, and communicate research bridging cancer social determinant of health biology with social epidemiology. In the proposed training plan, Dr. Mazul will build upon her cancer epidemiologic skills to develop additional expertise in geospatial analysis and social epidemiologic methods, while expanding her cancer knowledge into HPV- associated cancer biology. Her training will be directly applied to support and advance her career as an independent researcher and the proposed research plan. Geospatial and social epidemiologic methods will be employed to understanding the interaction between social and molecular factors. We will use data from three sources representing national, Missouri statewide and local St. Louis HPV-associated cancer cases to compare the three most common HPV-associated cancers (oropharyngeal, cervical and anal). Three aims will address the overall hypothesis that poor neighborhood-level factors interact with molecular markers and to lead to poor HPV-associated cancer outcomes. Aim 1. Identify nationwide and statewide spatial clusters of HPV-associated cancers using geographic information systems and geospatial modeling. Aim 2: Measure the effect of neighborhood-level social and demographic factors on HPV- associated cancer stage at presentation and survival. Aim 3: Measure the prevalence and prognostic significance of HPV genotype in a demographically and socioeconomically diverse HPV-associated cancer population. Results from this study will provide a more nuanced assessment of the complex social and genomic factors linked with HPV-associated cancer. With this training and experience, Dr. Mazul will be well positioned to launch her independent research career.

项目摘要/摘要在过去的几十年中，与人乳头瘤病毒（HPV）相关的癌症一直在急剧上升 HPV疫苗接种和生产筛查的开发和实施。预防和基因组预后的进步改变了与HPV相关癌症的景观。弱势群体的有效，公平的预防和治疗源 HPV相关的癌症的地球文化，社会和分子决定因素，这些癌症是这些繁重的癌症研究了拟议研究的目标健康影响并与分子肿瘤标记物相互作用，以影响与HPV相关的癌症。马祖尔博士的职业目标是成为一名独特的研究人员，他在开发，行为和行为方面拥有独特的位置。并在您的社会中传达了健康生物学的社会决定因素。支撑培训计划，Mazul Will Will Will博士将根据其癌症流行病学技能来发展额外的专业知识在地理空间分析和社会流行病方法中，将她的癌症知识扩展到HPV- 相关的癌症生物学。独立的研究人员和支撑研究计划。地理空间和社会流行病学方法将用于理解社会之间的相互作用和分子因素。路易斯HPV相关的癌症病例，比较了三种苔藓的HPV相关癌症（口咽，宫颈和肛门）。因素与分子标记物相互作用，并导致HPV相关的癌症结果1 使用地理信息系统和地理空间建模。相关的癌症阶段和生存3：测量预后意义人口统计学和社会经济多样性多样化的HPV相关癌症种群中的HPV基因型。研究的结果将对复杂的社会和基因组因素进行更细微的评估与HPV的癌症有关。她的独立研究生涯。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The prognostic significance of race in nasopharyngeal carcinoma by histological subtype.

DOI：
10.1002/hed.26639
发表时间：
2021-06
期刊：
Head & neck
影响因子：
0
作者：
Stepan KO;Mazul AL;Skillington SA;Paniello RC;Rich JT;Zevallos JP;Jackson RS;Pipkorn P;Massa S;Puram SV
通讯作者：
Puram SV