Pittsburgh Liver Research Center

匹兹堡肝脏研究中心

• 批准号: 10831584
• 负责人: Satdarshan Singh Monga
• 金额: $ 13.36万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10831584
• 关键词: Area; Award; Biomedical Research; Caring; Clinical; Collaborations; Communities; Complex; Development; Disease; Education; Educational workshop; Ensure; Environment; Fostering; Functional disorder; Funding; Health; Hepatic; Hepatobiliary; Hepatocarcinogenesis; Human; Institution; Interdisciplinary Study; Interest Group; Investigation; Leadership; Liver; Liver diseases; Medical center; Mentors; Mentorship; Mission; Molecular; Patients; Physicians; Recurrence; Regenerative Medicine; Research; Research Personnel; Resources; Schedule; Science; Scientist; Services; Translations; Transplantation; Universities; University of Pittsburgh Cancer Institute; bench-to-bedside translation; career; chronic liver disease; clinical care; commercialization; environmental enrichment for laboratory animals; health care delivery; improved; injury and repair; innovation; member; novel; parent grant; programs; research and development; technology development

Abstract (from parent grant P30DK120531 entitled Pittsburgh Liver Research Center; PI: Monga, Satdarshan): The inception of the Pittsburgh Liver Research Center (PLRC) in 2016 was the result of high enthusiasm of the leadership, which came with strong institutional support and commitment in the form of resources from both the University of Pittsburgh Medical Center (UPMC) and the University of Pittsburgh (UP). PLRC truly represents a successful partnership between UPMC, a pioneer in healthcare delivery and the UP, a renowned leader in research, discovery, education, and innovation. With the centralized mission of promoting the understanding of the cellular and molecular basis of hepatobiliary injury and repair, the PLRC has brought together a very strong group of investigators and clinicians engaged in basic and translational liver research and in the delivery of clinical care to liver patients. Over the last 2 years, PLRC has brought together the membership composed of 80 investigators and clinicians (49 full members) representing multiple departments and institutions within the UP and UPMC, as one community. This was facilitated by regular networking, physician-basic scientist roundtables, seminars and workshops, to enrich the environment making it conducive to strengthening existing collaborations and initiating new partnerships. PLRC has organized itself into 3 highly functional scientific interest groups (SIGs)−Regenerative Medicine, Chronic Liver Diseases, and Liver Tumorigenesis−with overlapping membership and regularly scheduled interactions facilitating a scientifically fertile environment for dialogue through a rather novel Enrichment program. SIG roundtables allow recurring dialogue between physicians and scientists on carefully selected topics and foster collaborations and more meaningful research. To enable pioneering and impactful science in the labs of PLRC investigators, we have established 3 highly integrated biomedical research cores and a clinical component that provide state-of-the-art and innovative services to enable cutting-edge research and translation from bench to bedside. Likewise, PLRC identifies new investigators and, through Pilot and Feasibility programs, supports their research and development as independent investigators through longitudinal mentorship and offering career and professional development activities in addition to scientific support. Special awards via institutional support allow funding of team science projects that promote physician and basic scientist interactions, technology development and commercialization. All of the above services and functions that are aimed at discerning complex tribulations in hepatic health and disease via research in the area of hepatobiliary injury and repair through promoting innovative, collaborative inter-, trans and multi-disciplinary research, to make a sustainable impact on human health, are ensured by a strong leadership and organization provided under the aegis of an Administrative Core. In fact, the PLRC leadership has leveraged many existing strengths of the institute like CTSI, Innovation Institute and the Coulter program as well as formed alliances with existing institutes like the University of Pittsburgh Cancer Institute, Starzl Transplant Institute and the McGowan Institute of Regenerative Medicine to expand services and benefits provided by the PLRC to all its members and eventually better their science, translation and commercialization. Thus, eventually, through their integrated services and programs, the long-term objective of the PLRC is to promote impactful science in the area of hepatobiliary pathophysiology and improve the hepatic health and care, both locally and globally.

摘要（来自父母赠款P30DK120531题为匹兹堡肝脏研究中心； PI：Monga，Satdarshan）： 2016年，匹兹堡肝脏研究中心（PLRC）的诞生是领导力热情的结果， 这具有强烈的机构支持和承诺，以来自大学的资源形式 匹兹堡医学中心（UPMC）和匹兹堡大学（UP）。 PLRC确实代表了成功的伙伴关系 在医疗保健交付的先驱UPMC和UP领域，著名的研究，发现，教育和 创新。以促进对细胞和分子基础的理解的集中任务 PLRC肝损伤和维修，汇集了一群非常强大的研究人员和临床医生 从事基本和翻译的肝脏研究以及向肝脏患者提供临床护理。在过去的两年中， PLRC汇集了由80位调查人员和临床医生（49位完整成员）组成的会员资格 UP和UPMC中的多个部门和机构是一个社区。这是由常规的 网络，物理基础科学家圆桌会议，半小便和讲习班，以丰富环境 导电以加强现有的合作并启动新的合作伙伴关系。 PLRC已组织成3 高功能性科学利益群体（SIGS） - 再生医学，慢性肝病和肝脏 肿瘤发生与重叠的会员资格和定期安排的互动促进了科学肥沃的 通过一个相当新颖的丰富计划进行对话的环境。 SIG圆桌会议允许重复对话 医师和科学家在精心挑选的主题和培养合作以及更有意义的研究之间进行研究。 为了在PLRC研究者的实验室中启用开拓性和有影响力的科学，我们建立了3个高度整合的 生物医学研究核心和提供最先进和创新服务的临床组成部分 从长凳到床边的尖端研究和翻译。同样，PLRC确定了新的调查人员，并通过 飞行员和可行性计划，通过 除科​​学支持外，纵向心态以及提供职业和专业发展活动。 通过机构支持的特别奖项允许资助团队科学项目，以促进身体和基础科学家 互动，技术开发和商业化。以上所有针对的服务和功能 通过在肝损伤和修复领域的研究中辨别肝健康和疾病中的复杂磨难 通过促进创新，协作，跨学科和多学科研究，以产生可持续的影响 关于人类健康的，由行政的宙斯盾的强大领导和组织确保了 核。实际上，PLRC领导层利用了该研究所的许多现有优势，例如CTSI，创新研究所 以及库尔特计划以及与匹兹堡癌大学等现有机构的联盟 研究所，Starzl移植研究所和McGowan再生医学研究所，以扩大服务和 PLRC为所有成员提供的好处，并最终改善其科学，翻译和商业化。 最终，通过其集成的服务和计划，PLRC的长期目标是促进 在肝脏病理生理学领域有影响力的科学，并在本地和 全球。