Feasibility of app-delivered circadian synchronization therapy with light in a cohort of pregnant women

应用程序提供的光昼夜节律同步治疗对孕妇队列的可行性

• 批准号: 10823065
• 负责人: Olivia Walch
• 金额: $ 29.51万
• 依托单位: ARCASCOPE, INC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-11 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10823065
• 关键词: Adult; Algorithms; Android; Apple watch; Behavior; Behavioral; Businesses; Caffeine; Circadian Dysregulation; Circadian Rhythms; Clinical Trials; Collection; Data; Dedications; Development; Elements; Exercise; Exposure to; Fatigue; Feedback; Gestational Diabetes; Glass; Goals; Health; Hour; Individual; Infant; Intervention; Light; Lighting; Link; Malignant Neoplasms; Maternal Health; Moods; Mothers; Napping; Outcome; Phase; Play; Population Heterogeneity; Population Intervention; Postpartum Depression; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Prevention; Recommendation; Reporting; Research; Risk; Risk Reduction; Role; Sleep; Small Business Innovation Research Grant; Small Business Technology Transfer Research; System; Testing; Time; Training; Travel; Update; Work; circadian; circadian pacemaker; cohort; diagnostic technologies; diaries; improved; improved outcome; innovation; interest; mobile application; patient population; personalized intervention; post pregnancy; pregnant; prevent; prototype; real time monitoring; response; sensor; smartphone application; socioeconomics; success; technological innovation; usability

PROJECT SUMMARY Circadian rhythms play a vital role in promoting maternal health and managing pregnancy outcomes, including gestational diabetes, preterm birth, and postpartum depression. However, interventions to mitigate circadian rhythms disruption during pregnancy are lacking, despite readily available non-pharmacological circadian interventions. The circadian timekeeping system is strengthened and aligned to the 24-hour day by light, and environmental light manipulations can shift the phase and alter the amplitude of circadian rhythms when based on careful timing and combined with other behaviors. This Phase I STTR project aims to evaluate the feasibility of circadian synchronization therapy with light (CST-L) in a socioeconomically diverse population of pregnant women. The intervention involves bright light exposure at specific times to phase advance, delay, or boost the amplitude of the circadian clock, dim light at other times, as well as the use of a diary to track the causes of circadian disruption. To evaluate the success of the trial, we will collect subjective feedback from 20 pregnant women using the app and blue-blocking glasses for four weeks, and will make iterative updates to the app in response to user feedback. The ultimate goal is to develop a mobile application for both iOS and Android that delivers CST-L and helps improve maternal mood and health, as well as infant sleep training. If successful, this intervention could help reduce the risk of preterm birth, postpartum depression, and other poor outcomes during and after pregnancy.

项目摘要 昼夜节律在促进孕产妇健康和管理怀孕结果中起着至关重要的作用，包括 妊娠糖尿病，早产和产后抑郁症。但是，减轻昼夜节律的干预措施 尽管不可用的非药理学昼夜节律，但缺乏怀孕期间的节奏破坏 干预措施。昼夜节律制度得到了加强和对齐24小时的光线， 环境光操纵可以改变阶段并改变基于昼夜节律的幅度 在仔细的时机上并与其他行为结合在一起。 该阶段I STTR项目旨在评估昼夜节律疗法的可行性 （CST-L）在社会经济多样化的孕妇中。干预涉及明亮的光 特定时间暴露于相位前进，延迟或提高昼夜节律的幅度，昏暗的光线 其他时间，以及使用日记来跟踪昼夜节律破坏的原因。评估成功的成功 试验，我们将使用该应用程序和蓝锁眼镜收集20名孕妇的主观反馈 在四个星期内，将对用户反馈进行迭代更新。最终目标是 为iOS和Android开发移动应用程序，可提供CST-L并有助于改善母性情绪 和健康以及婴儿睡眠训练。如果成功，这种干预可以帮助减少早产的风险 出生，产后抑郁症以及怀孕期间和其他差的结果。