Innovative, non-invasive, battery-less, disposable cardiac biosensor for hemodynamic monitoring

用于血流动力学监测的创新、非侵入、无电池、一次性心脏生物传感器

• 批准号: 10188673
• 负责人: Kaustubh Kale
• 金额: $ 22.5万
• 依托单位: AVENTUSOFT, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2022-03-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10188673
• 关键词: Accelerometer; Address; Adhesives; Adult; Aging; Algorithms; Ambulatory Monitoring; Android; Biosensor; Blood; Blood Pressure; Bradycardia; Caliber; Cardiac; Cardiovascular Diseases; Cardiovascular system; Caring; Cellular Phone; Cessation of life; Chronic; Communication; Companions; Complex; Computer software; Congestive; Congestive Heart Failure; Consultations; Coronary Artery Bypass; Data; Data Store; Development; Devices; Diagnosis; Echocardiography; Economics; Education; Elderly; Electrocardiogram; Ensure; Environment; Etiology; Event; Goals; Gold; Harvest; Health Insurance Portability and Accountability Act; Health Personnel; Healthcare; Heart; Heart Abnormalities; Heart Rate; Heart Valves; Home; Hospitalization; Hospitals; Human; Individual; Intervention; Lead; Left; Legal patent; Lung; Measurement; Measures; Medical; Medical Care Team; Medical Device Designs; Modeling; Monitor; Myocardial Infarction; Operative Surgical Procedures; Outpatients; Patient Education; Patient Monitoring; Patients; Phase; Primary Health Care; Procedures; Public Health; Pulmonary artery structure; Quality of life; Radio communications; Reader; Recovery; Reporting; Scientist; Secure; Signal Transduction; Skin; Small Business Innovation Research Grant; Sternum; Supervision; System; Tachycardia; Technology; Telephone; Testing; Time; Validation; Ventricular; Visit; Weight; Wireless Technology; Work; base; care providers; clinical practice; dashboard; design; detection method; empowered; evidence base; heart function; hemodynamics; high risk; hospital readmission; implantable device; improved; innovation; insight; light weight; mortality; multidisciplinary; new technology; non-compliance; novel; older patient; patient population; portability; pressure; prototype; pulmonary function; radio frequency; smart watch; smartphone Application; time interval; trend; vibration

7. PROJECT SUMMARY/ABSTRACT This SBIR Phase I project will design and develop an innovative, miniature, battery-less, disposable cardiac biosensor, to provide easy home assessment of heart and lung function. The biosensor will deliver comparable hemodynamic measurements to the gold standard assessments. Economic impetus has led to early discharge of complex and elderly patients with cardiovascular disease. Older adults discharged from hospitals following diagnoses of congestive heart failure exacerbation, myocardial infarction, coronary artery bypass grafting surgery or other high-risk cardiac procedures are at higher risk for re-hospitalizations and increased mortality resulting from gaps in care following hospital discharge. The assessment solutions available for patient monitoring at home, namely, blood pressure, weight, electrocardiograms, have not demonstrated reduction in readmission for any reason or death of any causes after discharge. Invasive implant devices, such as CardioMEMS, have demonstrated that hemodynamic measurements allow more effective management leading to fewer hospitalizations and lower deaths. Thus, aging adults are in need of reliable, robust, safe (non-invasive), and simple technologies that can provide hemodynamic assessment post hospitalization. There is need for meaningful interventions through a phone consultation or outpatient primary care visits that reduce re-admissions and mortality. Using this SBIRs technology, it will be possible for a patient to have access to gold standard hemodynamic measurements, through an integrated, wearable, battery-less, cardiac biosensor. The biosensor’s data can be read with a smart phone using secure near field communication, enabling patients and their health care providers to have easy access to their hemodynamic measurements via a smartphone application. Early objective measurements of hemodynamic changes will lead to early and prompt outpatient interventions. This will improve the quality of life for individuals with chronic cardiovascular conditions enabling them to remain at home longer. We have a multidisciplinary team of scientists and practice stakeholders who will work together to develop and test the conceptual model that will be applicable across diverse patient populations. The overall goal of this project it to demonstrate that new technology can meaningfully accommodate the needs of older adults and address their unique problems and challenges. For the first time there will be a biosensor that truly addresses the market need of an un-obstructive, non-invasive, accurate, absolute and actionable system for post-discharge use at home. This will facilitate close self-monitoring and outpatient monitoring of our most vulnerable patients, while maintaining close supervision by the health care teams. This battery-less, disposable biosensor technology for providing in-depth hemodynamics has additional far reaching benefits. Such a device does not exist today thus opening up numerous commercial possibilities.

7。项目摘要/摘要 这个SBIR阶段项目将设计和开发创新的，微型，无电击，一次性心脏 生物传感器，可轻松地评估心脏和肺功能。生物传感器将提供可比的 黄金标准评估的血液动力学测量。经济动力已导致早期出院 复杂且古老的患有心血管疾病的患者。从医院出院的老年人 诊断充血性心力衰竭，心肌梗塞，冠状动脉搭桥术的诊断 手术或其他高风险心脏手术的重新住院风险较高，死亡率增加 出院后护理差距导致。可用于患者的评估解决方案 在家监测，即血压，体重，心电图，尚未显示出降低 出院后任何原因的任何原因或死亡。侵入性植入设备，例如 心脏组件已经证明，血液动力学测量可实现更有效的管理领先 减少住院和降低死亡。那是衰老的成年人需要可靠，健壮，安全（无创）， 以及可以在住院后提供血液动力学评估的简单技术。需要 通过电话咨询或门诊初级保健访问来减少重新入场的有意义的干预措施 和死亡率。使用这种SBIRS技术，患者有可能获得黄金标准 血液动力学测量通过集成，可穿戴，无电池，心脏生物传感器。生物传感器的 可以使用安全的近场通信使用智能手机读取数据，从而使患者及其健康 护理提供商可以轻松地通过智能手机应用程序访问其血液动力学测量。早期的 血液动力学变化的客观测量将导致早期和促使门诊干预措施。这 将改善患有慢性心血管状况的人的生活质量，使他们能够保持 家更长。我们有一个由科学家和实践利益相关者组成的多学科团队，他们将共同努力 开发和测试将在潜水员患者人群中适用的概念模型。总体 该项目的目标是证明新技术可以有意义地满足较老的需求 成人并解决他们独特的问题和挑战。第一次将有一个真正的生物传感器 满足市场需求的需求 放电后在家中使用。这将促进对我们最大的自我监控和门诊监控 脆弱的患者，同时维持医疗团队的密切监督。这个无电池，一次性 提供深入血液动力学的生物传感器技术具有额外的远距离益处。这样的设备 今天不存在，因此开放了许多商业可能性。