Integrating social and molecular determinants of HPV-associated cancers

整合 HPV 相关癌症的社会和分子决定因素

基本信息

批准号：
10312815
负责人：
Angela Liu Mazul
金额：
$ 12.98万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-06 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10312815
关键词：
Address Affect African American Anus Area Biology Cancer Biology Cancer Center Cancer Etiology Censuses Cervical Clinical Communities Complement Complex Data Databases Demographic Factors Development Disease Epidemiologic Methods Epidemiology Genomics Genotype Geographic Information Systems Geography Goals HPV oropharyngeal cancer Health Services Accessibility Human Papilloma Virus Vaccination Human Papilloma Virus-Related Malignant Neoplasm Human Papillomavirus Human papilloma virus infection Human papillomavirus 16 Incidence Individual Intervention Knowledge Lead Link Location Malignant Neoplasms Malignant neoplasm of anus Malignant neoplasm of cervix uteri Maps Measures Mediating Medical Methods Missouri Modeling Molecular Molecular Epidemiology Neighborhoods Obesity Oral cavity Oropharyngeal Outcome Population Positioning Attribute Prevalence Prevention Primary Health Care Primary Prevention Reduce health disparities Research Research Personnel Research Proposals Risk Risk Factors Role Rural Sampling Screening for cancer Secondary Prevention Smoking Socioeconomic Status Source Stage at Diagnosis Training Treatment Failure Tumor Bank Tumor Markers United States Vaccination Vulnerable Populations Woman Work Youth behavioral genomics cancer health disparity cancer risk career data registry disparity reduction experience follow-up health disparity high risk indexing innovation insight knowledge base malignant mouth neoplasm malignant oropharynx neoplasm medically underserved molecular marker mortality optimal treatments preventive intervention prognostic significance prognostication programs repository rural area screening sexual debut skills social social epidemiology social factors social genomics social health determinants social integration socioeconomics suburb transportation access tumor underserved area

项目摘要

PROJECT SUMMARY/ABSTRACT Human Papillomavirus (HPV)-associated cancer has been dramatically rising for the last few decades. The development and implementation of HPV vaccination and screening provide the promise of prevention. Primary prevention and advances in genomic prognostication has shifted the landscape of HPV-associated cancers. Efficacious and equitable prevention and treatment efforts for vulnerable groups requires an understanding of geographic, social and molecular determinants of HPV-associated cancers unique to these underserved and understudied populations. The goal of this proposed research proposal is to study how social determinants of health influences and interacts with molecular tumor markers to affect HPV-associated cancers. Dr. Mazul’s career goal is to become an independent researcher who is uniquely positioned to develop, conduct, and communicate research bridging cancer social determinant of health biology with social epidemiology. In the proposed training plan, Dr. Mazul will build upon her cancer epidemiologic skills to develop additional expertise in geospatial analysis and social epidemiologic methods, while expanding her cancer knowledge into HPV- associated cancer biology. Her training will be directly applied to support and advance her career as an independent researcher and the proposed research plan. Geospatial and social epidemiologic methods will be employed to understanding the interaction between social and molecular factors. We will use data from three sources representing national, Missouri statewide and local St. Louis HPV-associated cancer cases to compare the three most common HPV-associated cancers (oropharyngeal, cervical and anal). Three aims will address the overall hypothesis that poor neighborhood-level factors interact with molecular markers and to lead to poor HPV-associated cancer outcomes. Aim 1. Identify nationwide and statewide spatial clusters of HPV-associated cancers using geographic information systems and geospatial modeling. Aim 2: Measure the effect of neighborhood-level social and demographic factors on HPV- associated cancer stage at presentation and survival. Aim 3: Measure the prevalence and prognostic significance of HPV genotype in a demographically and socioeconomically diverse HPV-associated cancer population. Results from this study will provide a more nuanced assessment of the complex social and genomic factors linked with HPV-associated cancer. With this training and experience, Dr. Mazul will be well positioned to launch her independent research career.

项目概要/摘要过去几十年来，与人乳头瘤病毒 (HPV) 相关的癌症急剧上升。 HPV 疫苗接种和筛查的开发和实施为初级预防提供了希望。预防和基因组预测的进步已经改变了 HPV 相关癌症的面貌。对弱势群体进行有效和公平的预防和治疗工作需要了解 HPV 相关癌症的地理、社会和分子决定因素是这些服务不足和本研究提案的目标是研究社会决定因素如何影响未充分研究的人群。健康影响分子肿瘤标志物并与之相互作用，从而影响 HPV 相关癌症。 Mazul 博士的职业目标是成为一名独立研究员，他具有独特的优势来开发、开展、并交流将健康生物学的癌症社会决定因素与社会流行病学联系起来的研究。根据拟议的培训计划，Mazul 博士将利用她的癌症流行病学技能来发展更多的专业知识她在地理空间分析和社会流行病学方法方面拥有丰富的经验，同时将她的癌症知识扩展到 HPV- 她的培训将直接应用于支持和推进她作为一名癌症生物学家的职业生涯。独立研究员和拟议的研究计划。将采用地理空间和社会流行病学方法来了解社会之间的相互作用我们将使用来自代表国家、密苏里州和地方的三个来源的数据。圣路易斯 HPV 相关癌症病例比较三种最常见的 HPV 相关癌症（口咽、颈部和肛门）。三个目标将解决贫困社区层面的总体假设。因素与分子标志物相互作用并导致 HPV 相关癌症结果不佳。使用地理信息系统和 HPV 相关癌症的全国和全县空间集群目标 2：测量社区层面的社会和人口因素对 HPV 的影响。目标 3：测量患病率和预后意义。人口统计和社会多样化的 HPV 相关癌症人群中 HPV 基因型的研究。这项研究的结果将为复杂的社会和基因组因素提供更细致的评估凭借这些培训和经验，Mazul 博士将能够很好地推出与 HPV 相关的癌症。她的独立研究生涯。